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Protein Page:
MTMR3 (human)

Overview
MTMR3 Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis
Cellular Component: membrane; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; metal ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity
Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation
Reference #:  Q13615 (UniProtKB)
Alt. Names/Synonyms: FLJ32333; FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; KIAA0371; MTMR3; myotubularin related protein 3; Myotubularin-related protein 3; ZFYVE10; Zinc finger FYVE domain-containing protein 10; zinc finger, FYVE domain containing 10
Gene Symbols: MTMR3
Molecular weight: 133,619 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MTMR3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S8-p MDEETRHsLECIQAN
0 1 S56-p EDAIIALsNYRLHIK
0 4 S288-p FPNGGDLsDVEFDSS
0 5 T611-p PLSRLPKtRsyDNLt
0 15 S613-p SRLPKtRsyDNLttA
0 2 Y614-p RLPKtRsyDNLttAC
0 4 T618-p tRsyDNLttACDNtV
0 1 T619-p RsyDNLttACDNtVP
0 1 A620 syDNLttACDNtVPL
0 1 T624-p LttACDNtVPLASRR
0 2 C632 VPLASRRCsDPSLNE
0 25 S633-p PLASRRCsDPSLNEK
0 11 S647-p KWQEHRRsLELsSLA
0 1 S651-p HRRsLELsSLAGPGE
0 2 T670 ADSLGKPTRVPGGAE
0 1 S701-p QEATKEEsGVEEPAH
0 6 T731-p EKESRRKtPEAsAIG
0 1 S735-p RRKtPEAsAIGLHQD
0 1 S757-p LRSHLDMsWPLFSQG
0 1 S788-p VPPRGEDsLEVPVEQ
0 2 T902-p VGSVVHRtsLGsTLs
0 2 S903-p GSVVHRtsLGsTLsL
0 3 S906-p VHRtsLGsTLsLTRs
0 1 T907 HRtsLGsTLsLTRsP
0 2 S909-p tsLGsTLsLTRsPCA
0 3 S913-p sTLsLTRsPCALPLA
0 3 S975-p DSLSRQLsAMSCSSA
0 1 S996-p LHHKWLHsHSGRPSA
0 1 S1064 ESQYLTSSLHFNGDF
0 1 T1076 GDFGDEVTSIPDSES
0 1 S1077 DFGDEVTSIPDSESN
0 1 S1081 EVTSIPDSESNLDQN
0 1 S1083 TSIPDSESNLDQNCL
  mouse

 
S8-p MDEEMRHsLECIQAN
S56 EEAIIALSNYRLHIK
S288 FPNAGDLSDVEFDSS
T611-p PLSRLPKtRsFDNLt
S613-p SRLPKtRsFDNLttt
F614 RLPKtRsFDNLtttC
T618-p tRsFDNLtttCENMV
T619-p RsFDNLtttCENMVP
T620-p sFDNLtttCENMVPL
M624 LtttCENMVPLASRR
S632-p VPLASRRssDPSLNE
S633-p PLASRRssDPSLNEK
S647 KWQEHGRSLELSSFA
S651 HGRSLELSSFASAGE
S670 MDSLRKPSRLLGGAE
S701 QEATKEESGVEEPTH
M729 PLAKESSMAAEGPVV
P734 SSMAAEGPVVLYQEP
S755 LRSHQGPSLSLFSQG
S786 APLRGEDSQEVPVEQ
T899-p WDSVLHRtSsPGNtL
S901-p SVLHRtSsPGNtLSL
N904 HRtSsPGNtLSLLQA
T905-p RtSsPGNtLSLLQAP
S907 SsPGNtLSLLQAPCA
A911 NtLSLLQAPCALPLD
S973 DSLSHQLSATSCSSA
S994 LHHKWLNSHSGRPST
S1062-p ESQYLTSsLRFNGDF
T1074-p GDFGDEVtsIPDsEs
S1075-p DFGDEVtsIPDsEsN
S1079-p EVtsIPDsEsNLDQN
S1081-p tsIPDsEsNLDQNCV
  rat

 
S4 ____MRHSLECIQAN
S52 EDAIIALSNYRLHIK
S284 FPNAGDLSDVEFDAS
T607 PLSRLPKTRsFDNLT
S609-p SRLPKTRsFDNLTTT
F610 RLPKTRsFDNLTTTC
T614 TRsFDNLTTTCDNMV
T615 RsFDNLTTTCDNMVP
T616 sFDNLTTTCDNMVPL
M620 LTTTCDNMVPLASRR
S628-p VPLASRRssDPSLNE
S629-p PLASRRssDPSLNEK
S643 KWQEHGRSLELSSFA
S647 HGRSLELSSFAGSGE
S666-p IDSLRRPsRLLGGAE
S697 QEATKEESGVEEPTH
T725 PLAKESRTAAQGSGV
S730 SRTAAQGSGVLYQEP
S751 LRSHLGPSLSSFSQG
S783 ASLRGEDSQEVPVEQ
T896 WDSVLHRTSSPGNTL
S898 SVLHRTSSPGNTLSL
N901 HRTSSPGNTLSLMMQ
T902 RTSSPGNTLSLMMQA
S904 SSPGNTLSLMMQAPC
A909 TLSLMMQAPCALPLD
S971 DSLSHQLSATSYSSA
S992 LHHKWLNSHSGRPST
S1060 ESQYLTSSLRFNGDF
T1072 GDFGDEVTSIPDSES
S1073 DFGDEVTSIPDSESN
S1077 EVTSIPDSESNLDQN
S1079 TSIPDSESNLDQNCL
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