Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PCK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PCK1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Defects in PCK1 are the cause of cytosolic phosphoenolpyruvate carboxykinase deficiency (C-PEPCKD). A metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autoposy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.1.1.32; Lyase; Carbohydrate Metabolism - citrate (TCA) cycle; Kinase, other; Carbohydrate Metabolism - pyruvate
Cellular Component: cytoplasm; cytosol
Molecular Function: GDP binding; GTP binding; carboxylic acid binding; manganese ion binding; phosphoenolpyruvate carboxykinase (GTP) activity; magnesium ion binding
Biological Process: oxaloacetate metabolic process; carbohydrate metabolic process; glucose metabolic process; response to activity; glycerol biosynthetic process from pyruvate; drug metabolic process; glucose homeostasis; internal protein amino acid acetylation; response to insulin stimulus; gluconeogenesis
Reference #:  P35558 (UniProtKB)
Alt. Names/Synonyms: MGC22652; PCK1; PCKGC; PEP carboxykinase; PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase, cytosolic; Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase
Gene Symbols: PCK1
Molecular weight: 69,195 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PCK1

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S19-p SAKVVQGsLDSLPQA
0 1 K70-ac EGILRRLkkYDNCWL
0 1 K71-ac GILRRLkkYDNCWLA
0 1 K71 GILRRLkKYDNCWLA
0 1 K91 DVARIESKTVIVTQE
0 1 K107 RDTVPIPKTGLSQLG
0 5 S118 SQLGRWMSEEDFEKA
0 1 K124 MSEEDFEKAFNARFP
0 2 K124 MSEEDFEKAFNARFP
0 1 K135 ARFPGCMKGRTMYVI
0 1 T178-p RIMTRMGtPVLEAVG
0 1 Q203 VGCPLPLQKPLVNNW
0 1 K204 GCPLPLQKPLVNNWP
0 2 K243-ub GGNSLLGkKCFALRM
0 1 K278 TNPEGEKKYLAAAFP
0 1 S286 YLAAAFPSACGKTNL
0 1 K290 AFPSACGKTNLAMMN
0 1 K316 GDDIAWMKFDAQGHL
0 1 K342 VAPGTSVKTNPNAIK
0 1 K349 KTNPNAIKTIQKNTI
0 1 K389 TITSWKNKEWSSEDG
0 2 K471 ATAAAEHKGKIIMHD
0 1 K524 FRKDKEGKFLWPGFG
0 1 K551 IDGKASTKLTPIGyI
0 1 Y557-p TKLTPIGyIPKEDAL
0 1 K560 TPIGyIPKEDALNLK
0 1 K567 KEDALNLKGLGHINM
0 1 K587 ISKEFWEKEVEDIEk
0 1 K594-ac KEVEDIEkYLEDQVN
  mouse

 
S19-p SAKVIQGsLDSLPQA
K70 EGVIRKLKkYDNCWL
K71 GVIRKLKKYDNCWLA
K71-ub GVIRKLKkYDNCWLA
K91-ub DVARIESkTVIITQE
K107-ub RDTVPIPkTGLSQLG
S118-p SQLGRWMsEEDFEkA
K124-ac MsEEDFEkAFNARFP
K124-ub MsEEDFEkAFNARFP
K135-ub ARFPGCMkGRTMYVI
I178 RIMTRMGISVLEALG
K203-ub VGCPLPLkkPLVNNW
K204-ub GCPLPLkkPLVNNWA
K243-ub GGNSLLGkKCFALRI
K278-ub TNPEGKKkYLAAAFP
S286-p YLAAAFPsACGkTNL
K290-ub AFPsACGkTNLAMMN
K316-ub GDDIAWMkFDAQGNL
K342-ub VAPGTSVkTNPNAIk
K349-ub kTNPNAIkTIQKNTI
K389-ub TITSWKNkEWRPQDA
K471-ub ATAAAEHkGKIIMHD
K524-ub FRKDKDGkFLWPGFG
K551-ub IEGEDSAkLTPIGYI
Y557 AkLTPIGYIPkENAL
K560-ub TPIGYIPkENALNLk
K567-ub kENALNLkGLGGVNV
K587-ub ISKEFWEkEVEEIDR
R594 kEVEEIDRYLEDQVN
  rat

 
S19-p SAKVIQGsLDSLPQE
K70 EGVIRKLKKYDNCWL
K71 GVIRKLKKYDNCWLA
K71 GVIRKLKKYDNCWLA
K91 DVARIESKTVIITQE
K107 RDTVPIPKSGQSQLG
S118-p SQLGRWMsEEDFEKA
K124 MsEEDFEKAFNARFP
K124 MsEEDFEKAFNARFP
K135 ARFPGCMKGRTMYVI
T178 RIMTRMGTSVLEALG
K203 VGCPLPLKKPLVNNW
K204 GCPLPLKKPLVNNWA
K243 GGNSLLGKKCFALRI
K278 TNPEGKKKYLAAAFP
S286 YLAAAFPSACGKTNL
K290 AFPSACGKTNLAMMN
K316 GDDIAWMKFDAQGNL
K342 VAPGTSVKTNPNAIK
K349 KTNPNAIKTIQKNTI
K389 TITSWKNKEWRPQDE
K471 ATAAAEHKGKVIMHD
K524 FRKDKNGKFLWPGFG
K551 IEGEDSAKLTPIGYV
Y557 AKLTPIGYVPKEDAL
K560 TPIGYVPKEDALNLK
K567 KEDALNLKGLGDVNV
K587 ISKEFWEKEVEEIDK
K594 KEVEEIDKYLEDQVN
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.