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Protein Page:
GluR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GluR2 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, calcium; Channel, ligand-gated; Membrane protein, multi-pass
Cellular Component: postsynaptic membrane; endoplasmic reticulum membrane; synaptic vesicle; integral to plasma membrane; dendrite; plasma membrane; cell junction
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; signal transduction
Reference #:  P42262 (UniProtKB)
Alt. Names/Synonyms: AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; GRIA2; HBGR2
Gene Symbols: GRIA2
Molecular weight: 98,821 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GluR2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S880‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 Y285-p STLEEKEyPGAHTTT
1 0 S661 IESAEDLSKQTEIAY
1 0 S697 KMWTYMRSAEPSVFV
1 0 S717 GVARVRKSKGKYAYL
0 1 K850 AKRMKVAKNAQNINP
0 3 S860 QNINPSSSQNSQNFA
2 4 S863 NPSSSQNSQNFATYK
0 5 Y869 NSQNFATYKEGYNVy
0 1 K870 SQNFATYKEGYNVyG
2 112 Y876-p YKEGYNVyGIEsVKI
21 1 S880-p YNVyGIEsVKI____
0 1 - gap
0 1 - gap
0 2 - gap
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
4027 : Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody
  GluR2 iso2  
Y285 STLEEKEYPGAHTTT
S661 IESAEDLSKQTEIAY
S697 KMWTYMRSAEPSVFV
S717 GVARVRKSKGKYAYL
K850 AKRMKVAKNAQNINP
S860 QNINPSSSQNSQNFA
S863 NPSSSQNSQNFATYK
Y869 NSQNFATYKEGYNVY
K870 SQNFATYKEGYNVYG
Y876 YKEGYNVYGIESVKI
S880 YNVYGIESVKI____
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
Y285 STLEEKEYPGAHTAT
S661 IESAEDLSKQTEIAY
S697 KMWTYMRSAEPSVFV
S717 GVARVRKSKGKYAYL
K850-u AKRMKVAkNAQNINP
S860-p QNINPSSsQNsQNFA
S863-p NPSSsQNsQNFATyk
Y869-p NsQNFATykEGYNVy
K870-u sQNFATykEGYNVyG
Y876-p ykEGYNVyGIEsVKI
S880-p YNVyGIEsVKI____
- gap
- gap
- gap
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
4027 : Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody
  GluR2 iso3  
Y285 STLEEKEYPGAHTAT
S661 IESAEDLSKQTEIAY
S697 KMWTYMRSAEPSVFV
S717 GVARVRKSKGKYAYL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S899-p TRNKARLsITGsTGE
S903-p ARLsITGsTGENGRV
T912-p GENGRVMtPEFPKAV
  rat

 
Y285 STLEEKEYPGAHTAT
S661-p IESAEDLsKQTEIAY
S697-p KMWTYMRsAEPSVFV
S717-p GVARVRKsKGKYAYL
K850 AKRMKVAKNPQNINP
S860-p QNINPSSsQNsQNFA
S863-p NPSSsQNsQNFATyK
Y869-p NsQNFATyKEGYNVy
K870 sQNFATyKEGYNVyG
Y876-p yKEGYNVyGIEsVKI
S880-p YNVyGIEsVKI____
- gap
- gap
- gap
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
4027 : Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody
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