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Protein Page:
SLC4A4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SLC4A4 Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA); also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy. Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17). Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; inorganic anion exchanger activity; sodium:bicarbonate symporter activity
Biological Process: bicarbonate transport; transport; ion transport; transmembrane transport
Reference #:  Q9Y6R1 (UniProtKB)
Alt. Names/Synonyms: DKFZp781H1314; Electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC1; KNBC; kNBC1; Na(+)/HCO3(-) cotransporter; NBC; NBC1; NBC2; NBCE1; pNBC; S4A4; SLC4A4; SLC4A5; Sodium bicarbonate cotransporter; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas); Solute carrier family 4 member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
Gene Symbols: SLC4A4
Molecular weight: 121,461 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC4A4

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
activity, induced: T49‑p, S1026‑p
intracellular localization: S65‑p
molecular association, regulation: S1026‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 39 S12-p AVLDRGAsFLKHVCD
0 25 Y30-p VEGHHTIyIGVHVPK
2 0 T49-p RRRHKRKtGHKEKKE
0 3 S61-p KKEKERIsENysDKs
0 4 Y64-p KERIsENysDKsDIE
1 10 S65-p ERIsENysDKsDIEN
0 1 K67 IsENysDKsDIENAD
0 10 S68-p sENysDKsDIENADE
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S86 SILKPLISPAAERIR
0 1 K137 RWIKFEEKVEQGGER
0 1 S146 EQGGERWSKPHVATL
0 2 K167-a ELRTCMEkGSIMLDR
0 1 K167 ELRTCMEKGSIMLDR
0 1 K197 QIETGLLKPELKDKV
0 1 K203 LKPELKDKVTYTLLR
0 2 S223-p TKKSNLRsLADIGKT
0 1 K229 RsLADIGKTVssASR
0 9 S232-p ADIGKTVssASRMFT
0 6 S233-p DIGKTVssASRMFTN
0 3 S235 GKTVssASRMFTNPD
0 34 S245-p FTNPDNGsPAMtHRN
0 6 T249-p DNGsPAMtHRNLtss
0 178 T254-p AMtHRNLtsssLNDI
0 35 S255-p MtHRNLtsssLNDIS
0 27 S256-p tHRNLtsssLNDISD
0 123 S257-p HRNLtsssLNDISDK
0 2 S262 sssLNDISDKPEKDQ
0 1 K267 DISDKPEKDQLKNKF
0 1 K331 LFILLGPKGKAKSYH
0 1 K359 VFHDIAYKAKDRHDL
0 1 K395 AIRIEPPKSLPSSDK
0 1 K404 LPSSDKRKNMYSGGE
0 1 K448 RFCGGLIKDIKRKAP
0 1 K934 KLLLMPLKHQPDFIY
2 6 S1026-p KKKKKKGsLDsDNDD
0 16 S1029-p KKKGsLDsDNDDsDC
0 17 S1034-p LDsDNDDsDCPySEK
0 12 Y1038-p NDDsDCPySEKVPSI
0 2 S1044 PySEKVPSIKIPMDI
0 1 K1046 SEKVPSIKIPMDIME
0 1 K1062 QPFLSDSKPsDRERs
0 2 S1064-p FLSDSKPsDRERsPt
0 25 S1069-p KPsDRERsPtFLERH
0 7 P1070 PsDRERsPtFLERHt
0 29 T1071-p sDRERsPtFLERHts
0 3 T1077-p PtFLERHtsC_____
0 27 S1078-p tFLERHtsC______
0 3 - gap
0 2 - gap
0 1 - gap
  mouse

► Hide Isoforms
 
S12-p AVLDRGAsFLKHVCD
Y30-p VEGHHTIyIGVHVPK
A49 RRRHKRKAGHKEKKE
S61-p KKEKERIsENysDks
Y64-p KERIsENysDksDVE
S65-p ERIsENysDksDVEN
K67-u IsENysDksDVENAD
S68-p sENysDksDVENADE
- gap
- gap
- gap
- gap
- gap
S86-p SILKPLIsPAAERIR
K137-u RWIKFEEkVEQGGER
S146-p EQGGERWsKPHVATL
K167 ELRTCMEKGSIMLDR
K167-u ELRTCMEkGSIMLDR
K197-u QIETGLLkPDLKDkV
K203-u LkPDLKDkVTYTLLR
S223-p TKKSNLRsLADIGkT
K229-u RsLADIGkTVssAsR
S232-p ADIGkTVssAsRMFS
S233-p DIGkTVssAsRMFSN
S235-p GkTVssAsRMFSNPD
S245-p FSNPDNGsPAMtHRN
T249-p DNGsPAMtHRNLtss
T254-p AMtHRNLtsssLNDI
S255-p MtHRNLtsssLNDIs
S256-p tHRNLtsssLNDIsD
S257-p HRNLtsssLNDIsDK
S262-p sssLNDIsDKPEkDQ
K267-u DIsDKPEkDQLKNKF
K331-u LFILLGPkGKAKSYH
K359-u VFHDIAYkAKDRHDL
K395-u TIRIEPPkSLPSSDK
K404-u LPSSDKRkNMYSGGE
K448-u RFCGGLIkDIKRKAP
K934-u KLLLMPLkHQPDFIY
S1026-p KKKKKKGsLDsDNDD
S1029-p KKKGsLDsDNDDsDC
S1034-p LDsDNDDsDCPySEK
Y1038-p NDDsDCPySEKVPsI
S1044-p PySEKVPsIkIPMDI
K1046-u SEKVPsIkIPMDIME
K1062-u QPFLSDNkPLDRERs
L1064 FLSDNkPLDRERsst
S1069-p kPLDRERsstFLERH
S1070-p PLDRERsstFLERHt
T1071-p LDRERsstFLERHts
T1077-p stFLERHtsC_____
S1078-p tFLERHtsC______
- gap
- gap
- gap
  SLC4A4 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K9-u STENVEGkPNNLGER
S21-p GERGRARsstFLRVF
S22-p ERGRARsstFLRVFQ
T23-p RGRARsstFLRVFQP
S39-p FNHSIFTsAVSPAAE
S42 SIFTsAVSPAAERIR
K93 RWIKFEEKVEQGGER
S102 EQGGERWSKPHVATL
K123 ELRTCMEKGSIMLDR
K123 ELRTCMEKGSIMLDR
K153 QIETGLLKPDLKDKV
K159 LKPDLKDKVTYTLLR
S179 TKKSNLRSLADIGKT
K185 RSLADIGKTVSSASR
S188 ADIGKTVSSASRMFS
S189 DIGKTVSSASRMFSN
S191 GKTVSSASRMFSNPD
S201 FSNPDNGSPAMTHRN
T205 DNGSPAMTHRNLTSS
T210 AMTHRNLTSSSLNDI
S211 MTHRNLTSSSLNDIS
S212 THRNLTSSSLNDISD
S213 HRNLTSSSLNDISDK
S218 SSSLNDISDKPEKDQ
K223 DISDKPEKDQLKNKF
K287 LFILLGPKGKAKSYH
K315 VFHDIAYKAKDRHDL
K351 TIRIEPPKSLPSSDK
K360 LPSSDKRKNMYSGGE
K404 RFCGGLIKDIKRKAP
K890 KLLLMPLKHQPDFIY
S982 KKKKKKGSLDSDNDD
S985 KKKGSLDSDNDDSDC
S990 LDSDNDDSDCPYSEK
Y994 NDDSDCPYSEKVPSI
S1000 PYSEKVPSIKIPMDI
K1002 SEKVPSIKIPMDIME
K1018 QPFLSDNKPLDRERS
L1020 FLSDNKPLDRERSST
S1025 KPLDRERSSTFLERH
S1026 PLDRERSSTFLERHT
T1027 LDRERSSTFLERHTS
T1033 STFLERHTSC_____
S1034 TFLERHTSC______
- gap
- gap
- gap
  SLC4A4 iso4  
S12 AVLDRGASFLKHVCD
Y30 VEGHHTIYIGVHVPK
A49 RRRHKRKAGHKEKKE
S61 KKEKERISENYSDKS
Y64 KERISENYSDKSDVE
S65 ERISENYSDKSDVEN
K67 ISENYSDKSDVENAD
S68 SENYSDKSDVENADE
- gap
- gap
- gap
- gap
- gap
S86 SILKPLISPAAERIR
K137 RWIKFEEKVEQGGER
S146 EQGGERWSKPHVATL
K167 ELRTCMEKGSIMLDR
K167 ELRTCMEKGSIMLDR
K197 QIETGLLKPDLKDKV
K203 LKPDLKDKVTYTLLR
S223 TKKSNLRSLADIGKT
K229 RSLADIGKTVSSASR
S232 ADIGKTVSSASRMFS
S233 DIGKTVSSASRMFSN
S235 GKTVSSASRMFSNPD
S245 FSNPDNGSPAMTHRN
T249 DNGSPAMTHRNLTSS
T254 AMTHRNLTSSSLNDI
S255 MTHRNLTSSSLNDIS
S256 THRNLTSSSLNDISD
S257 HRNLTSSSLNDISDK
S262 SSSLNDISDKPEKDQ
K267 DISDKPEKDQLKNKF
K331 LFILLGPKGKAKSYH
K359 VFHDIAYKAKDRHDL
K395 TIRIEPPKSLPSSDK
K404 LPSSDKRKNMYSGGE
K448 RFCGGLIKDIKRKAP
K934 KLLLMPLKHQPDFIY
S1026-p KKKKKKGsLDsDNDD
S1029-p KKKGsLDsDNDDEKD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S1060-p LESLGLPsPPRtPVk
T1064-p GLPsPPRtPVkVVPQ
K1067-u sPPRtPVkVVPQIRI
  SLC4A4 iso5  
S12 AVLDRGASFLKHVCD
Y30 VEGHHTIYIGVHVPK
A49 RRRHKRKAGHKEKKE
S61 KKEKERISENYSDKS
Y64 KERISENYSDKSDVE
S65 ERISENYSDKSDVEN
K67 ISENYSDKSDVENAD
S68 SENYSDKSDVENADE
- gap
- gap
- gap
- gap
- gap
S86 SILKPLISPAAERIR
K137 RWIKFEEKVEQGGER
S146 EQGGERWSKPHVATL
K167 ELRTCMEKGSIMLDR
K167 ELRTCMEKGSIMLDR
K197 QIETGLLKPDLKDKV
K203 LKPDLKDKVTYTLLR
S223 TKKSNLRSLADIGKT
K229 RSLADIGKTVsSAss
S232-p ADIGKTVsSAssPAM
S233 DIGKTVsSAssPAMT
S235-p GKTVsSAssPAMTHR
S236-p KTVsSAssPAMTHRN
T240 SAssPAMTHRNLTSS
T245 AMTHRNLTSSSLNDI
S246 MTHRNLTSSSLNDIS
S247 THRNLTSSSLNDISD
S248 HRNLTSSSLNDISDK
S253 SSSLNDISDKPEKDQ
K258 DISDKPEKDQLKNKF
K322 LFILLGPKGKAKSYH
K350 VFHDIAYKAKDRHDL
K386 TIRIEPPKSLPSSDK
K395 LPSSDKRKNMYSGGE
K439 RFCGGLIKDIKRKAP
K925 KLLLMPLKHQPDFIY
S1017 KKKKKKGSLDSDNDD
S1020 KKKGSLDSDNDDSDC
S1025 LDSDNDDSDCPYSEK
Y1029 NDDSDCPYSEKVPSI
S1035 PYSEKVPSIKIPMDI
K1037 SEKVPSIKIPMDIME
K1053 QPFLSDNKPLDRERS
L1055 FLSDNKPLDRERSST
S1060 KPLDRERSSTFLERH
S1061 PLDRERSSTFLERHT
T1062 LDRERSSTFLERHTS
T1068 STFLERHTSC_____
S1069 TFLERHTSC______
- gap
- gap
- gap
  rat

► Hide Isoforms
 
S12 AVLDRGASFLKHVCD
Y30 VEGHHTIYIGVHVPK
A49 RRRHKRKAGHKEKKE
S61 KKEKERISENYsDKs
Y64 KERISENYsDKsDVE
S65-p ERISENYsDKsDVEN
K67 ISENYsDKsDVENAD
S68-p SENYsDKsDVENADE
- gap
- gap
- gap
- gap
- gap
S86 SILKPLISPAAERIR
K137 RWIKFEEKVEQGGER
S146 EQGGERWSKPHVATL
K167 ELRTCMEKGSIMLDR
K167 ELRTCMEKGSIMLDR
K197 QIETGLLKPDLKDKV
K203 LKPDLKDKVTYTLLR
S223 TKKSNLRSLADIGKT
K229 RSLADIGKTVSSASR
S232 ADIGKTVSSASRMFS
S233 DIGKTVSSASRMFSN
S235 GKTVSSASRMFSNPD
S245 FSNPDNGSPAMTHRN
T249 DNGSPAMTHRNLTSS
T254 AMTHRNLTSSSLNDI
S255 MTHRNLTSSSLNDIS
S256 THRNLTSSSLNDISD
S257 HRNLTSSSLNDISDK
S262 SSSLNDISDKPEKDQ
K267 DISDKPEKDQLKNKF
K331 LFILLGPKGKAKSYH
K359 VFHDIAYKAKDRHDL
K395 AIRIEPPKSLPSSDK
K404 LPSSDKRKNMYSGGE
K448 RFCGGLIKDIKRKAP
K934 KLLLMPLKHQPDFIY
S1026 KKKKKKGSLDsDNDD
S1029-p KKKGSLDsDNDDsDC
S1034-p LDsDNDDsDCPYSEK
Y1038 NDDsDCPYSEKVPSI
S1044 PYSEKVPSIKIPMDI
K1046 SEKVPSIKIPMDITE
K1062 QPFLSDNKPLDRERS
L1064 FLSDNKPLDRERSST
S1069 KPLDRERSSTFLERH
S1070 PLDRERSSTFLERHT
T1071 LDRERSSTFLERHTS
T1077 STFLERHTSC_____
S1078 TFLERHTSC______
- gap
- gap
- gap
  SLC4A4 iso2  
S2 ______MSTENVEGK
- under review  
- under review  
- under review  
- under review  
S22 ERGRARSSTFLRVFQ
- under review  
- under review  
- under review  
- under review  
- under review  
- under review  
- under review  
S42 SIFTSAVSPAAERIR
K93 RWIKFEEKVEQGGER
S102 EQGGERWSKPHVATL
K123 ELRTCMEKGSIMLDR
K123 ELRTCMEKGSIMLDR
K153 QIETGLLKPDLKDKV
K159 LKPDLKDKVTYTLLR
S179 TKKSNLRSLADIGKT
K185 RSLADIGKTVSSASR
S188 ADIGKTVSSASRMFS
S189 DIGKTVSSASRMFSN
S191 GKTVSSASRMFSNPD
S201 FSNPDNGSPAMTHRN
T205 DNGSPAMTHRNLTSS
T210 AMTHRNLTSSSLNDI
S211 MTHRNLTSSSLNDIS
S212 THRNLTSSSLNDISD
S213 HRNLTSSSLNDISDK
S218 SSSLNDISDKPEKDQ
K223 DISDKPEKDQLKNKF
K287 LFILLGPKGKAKSYH
K315 VFHDIAYKAKDRHDL
K351 AIRIEPPKSLPSSDK
K360 LPSSDKRKNMYSGGE
K404 RFCGGLIKDIKRKAP
K890 KLLLMPLKHQPDFIY
S982 KKKKKKGSLDSDNDD
S985 KKKGSLDSDNDDSDC
S990 LDSDNDDSDCPYSEK
Y994 NDDSDCPYSEKVPSI
S1000 PYSEKVPSIKIPMDI
K1002 SEKVPSIKIPMDITE
K1018 QPFLSDNKPLDRERS
L1020 FLSDNKPLDRERSST
S1025 KPLDRERSSTFLERH
S1026 PLDRERSSTFLERHT
T1027 LDRERSSTFLERHTS
T1033 STFLERHTSC_____
S1034 TFLERHTSC______
- under review  
- under review  
- under review  
  SLC4A4 iso3  
S12 AVLDRGASFLKHVCD
Y30 VEGHHTIYIGVHVPK
A49 RRRHKRKAGHKEKKE
S61 KKEKERISENYSDKS
Y64 KERISENYSDKSDVE
S65 ERISENYSDKSDVEN
K67 ISENYSDKSDVENAD
S68 SENYSDKSDVENADE
- gap
- gap
- gap
- gap
- gap
S86 SILKPLISPAAERIR
K137 RWIKFEEKVEQGGER
S146 EQGGERWSKPHVATL
K167 ELRTCMEKGSIMLDR
K167 ELRTCMEKGSIMLDR
K197 QIETGLLKPDLKDKV
K203 LKPDLKDKVTYTLLR
S223 TKKSNLRSLADIGKT
K229 RSLADIGKTVSSASR
S232 ADIGKTVSSASRMFS
S233 DIGKTVSSASRMFSN
S235 GKTVSSASRMFSNPD
S245 FSNPDNGSPAMTHRN
T249 DNGSPAMTHRNLTSS
T254 AMTHRNLTSSSLNDI
S255 MTHRNLTSSSLNDIS
S256 THRNLTSSSLNDISD
S257 HRNLTSSSLNDISDK
S262 SSSLNDISDKPEKDQ
K267 DISDKPEKDQLKNKF
K331 LFILLGPKGKAKSYH
K359 VFHDIAYKAKDRHDL
K395 AIRIEPPKSLPSSDK
K404 LPSSDKRKNMYSGGE
K448 RFCGGLIKDIKRKAP
K934 KLLLMPLKHQPDFIY
S1026 KKKKKKGSLDSDNDD
S1029 KKKGSLDSDNDDEKD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S1060 LESLGLPSPPRSPVK
S1064 GLPSPPRSPVKVVPQ
K1067 SPPRSPVKVVPQIRI
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