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BNIP3L (human)

Overview BNIP3L Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family. Note: This description may include information from UniProtKB. Protein type: Mitochondrial; Nuclear envelope; Apoptosis; Endoplasmic reticulum; Membrane protein, integral Cellular Component: mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; integral to membrane; nuclear envelope; intrinsic to membrane Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; lamin binding Biological Process: apoptosis; virus-host interaction; induction of apoptosis; defense response to virus; negative regulation of apoptosis Reference #:  O60238 (UniProtKB) Alt. Names/Synonyms: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNI3L; BNIP3A; BNIP3H; BNIP3L; NIP3-like protein X; NIP3L; NIX Gene Symbols: BNIP3L Molecular weight: 23,930 Da Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BNIP3L

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	8		S62-p	GGLEHVPsSSSIHNG
0	3		S63	GLEHVPsSSSIHNGD
0	3		S64	LEHVPsSSSIHNGDM
0	4		S65	EHVPsSSSIHNGDME
0	2		S82	LLDAQHESGQSSSRG
0	9		S117	MHTSRDHSSQsEEEV
0	9		S118	HTSRDHSSQsEEEVV
0	13		S120-p	SRDHSSQsEEEVVEG
0	2		K154-u	RPENIPPkEFHFRHP
0	1		S164-p	HFRHPKRsVsLSMRK
0	8		S166-p	RHPKRsVsLSMRKSG
0	2		S168	PKRsVsLSMRKSGAM
0	1		K176-a	MRKSGAMkKGGIFSA
0	1		K177	RKSGAMkKGGIFSAE
0	1		Y219-p	STPSASTy_______

	mouse
S61-p	GGLEHVPssssIHNG
S62-p	GLEHVPssssIHNGD
S63-p	LEHVPssssIHNGDM
S64-p	EHVPssssIHNGDME
S81-p	LLDAQHEsGQSSSRG
S116-p	MHTSRDHssQsEEEV
S117-p	HTSRDHssQsEEEVV
S119-p	SRDHssQsEEEVVEG
K153	RPENIPPKEFHFRHP
A163	HFRHPKRAAsLsMRK
S165-p	RHPKRAAsLsMRKSG
S167-p	PKRAAsLsMRKSGAM
K175	MRKSGAMKkGGIFSA
K176-u	RKSGAMKkGGIFSAE
Y218	STPSASTY_______

	rat
S61	GGLEHVPSSSSIHNG
S62	GLEHVPSSSSIHNGD
S63	LEHVPSSSSIHNGDM
S64	EHVPSSSSIHNGDME
S81	LLDAQHESGQSSSRG
S116-p	MHTSRDHssQsEEEV
S117-p	HTSRDHssQsEEEVV
S119-p	SRDHssQsEEEVVDG
K153	RPENIPPKEFLFRHP
A163	LFRHPKRAASLSMRK
S165	RHPKRAASLSMRKSG
S167	PKRAASLSMRKSGAM
K175	MRKSGAMKKGGIFSA
K176	RKSGAMKKGGIFSAE
Y218	STPSASTY_______

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