a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 18.104.22.168; Protein kinase, CMGC; EC 22.214.171.124; Kinase, protein; CMGC group; GSK family; GSK subfamily
Molecular Function: p53 binding; nucleotide binding; beta-catenin binding; transcription factor binding; protein kinase binding; protein kinase activity; transferase activity; integrin binding; NF-kappaB binding; protein serine/threonine kinase activity; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding
Biological Process: circadian rhythm; glycogen metabolic process; fat cell differentiation; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of apoptosis; multicellular organismal development; positive regulation of axon extension; rhythmic process; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; negative regulation of protein binding; ER overload response; nervous system development; regulation of microtubule-based process; negative regulation of nitric-oxide synthase activity; myotube differentiation; negative regulation of dendrite morphogenesis; regulation of axon extension; negative regulation of NFAT protein import into nucleus; organ morphogenesis; negative regulation of neuron maturation; carbohydrate metabolic process; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of neuronal synaptic plasticity; negative regulation of apoptosis; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; regulation of dendrite morphogenesis; establishment and/or maintenance of cell polarity; regulation of axonogenesis; positive regulation of protein export from nucleus; positive regulation of neuron apoptosis; protein export from nucleus; cell differentiation; positive regulation of cell-matrix adhesion; myoblast fusion; cell migration; Wnt receptor signaling pathway; hippocampus development; cytoskeleton organization and biogenesis; positive regulation of peptidyl-serine phosphorylation; negative regulation of signal transduction; cell proliferation; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; axonogenesis; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; epithelial to mesenchymal transition; phosphorylation; negative regulation of protein complex assembly; positive regulation of GTPase activity
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.