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Protein Page:
HMGA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HMGA2 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleoplasm; nuclear chromosome; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; enzyme binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding; DNA-dependent protein kinase activity; SMAD binding; 5'-deoxyribose-5-phosphate lyase activity; DNA bending activity; transcription factor binding
Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; positive regulation of apoptosis; cell proliferation in forebrain; positive regulation of transcription, DNA-dependent; multicellular organismal development; mesodermal cell differentiation; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of growth hormone secretion; regulation of transcription, DNA-dependent; base-excision repair; chondrocyte differentiation; negative regulation of retroviral genome replication; mitosis; negative regulation of steroid hormone receptor signaling pathway; transcription, DNA-dependent; adrenal gland development; response to virus; heterochromatin formation; male gonad development; DNA damage response, detection of DNA damage; stem cell differentiation; DNA catabolic process, endonucleolytic; negative regulation of DNA binding; chromosome condensation; mesenchymal cell differentiation; pituitary gland development; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of astrocyte differentiation; chromosome breakage; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of JAK-STAT cascade; negative regulation of apoptosis
Reference #:  P52926 (UniProtKB)
Alt. Names/Synonyms: BABL; high mobility group AT-hook 2; High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; HMGA2; HMGI-C; HMGIC; LIPO; STQTL9
Gene Symbols: HMGA2
Molecular weight: 11,832 Da
Basal Isoelectric point: 10.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HMGA2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S2-p ______MsARGEGAG
0 1 S2-ac ______MsARGEGAG
0 1 S12-p GEGAGQPstsAQGQP
0 1 T13-p EGAGQPstsAQGQPA
0 1 S14-p GAGQPstsAQGQPAA
0 25 K26-ac PAAPAPQkRGRGRPR
0 1 K26-ub PAAPAPQkRGRGRPR
0 2 R27 AAPAPQkRGRGRPRK
0 2 T40-p RKQQQEPtGEPsPKR
1 16 S44-p QEPtGEPsPKRPRGR
1 0 S59 PKGSKNKSPSKAAQK
0 1 T97-p KKPAQEEtEEtssQE
1 8 T100-p AQEEtEEtssQEsAE
1 9 S101-p QEEtEEtssQEsAEE
1 8 S102-p EEtEEtssQEsAEED
1 21 S105-p EEtssQEsAEED___
  HMGA2 iso2  
S2 ______MSARGEGAG
S2 ______MSARGEGAG
S12 GEGAGQPSTSAQGQP
T13 EGAGQPSTSAQGQPA
S14 GAGQPSTSAQGQPAA
K26-ac PAAPAPQkRGRGRPR
K26 PAAPAPQKRGRGRPR
R27 AAPAPQkRGRGRPRK
T40 RKQQQEPTGEPSPKR
S44 QEPTGEPSPKRPRGR
S59 PKGSKNKSPSKAAQK
- gap
- gap
- gap
- gap
- gap
  mouse

 
S2 ______MSARGEGAG
S2 ______MSARGEGAG
S12 GEGAGQPSTSAQGQP
T13 EGAGQPSTSAQGQPA
S14 GAGQPSTSAQGQPAA
K26-ac PAAPVPQkrGRGRPR
K26 PAAPVPQKrGRGRPR
R27-m1 AAPVPQkrGRGRPRK
T40 RKQQQEPTCEPsPKR
S44-p QEPTCEPsPKRPRGR
S59-p PKGSKNKsPSKAAQK
T96 QKKPAQETEEtssQE
T99-p PAQETEEtssQEsAE
S100-p AQETEEtssQEsAEE
S101-p QETEEtssQEsAEED
S104-p EEtssQEsAEED___
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