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FABP1 (human)

Overview FABP1 Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Note: This description may include information from UniProtKB. Protein type: Lipid binding protein Cellular Component: nucleoplasm; peroxisomal matrix; apical cortex; cytosol Molecular Function: antioxidant activity; bile acid binding; phospholipid binding; long-chain fatty acid transporter activity; drug binding; chromatin binding; fatty acid binding Biological Process: positive regulation of hydrolase activity; positive regulation of cell proliferation; negative regulation of caspase activity; cellular lipid metabolic process; negative regulation of apoptosis; intestinal absorption; positive regulation of fatty acid beta-oxidation Reference #:  P07148 (UniProtKB) Alt. Names/Synonyms: FABP1; FABPL; fatty acid binding protein 1, liver; Fatty acid-binding protein 1; Fatty acid-binding protein, liver; L-FABP; Liver-type fatty acid-binding protein Gene Symbols: FABP1 Molecular weight: 14,208 Da Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FABP1 2F73 - A/B/C/D/E/F/G/H=1-127 (human) 2L67 - A=2-127 (human) 2L68 - A=2-127 (human) 2LKK - A=2-127 (human) 2PY1 - A=1-127 (human) 3B2H - A=2-127 (human) 3B2I - A=2-127 (human) 3B2J - A=2-127 (human) 3B2K - A=2-127 (human) 3B2L - A=2-127 (human) 3STK - A=2-127 (human) 3STM - X=2-127 (human) 3STN - A=2-127 (human) 3VG2 - A=2-127 (human) 3VG3 - A=2-127 (human) 3VG4 - A=2-127 (human) 3VG5 - A=2-127 (human) 3VG6 - A=2-127 (human) 3VG7 - A=2-127 (human) 1LFO - A=1-127 (rat) 2JU3 - A=1-127 (rat) 2JU7 - A=1-127 (rat) 2JU8 - A=1-127 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2F73 2L67 2L68 2LKK 2PY1 3B2H 3B2I 3B2J 3B2K 3B2L 3STK 3STM 3STN 3VG2 3VG3 3VG4 3VG5 3VG6 3VG7  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K6	__MSFSGKYQLQsQE
0	1		K6	__MSFSGKYQLQsQE
0	3		S11-p	SGKYQLQsQENFEAF
0	2		K20-u	ENFEAFMkAIGLPEE
0	2		K31-u	LPEELIQkGkDIkGV
0	1		K33-a	EELIQkGkDIkGVSE
0	2		K36	IQkGkDIKGVSEIVQ
0	2		K36-u	IQkGkDIkGVSEIVQ
0	21		K46-a	SEIVQNGkHFKFTIt
0	2		K46-u	SEIVQNGkHFKFTIt
0	1		K49	VQNGkHFKFTItAGS
0	1		T51	NGkHFKFTItAGSKV
0	2		T53-p	kHFKFTItAGSKVIQ
0	2		A54	HFKFTItAGSKVIQN
0	1		S56	KFTItAGSKVIQNEF
0	1		K57	FTItAGSKVIQNEFT
0	1		K78	LETMTGEKVkTVVQL
0	2		K80-u	TMTGEKVkTVVQLEG
0	2		Q84	EKVkTVVQLEGDNKL
0	2		Q84	EKVkTVVQLEGDNKL
0	1		K90	VQLEGDNKLVTTFKN
0	1		K90	VQLEGDNKLVTTFKN
0	1		T94	GDNKLVTTFKNIkSV
0	2		K96	NKLVTTFKNIkSVTE
0	1		K96	NKLVTTFKNIkSVTE
0	1		K99	VTTFKNIKSVTELNG
0	2		K99-u	VTTFKNIkSVTELNG
0	2		S100	TTFKNIkSVTELNGD
0	11		K121-a	TLGDIVFkRISKRI_
0	1		K121	TLGDIVFKRISKRI_

	mouse
K6-a	__MNFSGkYQLQsQE
K6-u	__MNFSGkYQLQsQE
S11-p	SGkYQLQsQENFEPF
K20-u	ENFEPFMkAIGLPED
K31-u	LPEDLIQkGKDIkGV
K33	EDLIQkGKDIkGVSE
K36-a	IQkGKDIkGVSEIVH
K36-u	IQkGKDIkGVSEIVH
K46-a	SEIVHEGkKIkLtIt
K46-u	SEIVHEGkKIkLtIt
K49-u	VHEGkKIkLtItyGP
T51-p	EGkKIkLtItyGPkV
T53-p	kKIkLtItyGPkVVR
Y54-p	KIkLtItyGPkVVRN
P56	kLtItyGPkVVRNEF
K57-u	LtItyGPkVVRNEFT
K78-u	LETMTGEkVkAVVkL
K80-u	TMTGEkVkAVVkLEG
K84-a	EkVkAVVkLEGDNkM
K84-u	EkVkAVVkLEGDNkM
K90-a	VkLEGDNkMVTtFkG
K90-u	VkLEGDNkMVTtFkG
T94-p	GDNkMVTtFkGIksV
K96-a	NkMVTtFkGIksVTE
K96-u	NkMVTtFkGIksVTE
K99-a	VTtFkGIksVTELNG
K99-u	VTtFkGIksVTELNG
S100-p	TtFkGIksVTELNGD
K121-a	TLGDIVYkRVSKRI_
K121-u	TLGDIVYkRVSKRI_

	rat
K6	__MNFSGKYQVQsQE
K6	__MNFSGKYQVQsQE
S11-p	SGKYQVQsQENFEPF
K20	ENFEPFMKAMGLPED
K31	LPEDLIQKGKDIKGV
K33	EDLIQKGKDIKGVSE
K36	IQKGKDIKGVSEIVH
K36	IQKGKDIKGVSEIVH
K46	SEIVHEGKKVKLTIT
K46	SEIVHEGKKVKLTIT
K49	VHEGKKVKLTITYGs
T51	EGKKVKLTITYGsKV
T53	KKVKLTITYGsKVIH
Y54	KVKLTITYGsKVIHN
S56-p	KLTITYGsKVIHNEF
K57	LTITYGsKVIHNEFT
K78	LETMTGEKVKAVVKM
K80	TMTGEKVKAVVKMEG
K84	EKVKAVVKMEGDNKM
K84	EKVKAVVKMEGDNKM
K90	VKMEGDNKMVTTFKG
K90	VKMEGDNKMVTTFKG
T94	GDNKMVTTFKGIKSV
K96	NKMVTTFKGIKSVTE
K96	NKMVTTFKGIKSVTE
K99	VTTFKGIKSVTEFNG
K99	VTTFKGIKSVTEFNG
S100	TTFKGIKSVTEFNGD
K121	TLGDIVYKRVSKRI_
K121	TLGDIVYKRVSKRI_

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