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Protein Page:
DNAJC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNAJC2 Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA replication; Cell cycle regulation; Chaperone
Cellular Component: nuclear membrane; cytoplasm; nucleus; cytosol
Molecular Function: ubiquitin binding; DNA binding; histone binding; Hsp70 protein binding; chromatin binding
Biological Process: 'de novo' cotranslational protein folding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of cell growth; chromatin modification; DNA replication
Reference #:  Q99543 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; DNAJC2; DNJC2; M-phase phosphoprotein 11; MPHOSPH11; MPP11; ZRF1; ZUO1; zuotin related factor 1; Zuotin-related factor 1
Gene Symbols: DNAJC2
Molecular weight: 71,996 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNAJC2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K40-ub RWFEAFVkRRNRNAs
1 405 S47-p kRRNRNAsAsFQELE
0 27 A48 RRNRNAsAsFQELED
0 120 S49-p RNRNAsAsFQELEDK
0 50 S60-p LEDKKELsEEsEDEE
0 52 S63-p KKELsEEsEDEELQL
0 16 Y90-p DWKNQDHyAVLGLGH
0 1 Y100-p LGLGHVRyKATQRQI
0 12 Y137-p IKEGDNDyFTCItKA
0 1 T142-p NDyFTCItKAYEMLS
0 2 K171-ub FDNSVPSkSEAkDNF
0 3 K175-ub VPSkSEAkDNFFEVF
0 17 T183-p DNFFEVFtPVFERNS
0 3 Y274-p RTLVDNAySCDPRIK
0 1 K413 VGKAALEKQIEEINE
0 1 T539-p VPQADNAtPSERFEG
0 14 Y548-p SERFEGPyTDFTPWT
0 1 K567-ub KLLEQALkTYPVNtP
0 1 T573-p LkTYPVNtPERWEKI
0 2 S617-p QEQVLNAsRAKK___
12397 : Phospho-DNAJC2/MPP11 (Ser47) Antibody
  mouse

 
K40 RWFEAFVKRRNRNAs
S47-p KRRNRNAstsFQELE
T48-p RRNRNAstsFQELED
S49-p RNRNAstsFQELEDK
S60-p LEDKKELsEEsEDEE
S63-p KKELsEEsEDEELQL
Y90 DWKNQDHYAVLGLGH
Y100 LGLGHVRYTATQRQI
Y137 IKEGDNDYFTCITKA
T142 NDYFTCITKAYEMLS
K171 FDNSVPSKSEAKDNF
K175 VPSKSEAKDNFFQVF
S183-p DNFFQVFsPVFERNS
Y274 RTLVDNAYSCDPRIK
K413-ub VGKAALEkQIEEVNE
A539 ASQADSAAPSERFEG
C548 SERFEGPCIDSTPWT
K567 KLLEQALKTYPVNTP
T573 LKTYPVNTPERWEKI
S617 QEQVLNASRARK___
12397 : Phospho-DNAJC2/MPP11 (Ser47) Antibody
  rat

 
K40 RWFEAFVKRRNRNAs
S47-p KRRNRNAsTsFQELE
T48 RRNRNAsTsFQELED
S49-p RNRNAsTsFQELEDK
S60-p LEDKKELsEEsEDEE
S63-p KKELsEEsEDEELQL
Y90 DWKNQDHYAVLGLGH
Y100 LGLGHVRYKATQRQI
Y137 IKEGDNDYFTCITKA
T142 NDYFTCITKAYEMLS
K171 FDNSVPSKSEAKENF
K175 VPSKSEAKENFFQVF
S183-p ENFFQVFsPVFERNS
Y274 RTLVDNAYSCDPRIK
K413 VGKAALEKQIEEVNE
A539 APQADSAAPSERFEG
C548 SERFEGPCIDSIPWT
K567 KLLEQALKTYPVNTP
T573 LKTYPVNTPERWEKI
S617 QEQVLNASRARK___
12397 : Phospho-DNAJC2/MPP11 (Ser47) Antibody
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