Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ABCB11 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCB11 Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease. Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2). BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Hydrolase; Transporter, ABC family; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 2q24
Cellular Component: intercellular canaliculus; membrane; apical part of cell; integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: transporter activity; ATPase activity, coupled to transmembrane movement of substances; canalicular bile acid transmembrane transporter activity; bile acid-exporting ATPase activity; sodium-exporting ATPase activity, phosphorylative mechanism; ATP binding
Biological Process: bile acid and bile salt transport; ATP catabolic process; bile acid biosynthetic process; bile acid metabolic process; transport; canalicular bile acid transport; transmembrane transport
Reference #:  O95342 (UniProtKB)
Alt. Names/Synonyms: ABC member 16, MDR/TAP subfamily; ABC16; ABCB11; ABCBB; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; Bile salt export pump; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; SPGP
Gene Symbols: ABCB11
Molecular weight: 146,407 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Select Structure to View Below

ABCB11

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K12 VILRSIKKFGEENDG
0 1 S25 DGFESDKSYNNDKKS
0 1 K30 DKSYNNDKKSRLQDE
0 1 K272 KFTDYELKAYAKAGV
0 1 K276 YELKAYAKAGVVADE
0 1 T290 EVISSMRTVAAFGGE
0 1 R299 AAFGGEKREVERYEK
0 1 K306 REVERYEKNLVFAQR
0 1 K412 CMSEDGYKLDRIKGE
0 1 K417 GYKLDRIKGEIEFHN
0 1 K436 YPSRPEVKILNDLNM
0 1 K446 NDLNMVIKPGEMTAL
0 1 T586-p ILLLDMAtsALDNEs
0 1 S587-p LLLDMAtsALDNEsE
0 1 S593-p tsALDNEsEAMVQEV
0 1 M596 LDNEsEAMVQEVLSK
0 2 T673 EEDIKDATEDDMLAR
0 4 M677 KDATEDDMLARTFsR
0 1 T681 EDDMLARTFsRGsYQ
0 4 S683-p DMLARTFsRGsYQDs
0 4 S686-p ARTFsRGsYQDsLRA
0 15 S690-p sRGsYQDsLRAsIRQ
0 9 S694-p YQDsLRAsIRQRSKS
0 1 S699 RAsIRQRSKSQLsYL
0 1 K700 AsIRQRSKSQLsYLV
0 3 S701 sIRQRSKSQLsYLVH
0 3 S704-p QRSKSQLsYLVHEPP
0 1 K718 PLAVVDHKSTYEEDR
0 1 K726 STYEEDRKDKDIPVQ
0 1 K788 GTFSIPDKEEQRSQI
0 1 R837 RLRKFGFRAMLGQDI
0 1 R851 IAWFDDLRNSPGALt
0 1 T858-p RNSPGALttRLATDA
0 1 T859-p NSPGALttRLATDAS
0 1 K930 TGFASRDKQALEMVG
0 2 M935 RDKQALEMVGQITNE
0 1 E961 GKERRFIEALETELE
0 1 K1043 SYTPSYAKAKISAAR
0 1 Q1058 FFQLLDRQPPISVYN
0 1 K1070 VYNTAGEKWDNFQGK
0 1 K1077 KWDNFQGKIDFVDCK
0 1 K1145 MIDGHDSKKVNVQFL
0 1 K1146 IDGHDSKKVNVQFLR
0 1 K1175 CSIMDNIKYGDNTKE
0 1 K1181 IKYGDNTKEIPMERV
0 1 K1193 ERVIAAAKQAQLHDF
0 1 K1207 FVMSLPEKYETNVGs
0 1 S1214-p KYETNVGsQGsQLSR
0 1 S1217-p TNVGsQGsQLSRGEK
0 1 K1238 RAIVRDPKILLLDEA
0 1 K1255 ALDTESEKTVQVALD
0 1 K1263 TVQVALDKAREGRTC
0 1 K1307 HEELMAQKGAYYKLV
0 1 K1307 HEELMAQKGAYYKLV
0 1 S1321 VTTGSPIS_______
  mouse

 
K12-ub VILRSVKkFGEENHA
F25 HAFESDGFHNNDkKS
K30-ub DGFHNNDkKSRLQDK
K272-ub KFTELELkAYAkAGS
K276-ub LELkAYAkAGSIADE
T290 EVLSSIRTVAAFGGE
K299-ub AAFGGENkEVERYEk
K306-ub kEVERYEkNLMFAQR
K412-ub CMSGDGYkLDRIkGE
K417-ub GYkLDRIkGEIEFHN
K436-ac YPSRPEVkILNNLSM
K446-ub NNLSMVIkPGETTAF
T586 ILLLDMATSALDNES
S587 LLLDMATSALDNESE
S593 TSALDNESEAkVQGA
K596-ub LDNESEAkVQGALNK
T675-p GIKGKDTtEGDtPER
T679-p KDTtEGDtPERtFsR
T683-p EGDtPERtFsRGsYQ
S685-p DtPERtFsRGsYQDs
S688-p ERtFsRGsYQDsLRA
S692-p sRGsYQDsLRAsIRQ
S696-p YQDsLRAsIRQRsks
S701-p RAsIRQRsksQLsHL
K702-ub AsIRQRsksQLsHLS
S703-p sIRQRsksQLsHLSH
S706-p QRsksQLsHLSHEPP
K720-ub PLAIGDHkSSYEDRk
K727-ub kSSYEDRkDNDVLVE
K788-ub KTFSLVDkEQQRSEI
K837-ub RLRKFGFkAMLRQDI
K851-ub IGWFDDLkNNPGVLT
T858 kNNPGVLTTRLATDA
T859 NNPGVLTTRLATDAS
K930-ub TGFASQDkEILEkAG
K935-ub QDkEILEkAGQITNE
K961-ub GVEGRFIkAFEVELE
K1043-ub SYTPSYAkAKISAAR
K1058-ub FFQLLDRkPPIDVYS
K1070-ub VYSGAGEkWDNFQGk
K1077-ub kWDNFQGkIDFIDCK
K1145-ub MIDGHDSkkVNVQFL
K1146-ub IDGHDSkkVNVQFLR
K1175-ub CSIMDNIkYGDNTkE
K1181-ub IkYGDNTkEISVERA
K1193-ub ERAIAAAkQAQLHDF
K1207-ub FVMSLPEkYETNVGI
I1214 kYETNVGIQGSQLSR
S1217 TNVGIQGSQLSRGEK
K1238-ub RAIVRDPkILLLDEA
K1255-ub ALDTESEkTVQLALD
K1263-ub TVQLALDkAREGRTC
K1307-ac HKKLMDQkGAYYKLV
K1307-ub HKKLMDQkGAYYKLV
S1321 VITGAPIS_______
  rat

 
K12 VILRSVKKFGEENHA
S25-p HAFESDGsHNNDKKS
K30 DGsHNNDKKSRLQDK
K272 KFTELELKAYAKAGS
K276 LELKAYAKAGSIADE
T290-p EVLSSIRtVAAFGGE
K299 AAFGGENKEVERYEK
K306 KEVERYEKNLVFAQR
K412 CMSGDGYKLDRIKGE
K417 GYKLDRIKGEIEFHN
K436 YPSRPDVKILDNLSM
K446 DNLSMVIKPGETTAL
T586 ILLLDMATSALDNES
S587 LLLDMATSALDNESE
S593 TSALDNESEARVQEA
R596 LDNESEARVQEALNK
T675 SIMGKDATEGGtLER
T679-p KDATEGGtLERTFSR
T683 EGGtLERTFSRGSYR
S685 GtLERTFSRGSYRDS
S688 ERTFSRGSYRDSLRA
S692 SRGSYRDSLRASIRQ
S696 YRDSLRASIRQRSKs
S701 RASIRQRSKsQLsLL
K702 ASIRQRSKsQLsLLT
S703-p SIRQRSKsQLsLLTH
S706-p QRSKsQLsLLTHDPP
K720 PLAVADHKSSYKDSK
K727 KSSYKDSKDNDVLVE
K788 GTFSLLDKEQQRSEI
K837 RLRKFGFKAMLGQDI
R851 IGWFDDLRNNPGVLT
T858 RNNPGVLTTRLATDA
T859 NNPGVLTTRLATDAS
K930 TGFASQDKQALEKAG
K935 QDKQALEKAGQITSE
K961 GVEGRFIKAFEVELQ
K1043 SYTPSYAKAKISAAR
K1058 FFQLLDRKPPINVYS
K1070 VYSEAGEKWDNFQGK
K1077 KWDNFQGKIDFIDCK
K1145 MIDGHDSKKVNIQFL
K1146 IDGHDSKKVNIQFLR
K1175 CSIMDNIKYGDNTKE
K1181 IKYGDNTKEISVERA
K1193 ERAIAAAKQAQLHDF
K1207 FVMSLPEKYETNVGI
I1214 KYETNVGIQGSQLSR
S1217 TNVGIQGSQLSRGEK
K1238 RAIVRDPKILLLDEA
K1255 ALDTESEKTVQTALD
K1263 TVQTALDKAREGRTC
K1307 HEKLMAQKGAYYKLV
K1307 HEKLMAQKGAYYKLV
S1321-p VITGAPIs_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.