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MTMR3 (human)

Overview MTMR3 Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis Cellular Component: membrane; cytoplasm; nucleolus; cytosol; nucleus Molecular Function: phosphatidylinositol-3-phosphatase activity; metal ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation Reference #:  Q13615 (UniProtKB) Alt. Names/Synonyms: FLJ32333; FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; KIAA0371; MTMR3; myotubularin related protein 3; Myotubularin-related protein 3; ZFYVE10; Zinc finger FYVE domain-containing protein 10; zinc finger, FYVE domain containing 10 Gene Symbols: MTMR3 Molecular weight: 133,619 Da Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MTMR3

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S8-p	MDEETRHsLECIQAN
0	1		S56-p	EDAIIALsNYRLHIK
0	4		S288-p	FPNGGDLsDVEFDSS
0	1		T611	PLSRLPKTRsyDNLT
0	10		S613-p	SRLPKTRsyDNLTtA
0	1		Y614-p	RLPKTRsyDNLTtAC
0	2		T618	TRsyDNLTtACDNTV
0	1		T619-p	RsyDNLTtACDNTVP
0	2		C632	VPLASRRCsDPSLNE
0	20		S633-p	PLASRRCsDPSLNEK
0	7		S647-p	KWQEHRRsLELSSLA
0	2		T670	ADSLGKPTRVPGGAE
0	3		T731-p	EKESRRKtPEASAIG
0	1		T902	VGSVVHRTSLGsTLS
0	1		S903	GSVVHRTSLGsTLSL
0	1		S906-p	VHRTSLGsTLSLTRs
0	1		S913-p	sTLSLTRsPCALPLA
0	1		S1064	ESQYLTSSLHFNGDF
0	1		T1076	GDFGDEVTSIPDSES
0	1		S1077	DFGDEVTSIPDSESN
0	1		S1081	EVTSIPDSESNLDQN
0	1		S1083	TSIPDSESNLDQNCL

	mouse
S8-p	MDEEMRHsLECIQAN
S56	EEAIIALSNYRLHIK
S288	FPNAGDLSDVEFDSS
T611-p	PLSRLPKtRsFDNLt
S613-p	SRLPKtRsFDNLttT
F614	RLPKtRsFDNLttTC
T618-p	tRsFDNLttTCENMV
T619-p	RsFDNLttTCENMVP
S632-p	VPLASRRssDPSLNE
S633-p	PLASRRssDPSLNEK
S647	KWQEHGRSLELSSFA
S670	MDSLRKPSRLLGGAE
M729	PLAKESSMAAEGPVV
T899-p	WDSVLHRtSsPGNTL
S901-p	SVLHRtSsPGNTLSL
N904	HRtSsPGNTLSLLQA
A911	NTLSLLQAPCALPLD
S1062-p	ESQYLTSsLRFNGDF
T1074-p	GDFGDEVtsIPDsEs
S1075-p	DFGDEVtsIPDsEsN
S1079-p	EVtsIPDsEsNLDQN
S1081-p	tsIPDsEsNLDQNCV

	rat
S4	____MRHSLECIQAN
S52	EDAIIALSNYRLHIK
S284	FPNAGDLSDVEFDAS
T607	PLSRLPKTRSFDNLT
S609	SRLPKTRSFDNLTTT
F610	RLPKTRSFDNLTTTC
T614	TRSFDNLTTTCDNMV
T615	RSFDNLTTTCDNMVP
S628	VPLASRRSSDPSLNE
S629	PLASRRSSDPSLNEK
S643	KWQEHGRSLELSSFA
S666-p	IDSLRRPsRLLGGAE
T725	PLAKESRTAAQGSGV
T896	WDSVLHRTSSPGNTL
S898	SVLHRTSSPGNTLSL
N901	HRTSSPGNTLSLMMQ
A909	TLSLMMQAPCALPLD
S1060	ESQYLTSSLRFNGDF
T1072	GDFGDEVTSIPDSES
S1073	DFGDEVTSIPDSESN
S1077	EVTSIPDSESNLDQN
S1079	TSIPDSESNLDQNCL

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