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DNAJC2
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; DNA replication; Chaperone |
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Cellular Component: nuclear membrane; cytoplasm; cytosol; nucleus
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Molecular Function: ubiquitin binding; DNA binding; histone binding; Hsp70 protein binding; chromatin binding
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Biological Process: 'de novo' cotranslational protein folding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; chromatin modification; negative regulation of cell growth; DNA replication; G2 phase of mitotic cell cycle
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Reference #:
Q99543 (UniProtKB)
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| Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; DNAJC2; DNJC2; M-phase phosphoprotein 11; MPHOSPH11; MPP11; ZRF1; ZUO1; zuotin related factor 1; Zuotin-related factor 1 |
| Gene Symbols: DNAJC2 |
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Molecular weight: 71,996 Da
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Basal Isoelectric point: 8.85
Predict pI for various phosphorylation states
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