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Protein Page:
GluR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GluR2 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass; Channel, ligand-gated
Cellular Component: postsynaptic membrane; endoplasmic reticulum membrane; synaptic vesicle; integral to plasma membrane; dendrite; plasma membrane; cell junction
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; signal transduction
Reference #:  P42262 (UniProtKB)
Alt. Names/Synonyms: AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; GRIA2; HBGR2
Gene Symbols: GRIA2
Molecular weight: 98,821 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GluR2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S880‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S194 KKDEMYRSLFQDLEL
0 1 T279-p KFIERWStLEEKEyP
0 2 Y285-p StLEEKEyPGAHTtt
0 1 T291-p EyPGAHTttIKYTSA
0 1 T292-p yPGAHTttIKYTSAL
0 1 K379 TINIMELKTNGPRKI
1 0 S661 IESAEDLSKQTEIAY
1 0 S697 KMWTYMRSAEPSVFV
1 0 S717 GVARVRKSKGKYAYL
0 1 - gap
0 1 - gap
0 1 K850 AKRMKVAKNAQNINP
0 2 S860 QNINPSSSQNSQNFA
2 4 S863 NPSSSQNSQNFATYK
0 5 Y869 NSQNFATYKEGYNVy
0 1 K870 SQNFATYKEGYNVyG
2 111 Y876-p YKEGYNVyGIEsVKI
21 1 S880-p YNVyGIEsVKI____
0 1 K882 VyGIEsVKI______
0 1 - gap
0 1 - gap
0 2 - gap
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
4027 : Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody
  GluR2 iso2  
S194 KKDEMYRSLFQDLEL
T279 KFIERWSTLEEKEYP
Y285 STLEEKEYPGAHTTT
T291 EYPGAHTTTIKYTSA
T292 YPGAHTTTIKYTSAL
K379 TINIMELKTNGPRKI
S661 IESAEDLSKQTEIAY
S697 KMWTYMRSAEPSVFV
S717 GVARVRKSKGKYAYL
T765-p PKGSSLRtPVNLAVL
S775-p NLAVLKLsEQGVLDK
K850 AKRMKVAKNAQNINP
S860 QNINPSSSQNSQNFA
S863 NPSSSQNSQNFATYK
Y869 NSQNFATYKEGYNVY
K870 SQNFATYKEGYNVYG
Y876 YKEGYNVYGIESVKI
S880 YNVYGIESVKI____
K882 VYGIESVKI______
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S194-p KKDETYRsLFQDLEL
T279 KFIERWSTLEEKEYP
Y285 STLEEKEYPGAHTAT
A291 EYPGAHTATIKYTSA
T292 YPGAHTATIKYTSAL
K379-m1 TINIMELkTNGPRKI
S661 IESAEDLSKQTEIAY
S697 KMWTYMRSAEPSVFV
S717 GVARVRKSKGKYAYL
- gap
- gap
K850-ub AKRMKVAkNAQNINP
S860-p QNINPSSsQNsQNFA
S863-p NPSSsQNsQNFATyk
Y869-p NsQNFATykEGYNVy
K870-ub sQNFATykEGYNVyG
Y876-p ykEGYNVyGIEsVKI
S880-p YNVyGIEsVKI____
K882 VyGIEsVKI______
- gap
- gap
- gap
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
4027 : Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody
  GluR2 iso3  
S194 KKDETYRSLFQDLEL
T279 KFIERWSTLEEKEYP
Y285 STLEEKEYPGAHTAT
A291 EYPGAHTATIKYTSA
T292 YPGAHTATIKYTSAL
K379 TINIMELKTNGPRKI
S661 IESAEDLSKQTEIAY
S697 KMWTYMRSAEPSVFV
S717 GVARVRKSKGKYAYL
T803 SGGGDSKTPVNLAVL
S813 NLAVLKLSEQGVLDK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S899-p TRNKARLsITGsTGE
S903-p ARLsITGsTGENGRV
T912-p GENGRVMtPEFPKAV
  rat

 
S194 KKDETYRSLFQDLEL
T279 KFIERWSTLEEKEYP
Y285 STLEEKEYPGAHTAT
A291 EYPGAHTATIKYTSA
T292 YPGAHTATIKYTSAL
K379 TINIMELKTNGPRKI
S661-p IESAEDLsKQTEIAY
S697-p KMWTYMRsAEPSVFV
S717-p GVARVRKsKGKYAYL
- gap
- gap
K850 AKRMKVAKNPQNINP
S860 QNINPSSSQNsQNFA
S863-p NPSSSQNsQNFATyK
Y869-p NsQNFATyKEGYNVy
K870 sQNFATyKEGYNVyG
Y876-p yKEGYNVyGIEsVkI
S880-p YNVyGIEsVkI____
K882-ub VyGIEsVkI______
- gap
- gap
- gap
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
3921 : Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody
4027 : Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody
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