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ARG1 (human)

Overview ARG1 Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.5.3.1; Amino Acid Metabolism - arginine and proline; Hydrolase Cellular Component: extracellular space; neuron projection; cell soma; cytoplasm; cytosol Molecular Function: manganese ion binding; arginase activity Biological Process: response to drug; mammary gland involution; maternal process involved in pregnancy; response to herbicide; liver development; response to amino acid stimulus; response to vitamin A; response to manganese ion; response to selenium ion; response to vitamin E; response to cadmium ion; response to zinc ion; response to methylmercury; arginine catabolic process; positive regulation of endothelial cell proliferation; response to axon injury; collagen biosynthetic process; lung development; urea cycle Reference #:  P05089 (UniProtKB) Alt. Names/Synonyms: ARG1; ARGI1; arginase 1; arginase, liver; Arginase-1; Liver-type arginase; Type I arginase Gene Symbols: ARG1 Molecular weight: 34,735 Da Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ARG1 1WVA - A/B=1-322 (human) 1WVB - A/B=1-322 (human) 2AEB - A/B=1-322 (human) 2PHA - A/B=1-322 (human) 2PHO - A/B=1-322 (human) 2PLL - A/B=1-322 (human) 2ZAV - A/B=1-322 (human) 3DJ8 - A/B=1-322 (human) 3E6K - A/B=1-322 (human) 3E6V - A/B=1-322 (human) 3F80 - A/B=1-322 (human) 3GMZ - A/B=1-322 (human) 3GN0 - A/B=1-322 (human) 3KV2 - A/B=1-322 (human) 3LP4 - A/B=1-322 (human) 3LP7 - A/B=1-322 (human) 3MFV - A/B=1-322 (human) 3MFW - A/B=1-322 (human) 3MJL - A/B=1-322 (human) 3SJT - A/B=1-322 (human) 3SKK - A/B=1-322 (human) 3TF3 - A/B=1-322 (human) 3TH7 - A/B=1-322 (human) 3THE - A/B=1-322 (human) 3THH - A/B=1-322 (human) 3THJ - A/B=1-322 (human) 4FCI - A/B=1-322 (human) 4FCK - A/B=1-322 (human) 4GSM - A/B=1-322 (human) 4GSV - A/B=1-322 (human) 4GSZ - A/B=1-322 (human) 4GWC - A/B=1-322 (human) 4GWD - A/B=1-322 (human) 4HWW - A/B=5-318 (human) 4HXQ - A/B=5-318 (human) 4IE1 - A/B=5-318 (human) 1D3V - A/B=1-323 (rat) 1HQ5 - A/B=1-323 (rat) 1HQF - A/C/B=1-323 (rat) 1HQG - A/C/B=1-323 (rat) 1HQH - A/C/B=1-323 (rat) 1HQX - A/C/B=1-323 (rat) 1P8M - A/C/B=1-314 (rat) 1P8N - A/C/B=6-319 (rat) 1P8O - A/C/B=6-319 (rat) 1P8P - A/C/B=6-319 (rat) 1P8Q - A/C/B=6-319 (rat) 1P8R - A/B=6-313 (rat) 1P8S - A/C/B=6-319 (rat) 1R1O - A/C/B=1-323 (rat) 1RLA - A/C/B=1-323 (rat) 1T4P - A/C/B=6-319 (rat) 1T4R - A/C/B=6-319 (rat) 1T4S - A/C/B=6-319 (rat) 1T4T - A/C/B=6-319 (rat) 1T5F - A/C/B=6-319 (rat) 1T5G - A/C/B=6-319 (rat) 1TA1 - A/C/B=6-319 (rat) 1TBH - A/C/B=6-319 (rat) 1TBJ - A/C/B=6-319 (rat) 1TBL - A/C/B=6-319 (rat) 1ZPE - A/C/B=6-319 (rat) 1ZPG - A/C/B=6-319 (rat) 2RLA - A/C/B=1-323 (rat) 3E8Q - A/C/B=1-323 (rat) 3E8Z - A/C/B=1-323 (rat) 3E9B - A/C/B=1-323 (rat) 3RLA - A/C/B=1-323 (rat) 4RLA - A/C/B=1-323 (rat) 5RLA - A/C/B=1-323 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1  |  ENZYME  |  Phospho3D  |  DISEASE 207800 608313  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		R6	__MSAKSRTIGIIGA
0	2		T7	_MSAKSRTIGIIGAP
0	1		S16-p	GIIGAPFsKGQPRGG
0	2		K17	IIGAPFsKGQPRGGV
0	1		K17	IIGAPFsKGQPRGGV
0	2		E26	QPRGGVEEGPtVLRK
0	3		E26	QPRGGVEEGPtVLRK
0	1		T29-p	GGVEEGPtVLRKAGL
0	1		K39	RKAGLLEKLKEQECD
0	2		K41	AGLLEKLKEQECDVK
0	1		K41	AGLLEKLKEQECDVK
0	84		Y50-p	QECDVKDyGDLPFAD
0	1		K68	DSPFQIVKNPRsVGK
0	3		S72-p	QIVKNPRsVGKASEQ
0	1		K75	KNPRsVGKASEQLAG
0	1		K89	GKVAEVKKNGRIsLV
0	1		K89	GKVAEVKKNGRIsLV
0	1		S94-p	VKKNGRIsLVLGGDH
0	1		S102-p	LVLGGDHsLAIGsIs
0	1		S107-p	DHsLAIGsIsGHARV
0	1		S109-p	sLAIGsIsGHARVHP
0	1		K153	SFLLKELKGKIPDVP
0	1		K155	LLKELKGKIPDVPGF
0	1		K155	LLKELKGKIPDVPGF
0	12		S163-p	IPDVPGFsWVtPCIS
0	1		T166-p	VPGFsWVtPCISAKD
0	2		K191-a	PGEHYILkTLGIKYF
0	1		K191	PGEHYILKTLGIKYF
0	1		K196	ILkTLGIKYFSMTEV
0	2		R205	FSMTEVDRLGIGKVM
0	1		S217-p	KVMEETLsYLLGRKK
0	2		S230	KKRPIHLSFDVDGLD
0	1		T241	DGLDPSFTPATGTPV
0	2		Y265-p	LYITEEIyKTGLLSG
0	5		S281	DIMEVNPSLGKTPEE
0	1		K284	EVNPSLGKTPEEVTR
0	1		K284	EVNPSLGKTPEEVTR
0	1		K313	LAREGNHKPIDYLNP
0	2		N319	HKPIDYLNPPK____

	mouse
K6-u	__MSSKPksLEIIGA
S7-p	_MSSKPksLEIIGAP
S16	EIIGAPFSkGQPRGG
K17-a	IIGAPFSkGQPRGGV
K17-u	IIGAPFSkGQPRGGV
K26-u	QPRGGVEkGPAALRK
K26-a	QPRGGVEkGPAALRK
A29	GGVEkGPAALRKAGL
K39-u	RKAGLLEkLkETEYD
K41-a	AGLLEkLkETEYDVR
K41-u	AGLLEkLkETEYDVR
H50	TEYDVRDHGDLAFVD
K68-u	DSSFQIVkNPRsVGk
S72-p	QIVkNPRsVGkANEE
K75-u	kNPRsVGkANEELAG
K89-a	GVVAEVQkNGRVSVV
K89-u	GVVAEVQkNGRVSVV
S94	VQkNGRVSVVLGGDH
S102	VVLGGDHSLAVGSIS
S107	DHSLAVGSISGHARV
S109	SLAVGSISGHARVHP
K153-u	SFLLKELkGkFPDVP
K155-a	LLKELkGkFPDVPGF
K155-u	LLKELkGkFPDVPGF
S163-p	FPDVPGFsWVTPCIS
T166	VPGFsWVTPCISAKD
K191-a	PGEHYIIkTLGIkYF
K191-u	PGEHYIIkTLGIkYF
K196-u	IIkTLGIkYFSMTEV
K205-u	FSMTEVDkLGIGKVM
S217-p	KVMEETFsYLLGRKK
S230-p	KKRPIHLsFDVDGLD
T241-p	DGLDPAFtPATGTPV
Y265-p	LYITEEIyKTGLLSG
T281-p	DIMEVNPtLGkTAEE
K284-a	EVNPtLGkTAEEVKS
K284-u	EVNPtLGkTAEEVKS
K313-u	TQREGNHkPGTDYLk
K320-a	kPGTDYLkPPK____

	rat
K6	__MSSKPKPIEIIGA
P7	_MSSKPKPIEIIGAP
S16	EIIGAPFSKGQPRGG
K17	IIGAPFSKGQPRGGV
K17	IIGAPFSKGQPRGGV
K26	QPRGGVEKGPAALRK
K26	QPRGGVEKGPAALRK
A29	GGVEKGPAALRKAGL
K39	RKAGLVEKLKETEYN
K41	AGLVEKLKETEYNVR
K41	AGLVEKLKETEYNVR
H50	TEYNVRDHGDLAFVD
K68	DSPFQIVKNPRSVGK
S72	QIVKNPRSVGKANEQ
K75	KNPRSVGKANEQLAA
K89	AVVAETQKNGTISVV
K89	AVVAETQKNGTISVV
S94	TQKNGTISVVLGGDH
S102	VVLGGDHSMAIGSIS
S107	DHSMAIGSISGHARV
S109	SMAIGSISGHARVHP
K153	AFLLKELKGKFPDVP
K155	LLKELKGKFPDVPGF
K155	LLKELKGKFPDVPGF
S163-p	FPDVPGFsWVTPCIS
T166	VPGFsWVTPCISAKD
K191	PGEHYIIKTLGIKYF
K191	PGEHYIIKTLGIKYF
K196	IIKTLGIKYFSMTEV
K205	FSMTEVDKLGIGKVM
S217	KVMEETFSYLLGRKK
S230	KKRPIHLSFDVDGLD
T241	DGLDPVFTPATGTPV
Y265	LYITEEIYKTGLLSG
T281-p	DIMEVNPtLGKTPEE
K284	EVNPtLGKTPEEVTR
K284	EVNPtLGKTPEEVTR
K313	TKREGNHKPETDYLK
K320	KPETDYLKPPK____

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