Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, integral
Cellular Component: mitochondrial envelope; mitochondrion; endoplasmic reticulum; dendrite; integral to membrane; nuclear envelope; nucleoplasm; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; GTPase binding; protein homodimerization activity; protein heterodimerization activity
Biological Process: cell death; positive regulation of protein complex disassembly; induction of apoptosis by granzyme; positive regulation of apoptosis; apoptosis; chromatin remodeling; positive regulation of programmed cell death; neuron apoptosis; autophagic cell death; brown fat cell differentiation; response to hypoxia; mitochondrial fragmentation during apoptosis; DNA fragmentation during apoptosis; regulation of mitochondrial membrane permeability; negative regulation of membrane potential; defense response to virus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.