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Protein Page:
APOA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APOA1 Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Lipid binding protein; Endoplasmic reticulum; Vesicle protein; Cell development/differentiation; Motility/polarity/chemotaxis
Cellular Component: extracellular space; endoplasmic reticulum lumen; endocytic vesicle; early endosome; extracellular region; plasma membrane; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; enzyme binding; phospholipid transporter activity; lipase inhibitor activity; beta-amyloid binding; cholesterol transporter activity; cholesterol binding; phospholipid binding; apolipoprotein A-I receptor binding; high-density lipoprotein binding; apolipoprotein receptor binding
Biological Process: phototransduction, visible light; blood vessel endothelial cell migration; cellular lipid metabolic process; negative regulation of lipase activity; axon regeneration in the peripheral nervous system; sequestering of lipid; negative regulation of interleukin-1 beta secretion; platelet degranulation; regulation of cholesterol absorption; phospholipid efflux; retinoid metabolic process; transmembrane transport; response to nutrient; phospholipid homeostasis; response to drug; platelet activation; cholesterol metabolic process; regulation of protein amino acid phosphorylation; organ regeneration; regulation of Cdc42 protein signal transduction; cholesterol transport; protein amino acid oxidation; negative regulation of heterotypic cell-cell adhesion; protein stabilization; adrenal gland development; positive regulation of hydrolase activity; lipoprotein metabolic process; cholesterol efflux; positive regulation of transferase activity; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; cholesterol homeostasis; reverse cholesterol transport; response to estrogen stimulus; lipoprotein biosynthetic process; endothelial cell proliferation; negative regulation of inflammatory response; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; blood coagulation
Reference #:  P02647 (UniProtKB)
Alt. Names/Synonyms: Apo-AI; ApoA-I; APOA1; Apolipoprotein A-I; Apolipoprotein A-I(1-242); Apolipoprotein A1; MGC117399
Gene Symbols: APOA1
Molecular weight: 30,778 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APOA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K36 QSPWDRVKDLATVYV
0 1 K47 TVYVDVLKDSGRDYV
0 1 K47 TVYVDVLKDSGRDYV
0 1 K47 TVYVDVLKDSGRDYV
0 1 S55-p DSGRDYVsQFEGsAL
0 1 G59 DYVsQFEGsALGKQL
0 1 S60-p YVsQFEGsALGKQLN
0 1 A61 VsQFEGsALGKQLNL
0 1 S76 KLLDNWDSVTSTFSK
0 1 K120 DLEEVKAKVQPYLDD
0 1 K130-ac PYLDDFQkKWQEEME
0 1 K130 PYLDDFQKKWQEEME
0 1 K130 PYLDDFQKKWQEEME
0 1 K131 YLDDFQkKWQEEMEL
0 1 Q133 DDFQkKWQEEMELYR
0 1 K142 EMELYRQKVEPLRAE
0 1 K157 LQEGARQKLHELQEK
0 1 K157 LQEGARQKLHELQEK
0 1 S166-p HELQEKLsPLGEEMR
0 1 T185-p AHVDALRtHLAPYsD
0 3 S191-p RtHLAPYsDELRQRL
0 2 K206 AARLEALKENGGARL
0 1 Y216-p GGARLAEyHAkAtEH
0 1 K219-ac RLAEyHAkAtEHLST
0 1 T221-p AEyHAkAtEHLSTLs
0 1 T221-ga AEyHAkAtEHLSTLs
0 1 S228-ga tEHLSTLsEKAKPAL
0 1 S252-p VLESFKVsFLSALEE
0 1 E259 sFLSALEEYTkKLNT
0 1 E259 sFLSALEEYTkKLNT
0 1 K262-ac SALEEYTkKLNTQ__
  mouse

 
K35-ub QSQWDKVkDFANVYV
K46-ac NVYVDAVkDSGRDYV
K46-ub NVYVDAVkDSGRDYV
K46-sc NVYVDAVkDSGRDYV
S54 DSGRDYVSQFEsSsL
S58-p DYVSQFEsSsLGQQL
S59 YVSQFEsSsLGQQLN
S60-p VSQFEsSsLGQQLNL
T75-p NLLENWDtLGSTVSQ
K119-ub DLEEVKQkVQPYLDE
K129 PYLDEFQKkWkEDVE
K129-ub PYLDEFQkkWkEDVE
K129-sc PYLDEFQkkWkEDVE
K130-ub YLDEFQkkWkEDVEL
K132-sc DEFQkkWkEDVELYR
K141-ub DVELYRQkVAPLGAE
K156-ub LQESARQkLQELQGR
K156-ac LQESARQkLQELQGR
S165 QELQGRLSPVAEEFR
T184 THVDSLRTQLAPHSE
S190 RTQLAPHSEQMRESL
K205-ub AQRLAELkSNPTLNE
Y213 SNPTLNEYHTRAKTH
R216 TLNEYHTRAKTHLKT
K218 NEYHTRAKTHLKTLG
K218 NEYHTRAKTHLKTLG
G225 KTHLKTLGEKARPAL
Q249 MLETLKTQVQSVIDk
K256-ac QVQSVIDkASETLTA
K256-ub QVQSVIDkASETLTA
E259 SVIDkASETLTAQ__
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