Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, integral
Cellular Component: nucleoplasm; mitochondrial envelope; mitochondrial outer membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; mitochondrial membrane; dendrite; integral to membrane; nuclear envelope; intracellular; nucleus; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; GTPase binding; protein homodimerization activity; protein heterodimerization activity
Biological Process: cell death; positive regulation of protein complex disassembly; induction of apoptosis by granzyme; apoptosis; positive regulation of apoptosis; chromatin remodeling; neuron apoptosis; positive regulation of programmed cell death; response to hypoxia; autophagic cell death; brown fat cell differentiation; regulation of mitochondrial membrane permeability; DNA fragmentation during apoptosis; mitochondrial fragmentation during apoptosis; negative regulation of membrane potential; defense response to virus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.