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Protein Page:
CALU (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CALU Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity. Belongs to the CREC family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q32.1
Cellular Component: Golgi apparatus; sarcoplasmic reticulum lumen; membrane; endoplasmic reticulum; extracellular region; melanosome
Molecular Function: protein binding; calcium ion binding
Biological Process: platelet activation; platelet degranulation; blood coagulation
Reference #:  O43852 (UniProtKB)
Alt. Names/Synonyms: CALU; Calumenin; Crocalbin; crocalbin-like protein; FLJ90608; IEF SSP 9302; multiple EF-hand protein
Gene Symbols: CALU
Molecular weight: 37,107 Da
Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CALU

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S35-p VHHEPQLsDKVHNDA
1 9 S44-p KVHNDAQsFDyDHDA
0 6 Y47-p NDAQsFDyDHDAFLG
1 1 T60-p LGAEEAKtFDQLtPE
0 1 T60-ga LGAEEAKtFDQLtPE
0 7 T65-p AKtFDQLtPEEskER
0 9 S69-p DQLtPEEskERLGKI
0 1 K70-ub QLtPEEskERLGKIV
0 1 K84-ub VSKIDGDkDGFVTVD
0 1 K94-ub FVTVDELkDWIkFAQ
0 1 K98-ub DELkDWIkFAQKRWI
0 56 Y106-p FAQKRWIyEDVERQW
0 1 K114-ub EDVERQWkGHDLNED
0 1 S125-p LNEDGLVsWEEYKNA
0 1 K165 RRFKMADKDGDLIAT
1 0 T177-p IATKEEFtAFLHPEE
1 0 T196-p KDIVVQEtMEDIDKN
1 0 T224 MYSHDGNTDEPEWVK
1 1 T254-p GKMDKEEtkDWILPs
0 1 K255-ub KMDKEEtkDWILPsD
0 1 S261-p tkDWILPsDyDHAEA
0 1 S261-ga tkDWILPsDyDHAEA
0 6 Y263-p DWILPsDyDHAEAEA
0 65 Y275-p AEARHLVyEsDQNKD
0 3 S277-p ARHLVyEsDQNKDGK
0 2 S300-p KYDLFVGsQATDFGE
  CALU iso4  
S43 VHHEPQLSDKVHNDA
S52 KVHNDAQSFDYDHDA
Y55 NDAQSFDYDHDAFLG
T68-p LGAEEAKtFDQLtPE
T68 LGAEEAKTFDQLtPE
T73-p AKtFDQLtPEEsKER
S77-p DQLtPEEsKERLGMI
K78 QLtPEEsKERLGMIV
K92 VDKIDADKDGFVTEG
K102-ub FVTEGELkSWIKHAQ
K106 GELkSWIKHAQKKYI
Y114 HAQKKYIYDNVENQW
Q122 DNVENQWQEFDMNQD
S133 MNQDGLISWDEYRNV
K173 RRFKMADKDGDLIAT
T185 IATKEEFTAFLHPEE
T204 KDIVVQETMEDIDKN
T232 MYSHDGNTDEPEWVK
T262 GKMDKEETKDWILPS
K263 KMDKEETKDWILPSD
S269 TKDWILPSDYDHAEA
S269 TKDWILPSDYDHAEA
Y271 DWILPSDYDHAEAEA
Y283 AEARHLVYESDQNKD
S285 ARHLVYESDQNKDGK
S308 KYDLFVGSQATDFGE
  CALU iso15  
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
K14 RRFKMADKDGDLIAT
T26 IATKEEFTAFLHPEE
T45 KDIVVQETMEDIDKN
T73-p MYSHDGNtDEPEWVK
T103 GKMDKEETKDWILPS
K104 KMDKEETKDWILPSD
S110 TKDWILPSDYDHAEA
S110 TKDWILPSDYDHAEA
Y112 DWILPSDYDHAEAEA
Y124 AEARHLVYESDQNKD
S126 ARHLVYESDQNKDGK
S149 KYDLFVGSQATDFGE
  mouse

 
S35 VHHEPQLSDKVHNDA
N44 KVHNDAQNFDyDHDA
Y47-p NDAQNFDyDHDAFLG
S60 LGAEEAKSFDQLtPE
S60 LGAEEAKSFDQLtPE
T65-p AKSFDQLtPEEsKER
S69-p DQLtPEEsKERLGKI
K70 QLtPEEsKERLGKIV
K84 VSKIDDDKDGFVTVD
K94 FVTVDELKGWIKFAQ
K98 DELKGWIKFAQKRWI
H106 FAQKRWIHEDVERQW
K114 EDVERQWKGHDLNED
S125 LNEDGLVSWEEYKNA
K165-ac RRFKMADkDGDLIAT
T177 IATKEEFTAFLHPEE
T196 KDIVVQETMEDIDKN
A224 MYSHDGNADEPEWVK
T254 GKMDKEETKDWILPS
K255 KMDKEETKDWILPSD
S261 TKDWILPSDYDHAEA
S261 TKDWILPSDYDHAEA
Y263 DWILPSDYDHAEAEA
Y275-p AEARHLVyESDQNKD
S277 ARHLVyESDQNKDGK
S300 KYDLFVGSQATDFGE
  rat

 
S35 VHHEPQLSDKVHNDA
N44 KVHNDAQNFDyDHDA
Y47-p NDAQNFDyDHDAFLG
S60 LGAEEAKSFGQLTPE
S60 LGAEEAKSFGQLTPE
T65 AKSFGQLTPEESKEK
S69 GQLTPEESKEKLGMI
K70 QLTPEESKEKLGMIV
K84 VDKIDTDKDGFVTEG
K94 FVTEGELKSRIKHAQ
K98 GELKSRIKHAQKKYI
Y106 HAQKKYIYDNVENQW
Q114 DNVENQWQEFDMNQD
S125 MNQDGLISWDEYRNV
Q165 RRFKMADQDGDLIAT
T177 IATKEEFTAFLHPEE
T196 KDIVLQETMEDIDQN
A224 MYSHDGNADEPQWVK
T254 GKMDKEETKDWILPS
K255 KMDKEETKDWILPSD
S261 TKDWILPSDYDHAEA
S261 TKDWILPSDYDHAEA
Y263 DWILPSDYDHAEAEA
Y275 AEARHLVYESDQDKD
S277 ARHLVYESDQDKDGK
S300 KYDLFVGSQATDFGE
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