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GSK3B (mouse)

Overview GSK3B a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.26; EC 2.7.11.1; Protein kinase, CMGC; CMGC group; GSK family; GSK subfamily Cellular Component: centrosome; protein complex; dendritic spine; ribonucleoprotein complex; cytosol; beta-catenin destruction complex; lipid raft; growth cone; membrane; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus Molecular Function: p53 binding; beta-catenin binding; nucleotide binding; protein kinase binding; protein kinase activity; integrin binding; transferase activity; NF-kappaB binding; ionotropic glutamate receptor binding; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding Biological Process: fat cell differentiation; glycogen metabolic process; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of protein binding; multicellular organismal development; establishment and/or maintenance of cell polarity; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; response to stress; protein export from nucleus; positive regulation of cell-matrix adhesion; negative regulation of protein binding; cell differentiation; myoblast fusion; ER overload response; nervous system development; regulation of microtubule-based process; cell migration; Wnt receptor signaling pathway; hippocampus development; myotube differentiation; negative regulation of dendrite morphogenesis; cytoskeleton organization and biogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of signal transduction; cell proliferation; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; axonogenesis; establishment of cell polarity; induction of apoptosis; carbohydrate metabolic process; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Rac GTPase activity; negative regulation of transcription, DNA-dependent; phosphorylation; negative regulation of protein complex assembly; regulation of neuronal synaptic plasticity; negative regulation of apoptosis Reference #:  Q9WV60 (UniProtKB) Alt. Names/Synonyms: 7330414F15Rik; 8430431H08Rik; C86142; glycogen synthase kinase 3 beta; Glycogen synthase kinase-3 beta; GSK-3; GSK-3 beta; GSK-3beta; GSK3; Gsk3b; OTTMUSP00000017445 Gene Symbols: Gsk3b Molecular weight: 46,710 Da Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Regulation of Microtubule Dynamics  |  Translation: eIF2  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GSK3B 1GNG - A/B=27-393 (human) 1H8F - A/B=35-386 (human) 1I09 - A/B=1-420 (human) 1J1B - A/B=1-420 (human) 1J1C - A/B=1-420 (human) 1O9U - A=35-384 (human) 1PYX - A/B=1-420 (human) 1Q3D - A/B=2-420 (human) 1Q3W - A/B=2-420 (human) 1Q41 - A/B=2-420 (human) 1Q4L - A/B=2-420 (human) 1Q5K - A/B=7-420 (human) 1R0E - A/B=35-420 (human) 1UV5 - A=35-384 (human) 2JDO - C=3-12 (human) 2JDR - C=3-12 (human) 2JLD - A/B=1-420 (human) 2O5K - A=29-393 (human) 2OW3 - A/B=35-386 (human) 2UW9 - C=3-12 (human) 2X39 - C=3-12 (human) 2XH5 - C=3-12 (human) 3CQU - C=3-12 (human) 3CQW - C=3-12 (human) 3DU8 - A/B=1-420 (human) 3E87 - D/C=3-12 (human) 3E88 - D/C=3-12 (human) 3E8D - D/C=3-12 (human) 3F7Z - A/B=35-383 (human) 3F88 - A/B=35-383 (human) 3GB2 - A=34-383 (human) 3I4B - A/B=7-420 (human) 3L1S - A/B=7-420 (human) 3M1S - A/B=1-420 (human) 3PUP - A/B=1-420 (human) 3Q3B - A/B=2-420 (human) 3SAY - A/B=1-420 (human) 3SD0 - A/B=35-384 (human) 3ZDI - A=35-384 (human) 3ZRK - A/B=23-393 (human) 3ZRL - A/B=23-393 (human) 3ZRM - A/B=23-393 (human) 4ACC - A/B=1-420 (human) 4ACD - A/B=1-420 (human) 4ACG - A/B=1-420 (human) 4ACH - A/B=1-420 (human) 4AFJ - A/B=27-393 (human) 4B7T - A=35-384 (human) 4DIT - A=27-393 (human) 4EKK - D/C=3-12 (human) 4IQ6 - A/B=1-420 (human) 4J1R - A/D/C/B=1-420 (human) 4J71 - A/B=1-420 (human) Substrate Sequence Logo

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	Sites Implicated In
cell growth, altered: S9‑p cytoskeletal reorganization: S9‑p enzymatic activity, inhibited: S9‑p intracellular localization: S9‑p phosphorylation: S9‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	19		T7-p	_MSGRPRttsFAEsC
0	19		T8-p	MSGRPRttsFAEsCK
336	221		S9-p	SGRPRttsFAEsCKP
0	4		S13-p	RttsFAEsCKPVQQP
3	9		S21-p	CKPVQQPsAFGsMKV
0	70		S25-p	QQPsAFGsMKVSRDK
0	1		S35	VSRDKDGSKVTTVVA
1	1		T43	KVTTVVATPGQGPDR
0	9		Y71	NGSFGVVYQAKLCDS
1	0		-	under review
0	7		K205-u	LCDFGSAkQLVRGEP
0	1207		S215-p	VRGEPNVsyICsRYY
57	4239		Y216-p	RGEPNVsyICsRYYR
1	1108		S219-p	PNVsyICsRYYRAPE
0	111		Y221	VsyICsRYYRAPELI
0	7		Y222	syICsRYYRAPELIF
0	3		K292-u	NPNYTEFkFPQIKAH
1	0		K292	NPNYTEFKFPQIKAH
1	6		S389-p	ARIQAAAsPPANAtA
0	19		P390	RIQAAAsPPANAtAA
0	2		A392	QAAAsPPANAtAASD
0	1		T395-p	AsPPANAtAASDTNA
0	1		A402	tAASDTNAGDRGQTN
0	1		S417	NAASASASNST____

	human ► Hide Isoforms
T7-p	_MSGRPRttsFAEsC
T8-p	MSGRPRttsFAEsCK
S9-p	SGRPRttsFAEsCKP
S13-p	RttsFAEsCKPVQQP
S21-p	CKPVQQPsAFGsMKV
S25-p	QQPsAFGsMKVSRDK
S35-p	VSRDKDGsKVTTVVA
T43-p	KVTTVVAtPGQGPDR
Y71-p	NGSFGVVyQAKLCDS
-	under review
K205-u	LCDFGSAkQLVRGEP
S215-p	VRGEPNVsyICsRyy
Y216-p	RGEPNVsyICsRyyR
S219-p	PNVsyICsRyyRAPE
Y221-p	VsyICsRyyRAPELI
Y222-p	syICsRyyRAPELIF
K292-u	NPNYTEFkFPQIKAH
K292-s	NPNYTEFkFPQIKAH
S389-p	ARIQAAAstPtNATA
T390-p	RIQAAAstPtNATAA
T392-p	QAAAstPtNATAASD
T395	AstPtNATAASDANt
T402-p	TAASDANtGDRGQTN
S417-p	NAASASAsNST____

	GSK3B iso2
T7	_MSGRPRTTsFAESC
T8	MSGRPRTTsFAESCK
S9-p	SGRPRTTsFAESCKP
S13	RTTsFAESCKPVQQP
S21	CKPVQQPSAFGSMKV
S25	QQPSAFGSMKVSRDK
S35	VSRDKDGSKVTTVVA
T43	KVTTVVATPGQGPDR
Y71	NGSFGVVYQAKLCDS
-	under review
K205	LCDFGSAKQLVRGEP
S215	VRGEPNVSyICSRYY
Y216-p	RGEPNVSyICSRYYR
S219	PNVSyICSRYYRAPE
Y221	VSyICSRYYRAPELI
Y222	SyICSRYYRAPELIF
K292	NPNYTEFKFPQIKAH
K292	NPNYTEFKFPQIKAH
S402	ARIQAAASTPTNATA
T403	RIQAAASTPTNATAA
T405	QAAASTPTNATAASD
T408	ASTPTNATAASDANT
T415	TAASDANTGDRGQTN
S430	NAASASASNST____

	rat
T7	_MSGRPRTTsFAESC
T8	MSGRPRTTsFAESCK
S9-p	SGRPRTTsFAESCKP
S13	RTTsFAESCKPVQQP
S21	CKPVQQPSAFGSMKV
S25	QQPSAFGSMKVSRDK
S35	VSRDKDGSKVTTVVA
T43	KVTTVVATPGQGPDR
Y71-p	NGSFGVVyQAKLCDS
K205-a	LCDFGSAkQLVRGEP
K205	LCDFGSAKQLVRGEP
S215-p	VRGEPNVsyICsRyY
Y216-p	RGEPNVsyICsRyYR
S219-p	PNVsyICsRyYRAPE
Y221-p	VsyICsRyYRAPELI
Y222	syICsRyYRAPELIF
K292	NPNYTEFKFPQIKAH
K292	NPNYTEFKFPQIKAH
S389	ARIQAAASPPANATA
P390	RIQAAASPPANATAA
A392	QAAASPPANATAASD
T395	ASPPANATAASDTNA
A402	TAASDTNAGDRGQTN
S417	NAASASASNST____

	rabbit
-	gap
T2	______XTSFAESXK
S3	_____XTSFAESXKP
S7	_XTSFAESXKPVQQP
S15	XKPVQQPSAFGS___
S19	QQPSAFGS_______
-	gap
-	gap
-	gap
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

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