Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
APOA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APOA1 Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein; Secreted; Motility/polarity/chemotaxis; Lipid binding protein; Endoplasmic reticulum; Secreted, signal peptide; Cell development/differentiation
Chromosomal Location of Human Ortholog: 11q23-q24
Cellular Component: extracellular space; endoplasmic reticulum lumen; endocytic vesicle; early endosome; plasma membrane; extracellular region; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; enzyme binding; phospholipid transporter activity; lipase inhibitor activity; beta-amyloid binding; cholesterol transporter activity; cholesterol binding; phospholipid binding; high-density lipoprotein binding; apolipoprotein A-I receptor binding; apolipoprotein receptor binding
Biological Process: phototransduction, visible light; blood vessel endothelial cell migration; cellular lipid metabolic process; negative regulation of lipase activity; axon regeneration in the peripheral nervous system; negative regulation of interleukin-1 beta secretion; sequestering of lipid; platelet degranulation; regulation of cholesterol absorption; phospholipid efflux; retinoid metabolic process; transmembrane transport; response to nutrient; phospholipid homeostasis; response to drug; platelet activation; cholesterol metabolic process; regulation of protein amino acid phosphorylation; organ regeneration; cholesterol transport; regulation of Cdc42 protein signal transduction; protein stabilization; negative regulation of heterotypic cell-cell adhesion; protein amino acid oxidation; adrenal gland development; positive regulation of hydrolase activity; lipoprotein metabolic process; cholesterol efflux; positive regulation of transferase activity; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; glucocorticoid metabolic process; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; response to estrogen stimulus; lipoprotein biosynthetic process; peptidyl-methionine modification; endothelial cell proliferation; negative regulation of inflammatory response; phosphatidylcholine biosynthetic process; blood coagulation
Reference #:  P02647 (UniProtKB)
Alt. Names/Synonyms: Apo-AI; ApoA-I; APOA1; Apolipoprotein A-I; Apolipoprotein A-I(1-242); Apolipoprotein A1; MGC117399
Gene Symbols: APOA1
Molecular weight: 30,778 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APOA1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K36 QSPWDRVKDLATVYV
0 1 K47 TVYVDVLKDSGRDYV
0 1 K47 TVYVDVLKDSGRDYV
0 1 K47 TVYVDVLKDSGRDYV
0 1 S55-p DSGRDYVsQFEGsAL
0 1 G59 DYVsQFEGsALGKQL
0 1 S60-p YVsQFEGsALGKQLN
0 1 A61 VsQFEGsALGKQLNL
0 1 S76 KLLDNWDSVTSTFSK
0 1 K120 DLEEVKAKVQPYLDD
0 1 K130-ac PYLDDFQkKWQEEME
0 1 K130 PYLDDFQKKWQEEME
0 1 K130 PYLDDFQKKWQEEME
0 1 K131 YLDDFQkKWQEEMEL
0 1 Q133 DDFQkKWQEEMELYR
0 1 K142 EMELYRQKVEPLRAE
0 1 K157 LQEGARQKLHELQEK
0 1 K157 LQEGARQKLHELQEK
0 1 S166-p HELQEKLsPLGEEMR
0 1 T185-p AHVDALRtHLAPYsD
0 3 S191-p RtHLAPYsDELRQRL
0 2 K206 AARLEALKENGGARL
0 1 Y216-p GGARLAEyHAkAtEH
0 1 K219-ac RLAEyHAkAtEHLST
0 1 T221-p AEyHAkAtEHLSTLs
0 1 T221-ga AEyHAkAtEHLSTLs
0 1 S228-ga tEHLSTLsEKAKPAL
0 1 S252-p VLESFKVsFLSALEE
0 1 E259 sFLSALEEYTkKLNT
0 1 E259 sFLSALEEYTkKLNT
0 1 K262-ac SALEEYTkKLNTQ__
  mouse

 
K35-ub QSQWDKVkDFANVYV
K46-ac NVYVDAVkDSGRDYV
K46-ub NVYVDAVkDSGRDYV
K46-sc NVYVDAVkDSGRDYV
S54 DSGRDYVSQFEsSsL
S58-p DYVSQFEsSsLGQQL
S59 YVSQFEsSsLGQQLN
S60-p VSQFEsSsLGQQLNL
T75-p NLLENWDtLGSTVSQ
K119-ub DLEEVKQkVQPYLDE
K129 PYLDEFQKkWkEDVE
K129-ub PYLDEFQkkWkEDVE
K129-sc PYLDEFQkkWkEDVE
K130-ub YLDEFQkkWkEDVEL
K132-sc DEFQkkWkEDVELYR
K141-ub DVELYRQkVAPLGAE
K156-ub LQESARQkLQELQGR
K156-ac LQESARQkLQELQGR
S165 QELQGRLSPVAEEFR
T184 THVDSLRTQLAPHSE
S190 RTQLAPHSEQMRESL
K205-ub AQRLAELkSNPTLNE
Y213 SNPTLNEYHTRAKTH
R216 TLNEYHTRAKTHLKT
K218 NEYHTRAKTHLKTLG
K218 NEYHTRAKTHLKTLG
G225 KTHLKTLGEKARPAL
- gap
K256-ac QVQSVIDkASETLTA
K256-ub QVQSVIDkASETLTA
E259 SVIDkASETLTAQ__
  rat

 
K35 QSQWDRVKDFATVYV
K46 TVYVDAVKDSGRDYV
K46 TVYVDAVKDSGRDYV
K46 TVYVDAVKDSGRDYV
S54 DSGRDYVSQFESSTL
S58 DYVSQFESSTLGKQL
S59 YVSQFESSTLGKQLN
T60 VSQFESSTLGKQLNL
T75 NLLDNWDTLGSTVGR
K119 DLENVKQKMQPHLDE
E129 PHLDEFQEKWNEEVE
E129 PHLDEFQEKWNEEVE
E129 PHLDEFQEKWNEEVE
K130 HLDEFQEKWNEEVEA
N132 DEFQEKWNEEVEAYR
K141 EVEAYRQKLEPLGTE
K154 TELHKNAKEMQRHLK
K154 TELHKNAKEMQRHLK
K161 KEMQRHLKVVAEEFR
A180 VNADALRAKFGLYSD
S186 RAKFGLYSDQMRENL
K201 AQRLTEIKNHPTLIE
Y209 NHPTLIEYHTKASDH
K212 TLIEYHTKASDHLKT
S214 IEYHTKASDHLKTLG
S214 IEYHTKASDHLKTLG
G221 SDHLKTLGEKAKPAL
- gap
E252 KIMSMIDEAKKKLNA
E252 KIMSMIDEAKKKLNA
K255 SMIDEAKKKLNA___
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.