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ApoA5
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Interacts with GPIHBP1. Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). Liver and plasma. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
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| Protein type: Secreted, signal peptide; Secreted; Lipid binding protein |
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Cellular Component: extracellular space; chylomicron; extracellular region
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Molecular Function: heparin binding; protein binding; enzyme binding; low-density lipoprotein receptor binding; enzyme activator activity; phospholipid binding; phosphatidylcholine binding; lipid binding
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Biological Process: positive regulation of fatty acid biosynthetic process; organ regeneration; response to hormone stimulus; lipoprotein metabolic process; positive regulation of lipid catabolic process; cellular lipid metabolic process; lipid transport; positive regulation of receptor-mediated endocytosis; cholesterol homeostasis; triacylglycerol metabolic process; tissue regeneration; acylglycerol homeostasis; triacylglycerol catabolic process; positive regulation of lipoprotein lipase activity
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Reference #:
Q6Q788 (UniProtKB)
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| Alt. Names/Synonyms: Apo-AV; ApoA-V; APOA5; APOAV; Apolipoprotein A-V; Apolipoprotein A5; FLJ97995; MGC126836; MGC126838; RAP3; Regeneration-associated protein 3 |
| Gene Symbols: APOA5 |
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Molecular weight: 41,213 Da
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Basal Isoelectric point: 5.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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