Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q21
Cellular Component: mitochondrial outer membrane; nuclear membrane; mitochondrion; membrane; integral to membrane; cytosol
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity
Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.