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Protein Page:
TMPO iso6 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TMPO iso6 a single-pass type II membrane protein. Tightly associated with the nuclear lamina. Binds DNA and involved in DNA replication and chromatin remodeling, May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with HAP95. Associated with dilated cardiomyopathy; upregulated in medulloblastoma. Used as a pharmaceutical to treat primary and secondary immune deficiencies, autoimmunity, infections and cancer. Available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; DNA binding protein
Cellular Component: integral to membrane; nuclear inner membrane; nuclear envelope; chromatin; nucleus
Molecular Function: protein binding; DNA binding; lamin binding
Biological Process: regulation of transcription, DNA-dependent
Reference #:  P42166 (UniProtKB)
Alt. Names/Synonyms: CMD1T; lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoform alpha; LAP2; LAP2A; LEM domain containing 4; LEMD4; MGC61508; PRO0868; Splenin; Thymopentin; Thymopoietin; Thymopoietin isoform alpha; thymopoietin-related peptide; Thymopoietin-related peptide isoform alpha; TMPO; TP; TP alpha; TP beta/gamma; TP5; TPRP isoform alpha
Gene Symbols: TMPO
Molecular weight: 75,492 Da
Basal Isoelectric point: 7.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TMPO iso6
Protein Structure Not Found.


Scansite  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 2 S9-p PEFLEDPsVLtKDKL
0 3 T12-p LEDPsVLtKDKLKsE
0 1 S18-p LtKDKLKsELVANNV
0 1 T57-p RPPLPAGtNskGPPD
0 5 S59-p PLPAGtNskGPPDFs
0 1 K60-a LPAGtNskGPPDFss
0 1 K60-u LPAGtNskGPPDFss
0 68 S66-p skGPPDFssDEEREP
0 66 S67-p kGPPDFssDEEREPt
0 2 R71 DFssDEEREPtPVLG
0 82 T74-p sDEEREPtPVLGsGA
0 6 S79-p EPtPVLGsGAAAAGR
0 1 A83 VLGsGAAAAGRsRAA
0 25 R86 sGAAAAGRsRAAVGR
0 1 R86 sGAAAAGRsRAAVGR
0 1 S87-p GAAAAGRsRAAVGRK
0 16 R88 AAAAGRsRAAVGRKA
0 1 R88 AAAAGRsRAAVGRKA
0 12 R93 RsRAAVGRKAtKKtD
0 1 T96-p AAVGRKAtKKtDKPR
0 1 T99-p GRKAtKKtDKPRQED
0 1 K107-u DKPRQEDkDDLDVTE
0 4 K126-u DLLDQLVkyGVNPGP
0 4 Y127-p LLDQLVkyGVNPGPI
0 12 T137-p NPGPIVGtTRKLYEK
0 19 T154-p LKLREQGtEsRsstP
0 34 S156-p LREQGtEsRsstPLP
0 27 S158-p EQGtEsRsstPLPtI
0 30 S159-p QGtEsRsstPLPtIs
0 77 T160-p GtEsRsstPLPtIss
0 15 T164-p RsstPLPtIsssAEN
0 8 S166-p stPLPtIsssAENTR
0 6 S167-p tPLPtIsssAENTRQ
0 11 S168-p PLPtIsssAENTRQN
0 7 S177-p ENTRQNGsNDsDRys
0 16 S180-p RQNGsNDsDRysDNE
0 11 Y183-p GsNDsDRysDNEEDs
0 23 S184-p sNDsDRysDNEEDsK
0 2 S190-p ysDNEEDsKIELKLE
0 1 K207-a EPLKGRAktPVtLkQ
0 41 T208-p PLKGRAktPVtLkQR
0 10 T211-p GRAktPVtLkQRRVE
0 7 K213-u AktPVtLkQRRVEHN
0 1 S222-p RRVEHNQsysQAGIT
0 27 Y223-p RVEHNQsysQAGITE
0 32 S224-p VEHNQsysQAGITET
0 1 T229 sysQAGITETEWTSG
0 2 T247-p GGPLQALtREstRGs
0 1 S250-p LQALtREstRGsRRt
0 1 T251-p QALtREstRGsRRtP
0 22 S254-p tREstRGsRRtPRKR
0 9 T257-p stRGsRRtPRKRVEt
0 55 T264-p tPRKRVEtsEHFRID
0 5 S265-p PRKRVEtsEHFRIDG
0 2 S276-p RIDGPVIsEStPIAE
0 8 T279-p GPVIsEStPIAETIM
0 2 M286 tPIAETIMAssNEsL
0 1 S288-p IAETIMAssNEsLVV
0 4 S289-p AETIMAssNEsLVVN
0 3 S292-p IMAssNEsLVVNRVt
0 9 T299-p sLVVNRVtGNFkHAs
0 6 K303-u NRVtGNFkHAsPILP
0 16 S306-p tGNFkHAsPILPItE
0 1 P307 GNFkHAsPILPItEF
0 1 T312-p AsPILPItEFsDIPR
0 4 S315-p ILPItEFsDIPRRAP
0 2 K323-u DIPRRAPkkPLTRAE
0 2 K324-u IPRRAPkkPLTRAEV
0 2 K334-a TRAEVGEkTEERRVE
0 32 K334-u TRAEVGEkTEERRVE
0 23 K346-u RVERDILkEMFPyEA
0 63 Y351-p ILkEMFPyEAstPtG
0 11 S354-p EMFPyEAstPtGIsA
0 37 T355-p MFPyEAstPtGIsAs
0 9 T357-p PyEAstPtGIsAsCR
0 3 S360-p AstPtGIsAsCRRPI
0 22 S362-p tPtGIsAsCRRPIkG
0 5 K368-u AsCRRPIkGAAGRPL
0 14 S378-p AGRPLELsDFRMEEs
0 4 S385-p sDFRMEEsFSskyVP
0 1 S387 FRMEEsFSskyVPky
0 2 S388-p RMEEsFSskyVPkyV
0 26 K389-u MEEsFSskyVPkyVP
0 2 Y390-p EEsFSskyVPkyVPL
0 15 K393-u FSskyVPkyVPLADV
0 5 Y394-p SskyVPkyVPLADVk
0 42 K401-u yVPLADVkSEkTKKG
0 2 K404-u LADVkSEkTKKGRSI
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0 7 - gap
0 2 - gap
  TMPO iso2  
S9 PEFLEDPSVLTKDKL
T12 LEDPSVLTKDKLKSE
S18 LTKDKLKSELVANNV
T57 RPPLPAGTNSKGPPD
S59 PLPAGTNSKGPPDFS
K60 LPAGTNSKGPPDFSS
K60 LPAGTNSKGPPDFSS
S66 SKGPPDFSSDEEREP
S67 KGPPDFSSDEEREPT
R71 DFSSDEEREPTPVLG
T74 SDEEREPTPVLGSGA
S79 EPTPVLGSGAAAAGR
A83 VLGSGAAAAGRSRAA
R86 SGAAAAGRSRAAVGR
R86 SGAAAAGRSRAAVGR
S87 GAAAAGRSRAAVGRK
R88 AAAAGRSRAAVGRKA
R88 AAAAGRSRAAVGRKA
R93 RSRAAVGRKATKKTD
T96 AAVGRKATKKTDKPR
T99 GRKATKKTDKPRQED
K107 DKPRQEDKDDLDVTE
K126 DLLDQLVKYGVNPGP
Y127 LLDQLVKYGVNPGPI
T137 NPGPIVGTTRKLYEK
T154 LKLREQGTESRSSTP
S156 LREQGTESRSSTPLP
S158 EQGTESRSSTPLPTI
S159 QGTESRSSTPLPTIS
T160 GTESRSSTPLPTISS
T164 RSSTPLPTISSSAEN
S166 STPLPTISSSAENTR
S167 TPLPTISSSAENTRQ
S168 PLPTISSSAENTRQN
S177 ENTRQNGSNDSDRYS
S180 RQNGSNDSDRYSDNE
Y183 GSNDSDRYSDNEEDS
S184 SNDSDRYSDNEEDSK
S190 YSDNEEDSKIELKLE
K207 EPLKGRAKTPVTLKQ
T208 PLKGRAKTPVTLKQR
T211 GRAKTPVTLKQRRVE
K213 AKTPVTLKQRRVEHN
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- under review  
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K225 EHNQVGEKTEERRVE
K225-u EHNQVGEkTEERRVE
K237 RVERDILKEMFPYEA
Y242 ILKEMFPYEASTPTG
S245 EMFPYEASTPTGISA
T246 MFPYEASTPTGISAS
T248 PYEASTPTGISASCR
S251 ASTPTGISASCRRPI
S253 TPTGISASCRRPIKG
K259 ASCRRPIKGAAGRPL
S269 AGRPLELSDFRMEES
S276 SDFRMEESFSSKYVP
S278 FRMEESFSSKYVPKY
S279 RMEESFSSKYVPKYV
K280 MEESFSSKYVPKYVP
Y281 EESFSSKYVPKYVPL
K284 FSSKYVPKYVPLADV
Y285 SSKYVPKYVPLADVK
K292 YVPLADVKSEKTKKG
K295 LADVKSEKTKKGRSI
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  TMPO iso6  
S9 PEFLEDPSVLTKDKL
T12 LEDPSVLTKDKLKSE
S18 LTKDKLKSELVANNV
T57 RPPLPAGTNSKGPPD
S59 PLPAGTNSKGPPDFS
K60 LPAGTNSKGPPDFSS
K60 LPAGTNSKGPPDFSS
S66 SKGPPDFSSDEEREP
S67 KGPPDFSSDEEREPT
R71 DFSSDEEREPTPVLG
T74 SDEEREPTPVLGSGA
S79 EPTPVLGSGAAAAGR
A83 VLGSGAAAAGRSRAA
R86 SGAAAAGRSRAAVGR
R86 SGAAAAGRSRAAVGR
S87 GAAAAGRSRAAVGRK
R88 AAAAGRSRAAVGRKA
R88 AAAAGRSRAAVGRKA
R93 RSRAAVGRKATKKTD
T96 AAVGRKATKKTDKPR
T99 GRKATKKTDKPRQED
K107 DKPRQEDKDDLDVTE
K126 DLLDQLVKYGVNPGP
Y127 LLDQLVKYGVNPGPI
T137 NPGPIVGTTRKLYEK
T154 LKLREQGTESRSSTP
S156 LREQGTESRSSTPLP
S158 EQGTESRSSTPLPTI
S159 QGTESRSSTPLPTIS
T160 GTESRSSTPLPTISS
T164 RSSTPLPTISSSAEN
S166 STPLPTISSSAENTR
S167 TPLPTISSSAENTRQ
S168 PLPTISSSAENTRQN
S177 ENTRQNGSNDsDRys
S180-p RQNGSNDsDRysDNE
Y183-p GSNDsDRysDNEEGK
S184-p SNDsDRysDNEEGKK
K190 ysDNEEGKKKEHKKV
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- under review  
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T211-p VPFSELGttPSGGGF
T212-p PFSELGttPSGGGFF
S223 GGFFQGISFPEISTR
S228 GISFPEISTRPPLGS
T259-p PREPLVAtNLPGRGQ
S272-p GQLQKLAsERNLFIS
K281-u RNLFISCkSSHDRCL
S296-p EKSSSSSsQPEHSAM
S306-p EHSAMLVsTAAsPSL
S310-p MLVsTAAsPSLIKET
G331 DIVENICGREKSGIQ
S351-p RSHISDQsPLsSkRK
S354-p ISDQsPLsSkRKALE
K356-u DQsPLsSkRKALEES
K356-a DQsPLsSkRKALEES
S370-p SESSQLIsPPLAQAI
D413 ENIQKRIDQSkFQET
S415 IQKRIDQSkFQETEF
K416 QKRIDQSKFQETEFL
K416-u QKRIDQSkFQETEFL
F417 KRIDQSkFQETEFLs
F422 SkFQETEFLsPPRKV
S424-p FQETEFLsPPRKVPR
K435-u KVPRLSEkSVEERds
D441-ca EkSVEERdsGsFVAF
S442-p kSVEERdsGsFVAFQ
S444-p VEERdsGsFVAFQNI
T642-p EVKMAAHtMGNAtVG
T647-p AHtMGNAtVGRRYLW
K656-a GRRYLWLkDCkINLA
K659-u YLWLkDCkINLASkN
N661 WLkDCkINLASkNkL
K665-u CkINLASkNkLAstP
K667-u INLASkNkLAstPFk
S670-p ASkNkLAstPFkGGT
T671-p SkNkLAstPFkGGTL
K674-u kLAstPFkGGTLFGG
K685-u LFGGEVCkVIKKRGN
  mouse

► Hide Isoforms 		 
S9 PEFLEDPSVLTKDKL
T12 LEDPSVLTKDKLKSE
S18 LTKDKLKSELVANNV
A57 RPPLAAGANsKGPPD
S59-p PLAAGANsKGPPDFs
K60 LAAGANsKGPPDFss
K60 LAAGANsKGPPDFss
S66-p sKGPPDFssDEErEP
S67-p KGPPDFssDEErEPt
R71-m1 DFssDEErEPtPVLG
T74-p sDEErEPtPVLGsGA
S79-p EPtPVLGsGAsVGrG
S82-p PVLGsGAsVGrGrGA
R85-m1 GsGAsVGrGrGAVGr
R85-m2 GsGAsVGrGrGAVGr
G86 sGAsVGrGrGAVGrK
R87-m1 GAsVGrGrGAVGrKA
R87-m2 GAsVGrGrGAVGrKA
R92-m1 rGrGAVGrKATKKTD
T95 GAVGrKATKKTDKPR
T98 GrKATKKTDKPRLED
K106 DKPRLEDKDDLDVTE
R125 ELLDQLVRYGVNPGP
Y126 LLDQLVRYGVNPGPI
T136 NPGPIVGTTRKLYEK
T153-p LKLREQGtEsRsstP
S155-p LREQGtEsRsstPLP
S157-p EQGtEsRsstPLPtV
S158-p QGtEsRsstPLPtVs
T159-p GtEsRsstPLPtVss
T163-p RsstPLPtVsssAEN
S165-p stPLPtVsssAENTR
S166-p tPLPtVsssAENTRQ
S167-p PLPtVsssAENTRQN
S176-p ENTRQNGsNDsDRys
S179-p RQNGsNDsDRysDND
Y182-p GsNDsDRysDNDEDs
S183-p sNDsDRysDNDEDsK
S189-p ysDNDEDsKIELKLE
K206 EPLKGRAKtPVtLkQ
T207-p PLKGRAKtPVtLkQR
T210-p GRAKtPVtLkQRRTE
K212-u AKtPVtLkQRRTEHN
S221 RRTEHNQSYSQAGVt
Y222 RTEHNQSYSQAGVtE
S223 TEHNQSYSQAGVtET
T228-p SYSQAGVtETEWTSG
T246 GGPLQALTRESTRGS
S249 LQALTRESTRGSRRT
T250 QALTRESTRGSRRTP
S253 TRESTRGSRRTPRKR
T256 STRGSRRTPRKRVEt
T263-p TPRKRVEtSQHFRID
S264 PRKRVEtSQHFRIDG
S275 RIDGAVISEStPIAE
T278-p GAVISEStPIAETIk
K285-u tPIAETIkASsNEsL
S287 IAETIkASsNEsLVA
S288-p AETIkASsNEsLVAN
S291-p IkASsNEsLVANRLt
T298-p sLVANRLtGNFkHAs
K302-u NRLtGNFkHAssILP
S305-p tGNFkHAssILPITE
S306-p GNFkHAssILPITEF
T311 AssILPITEFsDITR
S314-p ILPITEFsDITRRTP
K322 DITRRTPKKPLTRAE
K323 ITRRTPKKPLTRAEV
K333 TRAEVGEKTEERRVD
K333-u TRAEVGEkTEERRVD
K345-u RVDRDILkEMFPYEA
Y350 ILkEMFPYEAStPTG
S353 EMFPYEAStPTGISA
T354-p MFPYEAStPTGISAs
T356 PYEAStPTGISAsCR
S359 AStPTGISAsCRRPI
S361-p tPTGISAsCRRPIKG
K367 AsCRRPIKGAAGRPL
S377-p AGRPLELsDFRMEEs
S384-p sDFRMEEsFsSkYVP
S386-p FRMEEsFsSkYVPkY
S387 RMEEsFsSkYVPkYA
K388-u MEEsFsSkYVPkYAP
Y389 EEsFsSkYVPkYAPL
K392-u FsSkYVPkYAPLADV
Y393 sSkYVPkYAPLADVk
K400-u YAPLADVkSEkTKKR
K403-u LADVkSEkTKKRRSV
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  TMPO iso6  
S9 PEFLEDPSVLTKDKL
T12 LEDPSVLTKDKLKSE
S18 LTKDKLKSELVANNV
A57 RPPLAAGANSKGPPD
S59 PLAAGANSKGPPDFS
K60 LAAGANSKGPPDFSS
K60 LAAGANSKGPPDFSS
S66 SKGPPDFSSDEErEP
S67 KGPPDFSSDEErEPT
R71-m1 DFSSDEErEPTPVLG
T74 SDEErEPTPVLGSGA
S79 EPTPVLGSGASVGrG
S82 PVLGSGASVGrGrGA
R85-m1 GSGASVGrGrGAVGr
R85 GSGASVGRGrGAVGr
G86 SGASVGrGrGAVGrK
R87-m1 GASVGrGrGAVGrKA
R87 GASVGrGRGAVGrKA
R92-m1 rGrGAVGrKATKKTD
T95 GAVGrKATKKTDKPR
T98 GrKATKKTDKPRLED
K106 DKPRLEDKDDLDVTE
R125 ELLDQLVRYGVNPGP
Y126 LLDQLVRYGVNPGPI
T136 NPGPIVGTTRKLYEK
T153 LKLREQGTESRSSTP
S155 LREQGTESRSSTPLP
S157 EQGTESRSSTPLPTV
S158 QGTESRSSTPLPTVS
T159 GTESRSSTPLPTVSS
T163 RSSTPLPTVSSSAEN
S165 STPLPTVSSSAENTR
S166 TPLPTVSSSAENTRQ
S167 PLPTVSSSAENTRQN
S176 ENTRQNGSNDSDRYs
S179 RQNGSNDSDRYsDND
Y182 GSNDSDRYsDNDEGK
S183-p SNDSDRYsDNDEGKK
K189 YsDNDEGKKKEHKKV
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- under review  
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S210 VPFSELASTPSGAFF
T211 PFSELASTPSGAFFQ
S221-p GAFFQGIsFPEIsTR
S226-p GIsFPEIsTRPPLGR
T257 PRETCTDTALPGKGQ
P270 GQTHKLAPGRSLFIP
E279 RSLFIPSESSYDRCV
S294 EKSSSPSSQREFAAR
S304-p EFAARLVsAAAsPSL
S308-p RLVsAAAsPSLIRET
R329-m1 DIVENICrGGKSRAQ
S349 EPGVSDQSVFSSERE
S352 VSDQSVFSSEREVLQ
E354 DQSVFSSEREVLQES
E354 DQSVFSSEREVLQES
S368 SERSQVISPPLAQAI
S411-p ENICKRLsQssyQDS
S413-p ICKRLsQssyQDSEs
S414-p CKRLsQssyQDSEsL
S414 CKRLsQsSyQDSEsL
Y415-p KRLsQssyQDSEsLs
S420-p ssyQDSEsLsPPRKV
S422-p yQDSEsLsPPRKVPR
K433 KVPRLSEKPARGGDS
D439 EKPARGGDSGSCVAF
S440 KPARGGDSGSCVAFQ
S442 ARGGDSGSCVAFQNT
A641 EVRMSACAMGSSTMG
T646 ACAMGSSTMGRRYLW
K655 GRRYLWLKDCKIsPA
K658 YLWLKDCKIsPASKN
S660-p WLKDCKIsPASKNKL
K664 CKIsPASKNKLTVAP
K666 IsPASKNKLTVAPFK
V669 ASKNKLTVAPFKGGT
A670 SKNKLTVAPFKGGTL
K673 KLTVAPFKGGTLFGG
K684 LFGGEVHKVIKKRGN
  rat

 
S9 PEFLEDPSVLTKDKL
T12 LEDPSVLTKDKLKSE
S18 LTKDKLKSELVANNV
A57 RPPLAAGANSKGPPD
S59 PLAAGANSKGPPDFs
K60 LAAGANSKGPPDFss
K60 LAAGANSKGPPDFss
S66-p SKGPPDFssDEEREP
S67-p KGPPDFssDEEREPt
R71 DFssDEEREPtPVLG
T74-p sDEEREPtPVLGSGA
S79 EPtPVLGSGASVGrG
S82 PVLGSGASVGrGrGA
R85-m1 GSGASVGrGrGAVGr
R85 GSGASVGRGrGAVGr
G86 SGASVGrGrGAVGrK
R87-m1 GASVGrGrGAVGrKA
R87 GASVGrGRGAVGrKA
R92-m1 rGrGAVGrKATKKTD
T95 GAVGrKATKKTDKPR
T98 GrKATKKTDKPRPED
K106 DKPRPEDKDDLDVTE
R125 ELLEQLVRYGVNPGP
Y126 LLEQLVRYGVNPGPI
T136 NPGPIVGTTRKLYEK
A153 LKLREQGAESRSSTP
S155 LREQGAESRSSTPLP
S157 EQGAESRSSTPLPTV
S158 QGAESRSSTPLPTVS
T159 GAESRSSTPLPTVSS
T163 RSSTPLPTVSSSAEN
S165 STPLPTVSSSAENTR
S166 TPLPTVSSSAENTRQ
S167 PLPTVSSSAENTRQN
S176 ENTRQNGSNDSDRYS
S179 RQNGSNDSDRYSDND
Y182 GSNDSDRYSDNDEDS
S183 SNDSDRYSDNDEDSK
S189 YSDNDEDSKIELKLE
K206 EPLKGRAKTPVTLKQ
T207 PLKGRAKTPVTLKQR
T210 GRAKTPVTLKQRRIE
K212 AKTPVTLKQRRIEHN
S221 RRIEHNQSYSEAGVT
Y222 RIEHNQSYSEAGVTE
S223 IEHNQSYSEAGVTET
T228 SYSEAGVTETEWTSG
T246 GGPLQALTRESTRGS
S249 LQALTRESTRGSRRT
T250 QALTRESTRGSRRTP
S253 TRESTRGSRRTPRRR
T256 STRGSRRTPRRRVEP
P263 TPRRRVEPsQHFRVD
S264-p PRRRVEPsQHFRVDG
S275 RVDGAVISESTPIAE
T278 GAVISESTPIAETIK
K285 TPIAETIKASSNDSL
S287 IAETIKASSNDSLVA
S288 AETIKASSNDSLVAN
S291 IKASSNDSLVANRLT
T298 SLVANRLTGNFKHAS
K302 NRLTGNFKHASSILP
S305 TGNFKHASSILPITE
S306 GNFKHASSILPITEF
T311 ASSILPITEFSDITR
S314 ILPITEFSDITRRTP
K322 DITRRTPKKPLTRAE
K323 ITRRTPKKPLTRAEV
K333 TRAEVGEKTEERRVE
K333 TRAEVGEKTEERRVE
K345 RVERDILKEMFPYEA
Y350 ILKEMFPYEASTPTG
S353 EMFPYEASTPTGISA
T354 MFPYEASTPTGISAS
T356 PYEASTPTGISASCR
S359 ASTPTGISASCRRPI
S361 TPTGISASCRRPIKG
K367 ASCRRPIKGAAGRPL
S377 AGRPLELSDFRMEES
S384 SDFRMEESFSSKYVP
S386 FRMEESFSSKYVPKY
S387 RMEESFSSKYVPKYV
K388 MEESFSSKYVPKYVP
Y389 EESFSSKYVPKYVPL
K392 FSSKYVPKYVPLADV
Y393 SSKYVPKYVPLADVK
K400 YVPLADVKSEKTKKG
K403 LADVKSEKTKKGRSV
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