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HMGA2 (human)

Overview HMGA2 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nuclear chromosome; nucleus Molecular Function: protein binding; DNA-(apurinic or apyrimidinic site) lyase activity; nucleosomal DNA binding; DNA binding; AT DNA binding; DNA-dependent protein kinase activity; 5'-deoxyribose-5-phosphate lyase activity; SMAD binding; DNA bending activity; transcription factor binding Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; cell proliferation in forebrain; multicellular organismal development; mesodermal cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of multicellular organism growth; regulation of growth hormone secretion; regulation of transcription, DNA-dependent; base-excision repair; chondrocyte differentiation; mitosis; negative regulation of retroviral genome replication; adrenal gland development; response to virus; heterochromatin formation; male gonad development; DNA damage response, detection of DNA damage; stem cell differentiation; negative regulation of DNA binding; chromosome condensation; mesenchymal cell differentiation; pituitary gland development; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of astrocyte differentiation; chromosome breakage; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis Reference #:  P52926 (UniProtKB) Alt. Names/Synonyms: BABL; high mobility group AT-hook 2; High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; HMGA2; HMGI-C; HMGIC; LIPO; STQTL9 Gene Symbols: HMGA2 Molecular weight: 11,832 Da Basal Isoelectric point: 10.63  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HMGA2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S2-a	______MsARGEGAG
0	1		S2-p	______MsARGEGAG
0	1		S12-p	GEGAGQPstsAQGQP
0	1		T13-p	EGAGQPstsAQGQPA
0	1		S14-p	GAGQPstsAQGQPAA
0	25		K26-a	PAAPAPQkRGRGRPR
0	1		K26-u	PAAPAPQkRGRGRPR
0	2		R27	AAPAPQkRGRGRPRK
0	1		T40-p	RKQQQEPtGEPsPKR
1	14		S44-p	QEPtGEPsPKRPRGR
1	0		S59	PKGSKNKSPSKAAQK
0	1		T97-p	KKPAQEEtEEtssQE
1	7		T100-p	AQEEtEEtssQEsAE
1	8		S101-p	QEEtEEtssQEsAEE
1	7		S102-p	EEtEEtssQEsAEED
1	18		S105-p	EEtssQEsAEED___

	HMGA2 iso2
S2	______MSARGEGAG
S2	______MSARGEGAG
S12	GEGAGQPSTSAQGQP
T13	EGAGQPSTSAQGQPA
S14	GAGQPSTSAQGQPAA
K26-a	PAAPAPQkRGRGRPR
K26	PAAPAPQKRGRGRPR
R27	AAPAPQkRGRGRPRK
T40	RKQQQEPTGEPSPKR
S44	QEPTGEPSPKRPRGR
S59	PKGSKNKSPSKAAQK
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
S2	______MSARGEGAG
S2	______MSARGEGAG
S12	GEGAGQPSTSAQGQP
T13	EGAGQPSTSAQGQPA
S14	GAGQPSTSAQGQPAA
K26-a	PAAPVPQkrGRGRPR
K26	PAAPVPQKrGRGRPR
R27-m1	AAPVPQkrGRGRPRK
T40	RKQQQEPTCEPsPKR
S44-p	QEPTCEPsPKRPRGR
S59-p	PKGSKNKsPSKAAQK
T96	QKKPAQETEEtssQE
T99-p	PAQETEEtssQEsAE
S100-p	AQETEEtssQEsAEE
S101-p	QETEEtssQEsAEED
S104-p	EEtssQEsAEED___

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