a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein kinase, CMGC; Kinase, protein; EC 18.104.22.168; Protein kinase, Ser/Thr (non-receptor); CMGC group; GSK family; GSK subfamily
Cellular Component: centrosome; protein complex; dendritic spine; cytosol; beta-catenin destruction complex; ribonucleoprotein complex; lipid raft; growth cone; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus
Molecular Function: p53 binding; beta-catenin binding; nucleotide binding; protein kinase binding; transcription factor binding; protein kinase activity; integrin binding; transferase activity; ionotropic glutamate receptor binding; protein serine/threonine kinase activity; NF-kappaB binding; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; tau protein binding; ATP binding
Biological Process: fat cell differentiation; glycogen metabolic process; circadian rhythm; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of protein binding; positive regulation of apoptosis; multicellular organismal development; establishment and/or maintenance of cell polarity; rhythmic process; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; negative regulation of protein binding; positive regulation of cell-matrix adhesion; cell differentiation; myoblast fusion; ER overload response; nervous system development; regulation of microtubule-based process; cell migration; Wnt receptor signaling pathway; hippocampus development; myotube differentiation; negative regulation of dendrite morphogenesis; cytoskeleton organization and biogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of signal transduction; cell proliferation; negative regulation of neuron maturation; peptidyl-serine phosphorylation; organ morphogenesis; positive regulation of protein complex assembly; axonogenesis; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; carbohydrate metabolic process; epithelial to mesenchymal transition; positive regulation of Rac GTPase activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; phosphorylation; regulation of neuronal synaptic plasticity; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.