a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Translation; Other group; PEK family; GCN2 subfamily
Chromosomal Location of Human Ortholog: 15q15.1
Molecular Function: protein serine/threonine kinase activity; protein homodimerization activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding
Biological Process: regulation of translation initiation in response to stress; unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.