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Protein Page:
GluR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GluR1 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: postsynaptic membrane; synaptic vesicle; endoplasmic reticulum membrane; cell surface; cell soma; postsynaptic density; dendrite; plasma membrane; dendritic spine; cell junction
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; glutamate receptor activity; PDZ domain binding
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; long-term memory; ionotropic glutamate receptor signaling pathway; receptor internalization; signal transduction
Reference #:  P42261 (UniProtKB)
Alt. Names/Synonyms: AMPA 1; AMPA-selective glutamate receptor 1; GLUH1; GluR-1; GluR-A; GluR-K1; GLUR1; GLURA; Glutamate receptor 1; Glutamate receptor ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA 1; GRIA1; HBGR1; MGC133252
Gene Symbols: GRIA1
Molecular weight: 101,506 Da
Basal Isoelectric point: 7.79  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GluR1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S849‑p
intracellular localization: C829‑pa, S834‑p, S836‑p
molecular association, regulation: C829‑pa, S834‑p, S836‑p
phosphorylation: C829‑pa

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y226-p LEKNGIGyHyILANL
0 2 Y228-p KNGIGyHyILANLGF
0 1 K265-ac YTDTIPAkIMQQWKN
0 1 Y294-p KYTSALTyDGVKVMA
0 1 T350-p QVRFEGLtGNVQFNE
0 1 K358 GNVQFNEKGRRTNYT
0 1 T393 DKFVPAATDAQAGGD
0 1 Y438 GNDRYEGYCVELAAE
1 0 S567-p FSPYEWHsEEFEEGR
0 1 T577 FEEGRDQTTSDQSNE
0 1 T578 EEGRDQTTSDQSNEF
0 1 S579 EGRDQTTSDQSNEFG
0 1 S582 DQTTSDQSNEFGIFN
1 0 S645 LTVERMVSPIESAED
1 0 S710 GMIRVRKSKGKYAYL
0 1 S754-p GIATPKGsALRNPVN
1 0 C829-pa LVALIEFcYKsRsEs
0 1 S832-p LIEFcYKsRsEsKRM
1 0 S834-p EFcYKsRsEsKRMKG
6 0 S836-p cYKsRsEsKRMKGFC
65 5 S849-p FCLIPQQsINEAIRT
0 1 R855 QsINEAIRTSTLPRN
1 0 T856 sINEAIRTSTLPRNs
1 0 S857 INEAIRTSTLPRNsG
3 0 T858 NEAIRTSTLPRNsGA
70 0 S863-p TSTLPRNsGAGASSG
0 1 S880 GENGRVVSHDFPKSM
8084 : Phospho-AMPA Receptor (GluR 1) (Ser845) (D10G5) Rabbit mAb
  mouse

 
Y226-p LEKNGIGyHyILANL
Y228-p KNGIGyHyILANLGF
R265 YTDTIPARIMQQWRT
Y294 KYTSALTYDGVKVMA
T350 QVRFEGLTGNVQFNE
K358-ub GNVQFNEkGRRTNYT
T393-p DKFVPAAtDAQAGGD
Y438-p GNDRYEGyCVELAAE
S567 FSPYEWHSEEFEEGR
T577-p FEEGRDQttsDQsNE
T578-p EEGRDQttsDQsNEF
S579-p EGRDQttsDQsNEFG
S582-p DQttsDQsNEFGIFN
S645 LTVERMVSPIESAED
S710 GMIRVRKSKGKYAYL
S754 GIATPKGSALRGPVN
C829 LVALIEFCYKSRSEs
S832 LIEFCYKSRSEsKRM
S834 EFCYKSRSEsKRMKG
S836-p CYKSRSEsKRMKGFC
S849-p FCLIPQQsINEAIRt
R855 QsINEAIRtstLPRN
T856-p sINEAIRtstLPRNs
S857-p INEAIRtstLPRNsG
T858-p NEAIRtstLPRNsGA
S863-p tstLPRNsGAGASGG
S881-p GENGRVVsQDFPKSM
8084 : Phospho-AMPA Receptor (GluR 1) (Ser845) (D10G5) Rabbit mAb
  rat

 
Y226 LEKNGIGYHYILANL
Y228 KNGIGYHYILANLGF
R265 YTDTIPARIMQQWRT
Y294 KYTSALTYDGVKVMA
T350 QVRFEGLTGNVQFNE
K358 GNVQFNEKGRRTNYT
T393 DKFVPAATDAQAGGD
Y438 GNDRYEGYCVELAAE
S567-p FSPYEWHsEEFEEGR
T577 FEEGRDQTTSDQSNE
T578 EEGRDQTTSDQSNEF
S579 EGRDQTTSDQSNEFG
S582 DQTTSDQSNEFGIFN
S645-p LTVERMVsPIESAED
S710-p GMIRVRKsKGKYAYL
S754 GIATPKGSALRNPVN
C829 LVALIEFCYKSRSEs
S832 LIEFCYKSRSEsKRM
S834 EFCYKSRSEsKRMKG
S836-p CYKSRSEsKRMKGFC
S849-p FCLIPQQsINEAIrT
R855-m1 QsINEAIrTSTLPRN
T856 sINEAIrTSTLPRNs
S857 INEAIrTSTLPRNsG
T858 NEAIrTSTLPRNsGA
S863-p TSTLPRNsGAGASGG
S881 GENGRVVSQDFPKSM
8084 : Phospho-AMPA Receptor (GluR 1) (Ser845) (D10G5) Rabbit mAb
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