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GCN2 (human)

Overview GCN2 a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Translation; Protein kinase, Other; EC 2.7.11.1; Other group; PEK family; GCN2 subfamily Cellular Component: intracellular Molecular Function: protein serine/threonine kinase activity; protein homodimerization activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding; tRNA binding Biological Process: regulation of translation initiation in response to stress; unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation Reference #:  Q9P2K8 (UniProtKB) Alt. Names/Synonyms: E2AK4; EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; KIAA1338 Gene Symbols: EIF2AK4 Molecular weight: 186,911 Da Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states CST Pathways:  Translation: eIF2 Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GCN2 1UKX - A=17-139 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S230-p	AAILHGGsPDFVGNG
0	1		Y253-p	RSRRERQysVCNSED
0	15		S254-p	SRRERQysVCNSEDs
0	1		S261-p	sVCNSEDsPGSCEIL
0	1		Y269-p	PGSCEILyFNMGSPD
0	1		T438	VLVDAEGTVKITDYS
0	2		Y500-p	QGQECGEyPVTIPSD
0	3		S551-p	KMPLVEQsPEDsEGQ
0	4		S555-p	VEQsPEDsEGQDyVE
0	3		Y560-p	EDsEGQDyVETVIPS
0	1		S572-p	IPSNRLPsAAFFSET
0	1		K606-a	GAFGAVIkVQNKLDG
0	5		T667-p	ERPAGPGtPPPDSGP
1	0		T899	SDPSGHLTGMVGTAL
0	1		S928-p	NQKVDLFsLGIIFFE
0	1		T991-p	HDPAKRPtATELLKS
0	1		T1085-p	HGAVQLCtPLLLPRN
0	1		K1259-a	NSLCRLYkFIEQKGD

	mouse
S230	AAILHGGSPDFVGNG
Y253	RSRRERQYsVCSGEP
S254-p	SRRERQYsVCSGEPS
S261	sVCSGEPSPGSCDIL
H269	PGSCDILHFSVGSPD
T437-p	VLVDAEGtVKITDYS
Y499	QGQECGEYPVTIPSD
S550	KLPLVEQSPEDSGGQ
S554	VEQSPEDSGGQDyIE
Y559-p	EDSGGQDyIETVIPS
S571	IPSNQLPSAAFFSET
K605	GAFGAVIKVQNKLDG
T666	ERPAVPGTPPPDCTP
T898-p	SDPSGHLtGMVGTAL
S927	NQKVDLFSLGIIFFE
T990	HDPAKRPTAMELLKS
T1084	HGAVQLCTPLLLPRN
K1258	NSLCRLYKFIEQKGD

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