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GluR1 (human)

Overview GluR1 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation. Note: This description may include information from UniProtKB. Protein type: Channel, calcium; Membrane protein, integral; Channel, ligand-gated Cellular Component: postsynaptic membrane; endoplasmic reticulum membrane; cell surface; cell soma; dendrite; postsynaptic density; dendritic spine; plasma membrane; cell junction Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; glutamate receptor activity; PDZ domain binding Biological Process: synaptic transmission; long-term memory; receptor internalization; signal transduction Reference #:  P42261 (UniProtKB) Alt. Names/Synonyms: AMPA 1; AMPA-selective glutamate receptor 1; GLUH1; GluR-1; GluR-A; GluR-K1; GLUR1; GLURA; Glutamate receptor 1; Glutamate receptor ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA 1; GRIA1; HBGR1; MGC133252 Gene Symbols: GRIA1 Molecular weight: 101,506 Da Basal Isoelectric point: 7.79  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GluR1 3SAJ - A/D/C/B=22-392 (rat)

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	Sites Implicated In
activation: S849‑p intracellular localization: C829‑h, S834‑p, S836‑p molecular association, regulation: C829‑h, S834‑p, S836‑p phosphorylation: C829‑h

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y226-p	LEKNGIGyHyILANL
0	2		Y228-p	KNGIGyHyILANLGF
0	1		K265-a	YTDTIPAkIMQQWKN
0	1		Y294-p	KYTSALTyDGVKVMA
0	1		T350-p	QVRFEGLtGNVQFNE
0	1		K358	GNVQFNEKGRRTNYT
0	1		T393	DKFVPAATDAQAGGD
0	1		Y438	GNDRYEGYCVELAAE
1	0		S567-p	FSPYEWHsEEFEEGR
0	1		T577	FEEGRDQTTSDQSNE
0	1		T578	EEGRDQTTSDQSNEF
0	1		S579	EGRDQTTSDQSNEFG
0	1		S582	DQTTSDQSNEFGIFN
1	0		S645	LTVERMVSPIESAED
1	0		S710	GMIRVRKSKGKYAYL
0	1		S754-p	GIATPKGsALRNPVN
1	0		C829-h	LVALIEFcYKsRsEs
0	1		S832-p	LIEFcYKsRsEsKRM
1	0		S834-p	EFcYKsRsEsKRMKG
6	0		S836-p	cYKsRsEsKRMKGFC
61	5		S849-p	FCLIPQQsINEAIRT
0	1		R855	QsINEAIRTSTLPRN
1	0		T856	sINEAIRTSTLPRNs
1	0		S857	INEAIRTSTLPRNsG
2	0		T858	NEAIRTSTLPRNsGA
62	0		S863-p	TSTLPRNsGAGASSG
0	1		S880-p	GENGRVVsHDFPKSM

	mouse
Y226-p	LEKNGIGyHyILANL
Y228-p	KNGIGyHyILANLGF
R265	YTDTIPARIMQQWRT
Y294	KYTSALTYDGVKVMA
T350	QVRFEGLTGNVQFNE
K358-u	GNVQFNEkGRRTNYT
T393-p	DKFVPAAtDAQAGGD
Y438-p	GNDRYEGyCVELAAE
S567	FSPYEWHSEEFEEGR
T577-p	FEEGRDQttsDQsNE
T578-p	EEGRDQttsDQsNEF
S579-p	EGRDQttsDQsNEFG
S582-p	DQttsDQsNEFGIFN
S645	LTVERMVSPIESAED
S710	GMIRVRKSKGKYAYL
S754	GIATPKGSALRGPVN
C829	LVALIEFCYKSRSEs
S832	LIEFCYKSRSEsKRM
S834	EFCYKSRSEsKRMKG
S836-p	CYKSRSEsKRMKGFC
S849-p	FCLIPQQsINEAIRt
R855	QsINEAIRtstLPRN
T856-p	sINEAIRtstLPRNs
S857-p	INEAIRtstLPRNsG
T858-p	NEAIRtstLPRNsGA
S863-p	tstLPRNsGAGASGG
S881-p	GENGRVVsQDFPKSM

	rat
Y226	LEKNGIGYHYILANL
Y228	KNGIGYHYILANLGF
R265	YTDTIPARIMQQWRT
Y294	KYTSALTYDGVKVMA
T350	QVRFEGLTGNVQFNE
K358	GNVQFNEKGRRTNYT
T393	DKFVPAATDAQAGGD
Y438	GNDRYEGYCVELAAE
S567-p	FSPYEWHsEEFEEGR
T577	FEEGRDQTTSDQSNE
T578	EEGRDQTTSDQSNEF
S579	EGRDQTTSDQSNEFG
S582	DQTTSDQSNEFGIFN
S645-p	LTVERMVsPIESAED
S710-p	GMIRVRKsKGKYAYL
S754	GIATPKGSALRNPVN
C829	LVALIEFCYKSRSEs
S832	LIEFCYKSRSEsKRM
S834	EFCYKSRSEsKRMKG
S836-p	CYKSRSEsKRMKGFC
S849-p	FCLIPQQsINEAIrT
R855-m1	QsINEAIrTSTLPRN
T856	sINEAIrTSTLPRNs
S857	INEAIrTSTLPRNsG
T858	NEAIrTSTLPRNsGA
S863-p	TSTLPRNsGAGASGG
S881	GENGRVVSQDFPKSM

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