Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Belongs to the chloride channel CLIC family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: centrosome; cell surface; cytoplasmic vesicle membrane; nuclear matrix; microvillus; mitochondrion; intercellular junction; cytosol; actin cytoskeleton; microtubule cytoskeleton; apical part of cell; perinuclear region of cytoplasm; cytoplasm; plasma membrane; intracellular; midbody
Molecular Function: chloride channel activity; protein binding; voltage-gated ion channel activity
Biological Process: apoptosis; multicellular organism growth; chloride transport; establishment and/or maintenance of apical/basal cell polarity; keratinocyte differentiation; vacuolar acidification; fertilization; branching morphogenesis of a tube; angiogenesis; endothelial cell morphogenesis; cell differentiation; negative regulation of cell migration; regulation of cytoskeleton organization and biogenesis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.