Home

GluR2 (human)

Overview GluR2 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Note: This description may include information from UniProtKB. Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, integral Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; synaptic vesicle membrane; integral to plasma membrane; postsynaptic density; terminal button; perikaryon; presynaptic membrane; asymmetric synapse; postsynaptic membrane; growth cone; plasma membrane; dendritic shaft; cell junction Molecular Function: kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; glutamate receptor activity; protein kinase binding Biological Process: synaptic transmission; ionotropic glutamate receptor signaling pathway; signal transduction Reference #:  P42262 (UniProtKB) Alt. Names/Synonyms: AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; GLUR2; GLURB; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; GRIA2; HBGR2 Gene Symbols: GRIA2 Molecular weight: 98,821 Da Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GluR2 2WJW - A=25-412 (human) 2WJX - A/C/B=25-412 (human) 2XHD - A/B=653-796 (human) 3R7X - A/B=653-796 (human) 3RN8 - A/C/B=653-812 (human) 3RNN - A/C/B=653-812 (human) 3UA8 - A=653-796 (human) 1FTJ - A/B/C=413-796 (rat) 1FTK - A=404-796 (rat) 1FTL - A/B=413-796 (rat) 1FTM - A/B/C=413-796 (rat) 1FTO - A/B=413-796 (rat) 1FW0 - A=413-796 (rat) 1GR2 - A=404-796 (rat) 1LB8 - A/B=413-796 (rat) 1LB9 - A/B=413-796 (rat) 1LBB - A=413-796 (rat) 1LBC - A/B/C=413-796 (rat) 1M5B - A/B/C=413-796 (rat) 1M5C - A=413-796 (rat) 1M5D - A=413-796 (rat) 1M5E - A/B/C=413-796 (rat) 1M5F - A/B/C=413-796 (rat) 1MM6 - A/B=413-796 (rat) 1MM7 - A/B/C=413-796 (rat) 1MQD - A/B/C/D=413-794 (rat) 1MQG - A/B=413-796 (rat) 1MQH - A=413-796 (rat) 1MQI - A=413-796 (rat) 1MQJ - A=413-796 (rat) 1MS7 - A/B/C=413-796 (rat) 1MXU - A/B/C=413-796 (rat) 1MXV - A/B/C=413-796 (rat) 1MXW - A/B/C=413-796 (rat) 1MXX - A/B/C=413-796 (rat) 1MXY - A/B/C=413-796 (rat) 1MXZ - A/B/C=413-796 (rat) 1MY0 - A/B/C=413-796 (rat) 1MY1 - A/B/C=413-796 (rat) 1MY2 - A/B/C=413-796 (rat) 1MY3 - A/B/C=413-796 (rat) 1MY4 - A/B/C=413-796 (rat) 1N0T - A/B/C=413-796 (rat) 1NNK - A=413-796 (rat) 1NNP - A/B=413-796 (rat) 1P1N - A=413-796 (rat) 1P1O - A=413-796 (rat) 1P1Q - A/B/C=413-796 (rat) 1P1U - A/B=413-796 (rat) 1P1W - A/B=413-796 (rat) 1SYH - A=413-796 (rat) 1SYI - A/B=413-796 (rat) 1WVJ - A=652-796 (rat) 1XHY - A=413-796 (rat) 2AIX - A=413-796 (rat) 2AL4 - A/B/C/D/E/F=413-796 (rat) 2AL5 - A/B=413-796 (rat) 2ANJ - A=413-796 (rat) 2CMO - A/B=413-796 (rat) 2GFE - A/B/C=652-795 (rat) 2I3V - A/B/C/D=413-794 (rat) 2I3W - A/B=413-794 (rat) 2P2A - A/B=413-527, A/B=652-796 (rat) 2UXA - A/B/C=- (rat) 2XX7 - A/C/B=653-795 (rat) 2XX8 - A/C/B=653-796 (rat) 2XX9 - A/C/B=653-796 (rat) 2XXH - A/C/B=653-796 (rat) 2XXI - A/C/B=653-796 (rat) 3B6Q - A=653-796 (rat) 3B6T - A=653-796 (rat) 3B6W - A/D/C/B=653-796 (rat) 3B7D - F/A/E/B/H/C/D/G=653-794 (rat) 3BBR - A/B=653-796 (rat) 3BFT - A/C/B=653-796 (rat) 3BFU - A/D/C/B=653-796 (rat) 3BKI - D/C/P/B=653-796 (rat) 3DP6 - A/C/B=653-796 (rat) 3H03 - A/D/G/B=653-794 (rat) 3H06 - H/J/N/P/G/L/E/B=653-794 (rat) 3H5V - A/C/B=0-383 (rat) 3H5W - A/B=0-383 (rat) 3H6T - A/C/B=653-796 (rat) 3H6U - A=653-796 (rat) 3H6V - A/B=653-796 (rat) 3H6W - A/B=653-796 (rat) 3HSY - A/B=25-400 (rat) 3IJO - H/E/B=653-794 (rat) 3IJX - H/D/B=653-794 (rat) 3IK6 - H/E/B=653-794 (rat) 3IL1 - H/E/B=653-794 (rat) 3ILT - H/E/B=653-794 (rat) 3ILU - H/E/B=653-794 (rat) 3KG2 - A/D/C/B=25-847 (rat) 3KGC - A/B=654-795 (rat) 3LSF - H/E/B=653-794 (rat) 3LSL - A/D/G=653-794 (rat) 3M3L - A/D/G=652-794 (rat) 3N6V - F/A/D/C/E/B=27-400 (rat) 3O28 - A=653-795 (rat) 3O29 - A=653-795 (rat) 3O2A - A=653-795 (rat) 3O2J - A/B=22-400 (rat) 3O6G - A=653-795 (rat) 3O6H - A=653-795 (rat) 3O6I - A=653-795 (rat) 3PD8 - A/C/B=653-795 (rat) 3PD9 - A/B=653-795 (rat) 3PMV - A=653-796 (rat) 3PMW - A=653-796 (rat) 3PMX - A=653-796 (rat) 3RTF - F/D/B=653-794 (rat) 3RTW - F/D/B=653-794 (rat) 3T93 - F/D/B=653-794 (rat) 3T96 - F/D/B=653-794 (rat) 3T9H - F/D/B=653-794 (rat) 3T9U - A/C/B=653-794 (rat) 3T9V - A/B=653-794 (rat) 3T9X - F/D/B=653-794 (rat) 3TDJ - A/B=653-796 (rat) 3TKD - A/B=653-795 (rat) 3TZA - A/B=653-796 (rat) 4FAT - A=653-796 (rat) 4G8M - A/B=653-796 (rat) 4GXS - D/B=653-794 (rat) 4IGT - A=653-796 (rat) 4ISU - A/C/D/B=653-796 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
activation: S880‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S194	KKDEMYRSLFQDLEL
0	1		T279-p	KFIERWStLEEKEyP
0	2		Y285-p	StLEEKEyPGAHTtt
0	1		T291-p	EyPGAHTttIKYTSA
0	1		T292-p	yPGAHTttIKYTSAL
0	1		K379	TINIMELKTNGPRKI
1	0		S661	IESAEDLSKQTEIAY
1	0		S697	KMWTYMRSAEPSVFV
1	0		S717	GVARVRKSKGKYAYL
0	1		-	gap
0	1		-	gap
0	1		K850	AKRMKVAKNAQNINP
0	3		S860	QNINPSSSQNSQNFA
2	4		S863	NPSSSQNSQNFATYK
0	5		Y869	NSQNFATYKEGYNVy
0	1		K870	SQNFATYKEGYNVyG
2	112		Y876-p	YKEGYNVyGIEsVKI
19	1		S880-p	YNVyGIEsVKI____
0	1		K882	VyGIEsVKI______
0	1		-	gap
0	1		-	gap
0	2		-	gap

	GluR2 iso2
S194	KKDEMYRSLFQDLEL
T279	KFIERWSTLEEKEYP
Y285	STLEEKEYPGAHTTT
T291	EYPGAHTTTIKYTSA
T292	YPGAHTTTIKYTSAL
K379	TINIMELKTNGPRKI
S661	IESAEDLSKQTEIAY
S697	KMWTYMRSAEPSVFV
S717	GVARVRKSKGKYAYL
T765-p	PKGSSLRtPVNLAVL
S775-p	NLAVLKLsEQGVLDK
K850	AKRMKVAKNAQNINP
S860	QNINPSSSQNSQNFA
S863	NPSSSQNSQNFATYK
Y869	NSQNFATYKEGYNVY
K870	SQNFATYKEGYNVYG
Y876	YKEGYNVYGIESVKI
S880	YNVYGIESVKI____
K882	VYGIESVKI______
-	gap
-	gap
-	gap

	mouse ► Hide Isoforms
S194-p	KKDETYRsLFQDLEL
T279	KFIERWSTLEEKEYP
Y285	STLEEKEYPGAHTAT
A291	EYPGAHTATIKYTSA
T292	YPGAHTATIKYTSAL
K379-m1	TINIMELkTNGPRKI
S661	IESAEDLSKQTEIAY
S697	KMWTYMRSAEPSVFV
S717	GVARVRKSKGKYAYL
-	gap
-	gap
K850-u	AKRMKVAkNAQNINP
S860-p	QNINPSSsQNsQNFA
S863-p	NPSSsQNsQNFATyk
Y869-p	NsQNFATykEGYNVy
K870-u	sQNFATykEGYNVyG
Y876-p	ykEGYNVyGIEsVKI
S880-p	YNVyGIEsVKI____
K882	VyGIEsVKI______
-	gap
-	gap
-	gap

	GluR2 iso3
S194	KKDETYRSLFQDLEL
T279	KFIERWSTLEEKEYP
Y285	STLEEKEYPGAHTAT
A291	EYPGAHTATIKYTSA
T292	YPGAHTATIKYTSAL
K379	TINIMELKTNGPRKI
S661	IESAEDLSKQTEIAY
S697	KMWTYMRSAEPSVFV
S717	GVARVRKSKGKYAYL
T803	SGGGDSKTPVNLAVL
S813	NLAVLKLSEQGVLDK
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S899-p	TRNKARLsITGsTGE
S903-p	ARLsITGsTGENGRV
T912-p	GENGRVMtPEFPKAV

	rat
S194	KKDETYRSLFQDLEL
T279	KFIERWSTLEEKEYP
Y285	STLEEKEYPGAHTAT
A291	EYPGAHTATIKYTSA
T292	YPGAHTATIKYTSAL
K379	TINIMELKTNGPRKI
S661-p	IESAEDLsKQTEIAY
S697-p	KMWTYMRsAEPSVFV
S717-p	GVARVRKsKGKYAYL
-	gap
-	gap
K850	AKRMKVAKNPQNINP
S860-p	QNINPSSsQNsQNFA
S863-p	NPSSsQNsQNFATyK
Y869-p	NsQNFATyKEGYNVy
K870	sQNFATyKEGYNVyG
Y876-p	yKEGYNVyGIEsVkI
S880-p	YNVyGIEsVkI____
K882-u	VyGIEsVkI______
-	gap
-	gap
-	gap

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.