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ApoA1
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Motility/polarity/chemotaxis; Transporter; Vesicle protein; Lipid binding protein; Endoplasmic reticulum; Cell development/differentiation; Secreted, signal peptide |
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Cellular Component: extracellular space; endocytic vesicle; endoplasmic reticulum lumen; extracellular region; plasma membrane; cytoplasmic vesicle; secretory granule
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Molecular Function: identical protein binding; protein binding; enzyme binding; cholesterol transporter activity; beta-amyloid binding; cholesterol binding; phospholipid binding; high-density lipoprotein binding; apolipoprotein A-I receptor binding; apolipoprotein receptor binding
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Biological Process: blood vessel endothelial cell migration; cellular lipid metabolic process; sequestering of lipid; negative regulation of interleukin-1 beta secretion; platelet degranulation; regulation of cholesterol absorption; phospholipid efflux; negative regulation of hydrolase activity; transmembrane transport; phospholipid homeostasis; platelet activation; cholesterol metabolic process; regulation of protein amino acid phosphorylation; regulation of Cdc42 protein signal transduction; cholesterol transport; negative regulation of heterotypic cell-cell adhesion; protein amino acid oxidation; protein stabilization; adrenal gland development; positive regulation of hydrolase activity; lipoprotein metabolic process; cholesterol efflux; positive regulation of transferase activity; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; cholesterol homeostasis; reverse cholesterol transport; lipoprotein biosynthetic process; peptidyl-methionine modification; negative regulation of inflammatory response; endothelial cell proliferation; phosphatidylcholine biosynthetic process; lipid metabolic process; blood coagulation
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Reference #:
P02647 (UniProtKB)
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| Alt. Names/Synonyms: Apo-AI; ApoA-I; APOA1; Apolipoprotein A-I; Apolipoprotein A-I(1-242); Apolipoprotein A1; MGC117399 |
| Gene Symbols: APOA1 |
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Molecular weight: 30,778 Da
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Basal Isoelectric point: 5.56
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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