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Protein Page:
BNIP3L (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BNIP3L Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Nuclear envelope; Membrane protein, integral; Apoptosis; Endoplasmic reticulum
Cellular Component: mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; integral to membrane; intrinsic to membrane; nuclear envelope
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; lamin binding
Biological Process: viral reproduction; positive regulation of apoptosis; defense response to virus; negative regulation of apoptosis
Reference #:  O60238 (UniProtKB)
Alt. Names/Synonyms: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNI3L; BNIP3A; BNIP3H; BNIP3L; NIP3-like protein X; NIP3L; NIX
Gene Symbols: BNIP3L
Molecular weight: 23,930 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BNIP3L

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 12 S62-p GGLEHVPssssIHNG
0 4 S63-p GLEHVPssssIHNGD
0 4 S64-p LEHVPssssIHNGDM
0 7 S65-p EHVPssssIHNGDME
0 3 S82-p LLDAQHEsGQSSSRG
0 13 S117-p MHTSRDHssQsEEEV
0 14 S118-p HTSRDHssQsEEEVV
0 18 S120-p SRDHssQsEEEVVEG
0 2 K154-ub RPENIPPkEFHFRHP
0 1 S164-p HFRHPKRsVsLsMRK
0 11 S166-p RHPKRsVsLsMRKSG
0 5 S168-p PKRsVsLsMRKSGAM
0 1 K176-ac MRKSGAMkKGGIFSA
0 1 K177 RKSGAMkKGGIFSAE
0 1 Y219-p STPSASTy_______
  mouse

 
S61-p GGLEHVPssssIHNG
S62-p GLEHVPssssIHNGD
S63-p LEHVPssssIHNGDM
S64-p EHVPssssIHNGDME
S81-p LLDAQHEsGQSSSRG
S116-p MHTSRDHssQsEEEV
S117-p HTSRDHssQsEEEVV
S119-p SRDHssQsEEEVVEG
K153 RPENIPPKEFHFRHP
A163 HFRHPKRAAsLsMRK
S165-p RHPKRAAsLsMRKSG
S167-p PKRAAsLsMRKSGAM
K175 MRKSGAMKkGGIFSA
K176-ub RKSGAMKkGGIFSAE
Y218 STPSASTY_______
  rat

 
S61-p GGLEHVPsSSsIHNG
S62 GLEHVPsSSsIHNGD
S63 LEHVPsSSsIHNGDM
S64-p EHVPsSSsIHNGDME
S81 LLDAQHESGQSSSRG
S116-p MHTSRDHssQsEEEV
S117-p HTSRDHssQsEEEVV
S119-p SRDHssQsEEEVVDG
K153 RPENIPPKEFLFRHP
A163 LFRHPKRAAsLSMRK
S165-p RHPKRAAsLSMRKSG
S167 PKRAAsLSMRKSGAM
K175 MRKSGAMKKGGIFSA
K176 RKSGAMKKGGIFSAE
Y218 STPSASTY_______
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