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Protein Page:
ARG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARG1 Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.3.1; Hydrolase; Amino Acid Metabolism - arginine and proline
Cellular Component: extracellular space; neuron projection; cell soma; cytoplasm; nucleus; cytosol
Molecular Function: manganese ion binding; arginase activity
Biological Process: response to drug; mammary gland involution; maternal process involved in pregnancy; response to herbicide; liver development; response to amino acid stimulus; response to vitamin A; response to manganese ion; response to selenium ion; response to vitamin E; response to cadmium ion; response to zinc ion; response to methylmercury; arginine catabolic process; positive regulation of endothelial cell proliferation; response to axon injury; collagen biosynthetic process; response to amine stimulus; lung development; urea cycle
Reference #:  P05089 (UniProtKB)
Alt. Names/Synonyms: ARG1; ARGI1; arginase 1; arginase, liver; Arginase-1; Liver-type arginase; Type I arginase
Gene Symbols: ARG1
Molecular weight: 34,735 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARG1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R6 __MSAKSRTIGIIGA
0 1 R6 __MSAKSRTIGIIGA
0 3 T7 _MSAKSRTIGIIGAP
0 2 S16-p GIIGAPFsKGQPRGG
0 3 K17 IIGAPFsKGQPRGGV
0 1 K17 IIGAPFsKGQPRGGV
0 1 K17 IIGAPFsKGQPRGGV
0 2 E26 QPRGGVEEGPtVLRK
0 4 E26 QPRGGVEEGPtVLRK
0 1 T29-p GGVEEGPtVLRKAGL
0 1 K39 RKAGLLEKLKEQECD
0 1 K39 RKAGLLEKLKEQECD
0 3 K41 AGLLEKLKEQECDVK
0 1 K41 AGLLEKLKEQECDVK
0 1 K41 AGLLEKLKEQECDVK
0 84 Y50-p QECDVKDyGDLPFAD
0 1 S62-p FADIPNDsPFQIVKN
0 1 K68 DsPFQIVKNPRsVGK
0 1 K68 DsPFQIVKNPRsVGK
0 3 S72-p QIVKNPRsVGKASEQ
0 1 K75 KNPRsVGKASEQLAG
0 1 K75 KNPRsVGKASEQLAG
0 2 K89 GKVAEVKKNGRIsLV
0 1 K89 GKVAEVKKNGRIsLV
0 1 S94-p VKKNGRIsLVLGGDH
0 1 S102-p LVLGGDHsLAIGsIs
0 1 S107-p DHsLAIGsIsGHARV
0 1 S109-p sLAIGsIsGHARVHP
0 1 K153 SFLLKELKGKIPDVP
0 1 K155 LLKELKGKIPDVPGF
0 1 K155 LLKELKGKIPDVPGF
0 14 S163-p IPDVPGFsWVtPCIs
0 2 T166-p VPGFsWVtPCIsAKD
0 1 S170-p sWVtPCIsAKDIVYI
0 3 K191-ac PGEHYILkTLGIKYF
0 1 K191 PGEHYILKTLGIKYF
0 1 K191 PGEHYILKTLGIKYF
0 1 K196 ILkTLGIKYFSMTEV
0 1 K196 ILkTLGIKYFSMTEV
0 1 R205 FSMTEVDRLGIGKVM
0 2 R205 FSMTEVDRLGIGKVM
0 3 S217-p KVMEETLsYLLGRKK
0 2 S230 KKRPIHLSFDVDGLD
0 1 T241 DGLDPSFTPATGTPV
0 2 Y265-p LYITEEIyKTGLLSG
0 6 S281 DIMEVNPSLGKTPEE
0 2 K284 EVNPSLGKTPEEVTR
0 1 K284 EVNPSLGKTPEEVTR
0 1 K313 LAREGNHKPIDYLNP
0 3 N319 HKPIDYLNPPK____
  mouse

 
K6-ac __MSSKPksLEIIGA
K6-ub __MSSKPksLEIIGA
S7-p _MSSKPksLEIIGAP
S16 EIIGAPFSkGQPRGG
K17-ac IIGAPFSkGQPRGGV
K17-ub IIGAPFSkGQPRGGV
K17-sc IIGAPFSkGQPRGGV
K26-ub QPRGGVEkGPAALRK
K26-ac QPRGGVEkGPAALRK
A29 GGVEkGPAALRKAGL
K39-ac RKAGLLEkLkETEYD
K39-ub RKAGLLEkLkETEYD
K41-ac AGLLEkLkETEYDVR
K41-ub AGLLEkLkETEYDVR
K41-sc AGLLEkLkETEYDVR
H50 TEYDVRDHGDLAFVD
S62 FVDVPNDSSFQIVkN
K68-ac DSSFQIVkNPRsVGk
K68-ub DSSFQIVkNPRsVGk
S72-p QIVkNPRsVGkANEE
K75-ub kNPRsVGkANEELAG
K75-sc kNPRsVGkANEELAG
K89-ac GVVAEVQkNGRVSVV
K89-ub GVVAEVQkNGRVSVV
S94 VQkNGRVSVVLGGDH
S102 VVLGGDHSLAVGSIS
S107 DHSLAVGSISGHARV
S109 SLAVGSISGHARVHP
K153-ub SFLLKELkGkFPDVP
K155-ac LLKELkGkFPDVPGF
K155-ub LLKELkGkFPDVPGF
S163-p FPDVPGFsWVTPCIS
T166 VPGFsWVTPCISAKD
S170 sWVTPCISAKDIVYI
K191-ac PGEHYIIkTLGIkYF
K191-ub PGEHYIIkTLGIkYF
K191-sc PGEHYIIkTLGIkYF
K196-ac IIkTLGIkYFSMTEV
K196-ub IIkTLGIkYFSMTEV
K205-ac FSMTEVDkLGIGKVM
K205-ub FSMTEVDkLGIGKVM
S217-p KVMEETFsYLLGRKK
S230-p KKRPIHLsFDVDGLD
T241-p DGLDPAFtPATGTPV
Y265-p LYITEEIyKTGLLSG
T281-p DIMEVNPtLGkTAEE
K284-ac EVNPtLGkTAEEVKS
K284-ub EVNPtLGkTAEEVKS
K313-ub TQREGNHkPGTDYLk
K320-ac kPGTDYLkPPK____
  rat

 
K6 __MSSKPKPIEIIGA
K6 __MSSKPKPIEIIGA
P7 _MSSKPKPIEIIGAP
S16 EIIGAPFSKGQPRGG
K17 IIGAPFSKGQPRGGV
K17 IIGAPFSKGQPRGGV
K17 IIGAPFSKGQPRGGV
K26 QPRGGVEKGPAALRK
K26 QPRGGVEKGPAALRK
A29 GGVEKGPAALRKAGL
K39 RKAGLVEKLKETEYN
K39 RKAGLVEKLKETEYN
K41 AGLVEKLKETEYNVR
K41 AGLVEKLKETEYNVR
K41 AGLVEKLKETEYNVR
H50 TEYNVRDHGDLAFVD
S62-p FVDVPNDsPFQIVKN
K68 DsPFQIVKNPRSVGK
K68 DsPFQIVKNPRSVGK
S72 QIVKNPRSVGKANEQ
K75 KNPRSVGKANEQLAA
K75 KNPRSVGKANEQLAA
K89 AVVAETQKNGTISVV
K89 AVVAETQKNGTISVV
S94 TQKNGTISVVLGGDH
S102 VVLGGDHSMAIGSIS
S107 DHSMAIGSISGHARV
S109 SMAIGSISGHARVHP
K153 AFLLKELKGKFPDVP
K155 LLKELKGKFPDVPGF
K155 LLKELKGKFPDVPGF
S163-p FPDVPGFsWVTPCIS
T166 VPGFsWVTPCISAKD
S170 sWVTPCISAKDIVYI
K191 PGEHYIIKTLGIKYF
K191 PGEHYIIKTLGIKYF
K191 PGEHYIIKTLGIKYF
K196 IIKTLGIKYFSMTEV
K196 IIKTLGIKYFSMTEV
K205 FSMTEVDKLGIGKVM
K205 FSMTEVDKLGIGKVM
S217 KVMEETFSYLLGRKK
S230 KKRPIHLSFDVDGLD
T241 DGLDPVFTPATGTPV
Y265 LYITEEIYKTGLLSG
T281-p DIMEVNPtLGKTPEE
K284 EVNPtLGKTPEEVTR
K284 EVNPtLGKTPEEVTR
K313 TKREGNHKPETDYLK
K320 KPETDYLKPPK____
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