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Protein Page:
BNIP3 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BNIP3 Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, integral
Cellular Component: mitochondrial envelope; mitochondrion; endoplasmic reticulum; dendrite; integral to membrane; nuclear envelope; nucleoplasm; mitochondrial outer membrane; membrane; mitochondrial membrane; cytoplasm; intracellular; nucleus; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; GTPase binding; protein homodimerization activity; protein heterodimerization activity
Biological Process: cell death; positive regulation of protein complex disassembly; induction of apoptosis by granzyme; apoptosis; positive regulation of apoptosis; neuron apoptosis; positive regulation of programmed cell death; response to hypoxia; brown fat cell differentiation; autophagic cell death; regulation of mitochondrial membrane permeability; mitochondrial fragmentation during apoptosis; negative regulation of membrane potential; defense response to virus
Reference #:  O55003 (UniProtKB)
Alt. Names/Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B interacting protein 1, NIP3; BCL2/adenovirus E1B interacting protein 3; Bnip3; Nip3; OTTMUSP00000026604
Gene Symbols: Bnip3
Molecular weight: 20,978 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BNIP3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 S12 GEENLQGSWVELHFS
1 0 S19 SWVELHFSNGNGSSV
0 4 S48-p LLDAQHEsGRSSSKS
0 1 S56-p GRSSSKSsHCDsPPR
0 6 S60-p SKSsHCDsPPRsQtP
0 2 S64-p HCDsPPRsQtPQDTN
0 4 T66-p DsPPRsQtPQDTNRA
0 1 I75 QDTNRAEIDsHsFGE
0 2 S77-p TNRAEIDsHsFGEkN
0 14 S79-p RAEIDsHsFGEkNst
0 3 K83-ub DsHsFGEkNstLsEE
0 8 S85-p HsFGEkNstLsEEDy
0 8 T86-p sFGEkNstLsEEDyI
0 28 S88-p GEkNstLsEEDyIER
0 2 Y92-p stLsEEDyIERRREV
0 1 S101-p ERRREVEsILkKNSD
0 1 K104-ub REVEsILkKNSDWIW
0 1 K128 PPKEFLFKHPKRTAT
0 1 S137 PKRTATLSMRNtsVM
0 2 T141-p ATLSMRNtsVMKkGG
0 2 S142-p TLSMRNtsVMKkGGI
0 1 K146-ub RNtsVMKkGGIFSAD
  human

 
S17-p QEESLQGsWVELHFs
S24-p sWVELHFsNNGNGGS
S54-p LLDAQHEsGRSSSKS
S62-p GRSSSKSsHCDsPPR
S66-p SKSsHCDsPPRSQtP
S70 HCDsPPRSQtPQDTN
T72-p DsPPRSQtPQDTNRA
T82-p DTNRASEtDTHsIGE
T84 NRASEtDTHsIGEkN
S86-p ASEtDTHsIGEkNss
K90-ub DTHsIGEkNssQsEE
S92-p HsIGEkNssQsEEDD
S93-p sIGEkNssQsEEDDI
S95-p GEkNssQsEEDDIER
D99 ssQsEEDDIERRKEV
S108-p ERRKEVEsILKKNSD
K111 KEVEsILKKNSDWIW
K135-ub PPKEFLFkHPKRTAT
S144-p PKRTATLsMRNTsVM
T148 ATLsMRNTsVMKKGG
S149-p TLsMRNTsVMKKGGI
K153 RNTsVMKKGGIFSAE
  rat

 
S12 GEENLQGSWVELHFS
S19 SWVELHFSNGNGSSV
S48-p LLDAQHEsGRSSSKS
S56 GRSSSKSSHCDSPPR
S60 SKSSHCDSPPRSQTP
S64 HCDSPPRSQTPQDTN
T66 DSPPRSQTPQDTNRA
I75 QDTNRAEIDTHsFGE
T77 TNRAEIDTHsFGEKN
S79-p RAEIDTHsFGEKNst
K83 DTHsFGEKNstLsEE
S85-p HsFGEKNstLsEEDY
T86-p sFGEKNstLsEEDYI
S88-p GEKNstLsEEDYIER
Y92 stLsEEDYIERRREV
S101 ERRREVESILKKNSD
K104 REVESILKKNSDWIW
K128 PPKEFLFKHPKRTAT
S137 PKRTATLSMRNTSVM
T141 ATLSMRNTSVMKKGG
S142 TLSMRNTSVMKKGGI
K146 RNTSVMKKGGIFSAD
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