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Protein Page:
SLCO1B3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLCO1B3 Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B3 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: integral to plasma membrane; basolateral plasma membrane; plasma membrane
Molecular Function: organic anion transmembrane transporter activity
Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport
Reference #:  Q9NPD5 (UniProtKB)
Alt. Names/Synonyms: Liver-specific organic anion transporter 2; liver-specific organic anion transporter 3TM13; LST-2; LST-3TM13; LST2; LST3; OATP-8; OATP1B3; OATP8; Organic anion transporter 8; organic anion transporter LST-3c; Organic anion-transporting polypeptide 8; SLC21A8; SLCO1B3; SO1B3; solute carrier family 21 (organic anion transporter), member 8; Solute carrier family 21 member 8; Solute carrier organic anion transporter family member 1B3; solute carrier organic anion transporter family, member 1B3
Gene Symbols: SLCO1B3
Molecular weight: 77,403 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below

SLCO1B3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K9 DQHQHLNKTAESASS
0 1 Y38-p LAALSFSyIAKALGG
0 1 K49 ALGGIIMKISITQIE
0 1 K291 NKPQKERKIsLsLHV
0 8 S293-p PQKERKIsLsLHVLK
0 7 S295-p KERKIsLsLHVLKTN
0 1 K300 sLsLHVLKTNDDRNQ
0 1 R305 VLKTNDDRNQTANLT
0 1 K316 ANLTNQGKNVTKNVT
0 1 Y537-p CTRKFFIyVAIQVIN
0 1 T559-p GTTFILLtVKIVQPE
0 1 K568 KIVQPELKALAMGFQ
0 1 T598-p FGALIDKtCMKWstN
0 1 K601 LIDKtCMKWstNsCG
0 1 S603-p DKtCMKWstNsCGAQ
0 1 T604-p KtCMKWstNsCGAQG
0 1 S606-p CMKWstNsCGAQGAC
0 2 - gap
0 1 K657 KFQGKDTKASDNERK
0 1 K664 KASDNERKVMDEANL
0 25 M666 SDNERKVMDEANLEF
0 2 D687 FVPSAGTDSKTCNLD
  SLCO1B3 iso3  
K9 DQHQHLNKTAESASS
Y38 LAALSFSYIAKALGG
K49 ALGGIIMKISITQIE
K291 NKPQKERKISLSLHV
S293 PQKERKISLSLHVLK
S295 KERKISLSLHVLKTN
K300 SLSLHVLKTNDDRNQ
R305 VLKTNDDRNQTANLT
K316 ANLTNQGKNVTKNVT
Y537 CTRKFFIYVAIQVIN
T559 GTTFILLTVKIVQPE
K568 KIVQPELKALAMGFQ
T598 FGALIDKTCMKWSTN
K601 LIDKTCMKWSTNSCG
S603 DKTCMKWSTNSCGAQ
T604 KTCMKWSTNSCGAQG
S606 CMKWSTNSCGAQGAC
S667-p CMKWSTNsCGARGAC
- gap
- gap
- gap
- gap
  mouse

 
K9-ub DQTQHPSkAAQPLRS
Y36 LAALSFSYICKALGG
K47-ub ALGGVIMkSSITQIE
K286-ub KRSQKERkNsAsLHV
S288-p SQKERkNsAsLHVLk
S290-p KERkNsAsLHVLkTD
K295-ub sAsLHVLkTDEDkNP
K300-ub VLkTDEDkNPVTNPT
K311-ub TNPTTQEkQAPANLT
Y533 CKTKYYFYITFQVII
L555 STSLMLILIRSVQPE
K564-ub RSVQPELkSLGMGFH
T594 YGALIDRTCMkWSVT
K597-ub LIDRTCMkWSVTSCG
S599 DRTCMkWSVTSCGAR
V600 RTCMkWSVTSCGARG
S602 CMkWSVTSCGARGAC
- gap
K653-ub KMKRNDNkILENGRk
K660-ub kILENGRkFtDEGNP
T662-p LENGRkFtDEGNPEP
K683-ub SCVPSDEkNSETPL_
  rat

 
K9 DHTQQSRKAAEAQPS
Y38 LAALSFSYICKALGG
K49 ALGGVVMKSSITQIE
K288 KRSQEERKNsVsLHA
S290-p SQEERKNsVsLHAPK
S292-p EERKNsVsLHAPKTD
K297 sVsLHAPKTDEEKKH
K302 APKTDEEKKHMTNLT
E313 TNLTKQEEQDPSNMT
Y531 CKTNYYFYIILQVTV
L553 SPSLILILMKSVQPE
K562 KSVQPELKSLAMGFH
T592 YGAFIDRTCIKWSVT
K595 FIDRTCIKWSVTSCG
S597 DRTCIKWSVTSCGKR
V598 RTCIKWSVTSCGKRG
S600 CIKWSVTSCGKRGAC
- gap
K651 KYKRNDNKTLENGRQ
Q658 KTLENGRQFtDEGNP
T660-p LENGRQFtDEGNPDS
Q681 YCVPYDEQSNETPL_
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