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Protein Page:
Drosha (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Drosha a nuclear type-III RNase that, along with the DGCR8, executes the initial step of microRNA (miRNA) processing in the nucleus. Cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) into pre-miRNAs. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Interacts with Sp1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Nucleolus; EC 3.1.26.3; RNA binding protein; Ribonuclease
Cellular Component: nucleoplasm; nucleolus
Molecular Function: protein binding; ribonuclease III activity; lipopolysaccharide binding; metal ion binding
Biological Process: defense response to Gram-positive bacterium; pre-microRNA processing; rRNA catabolic process; ribosome biogenesis and assembly; gene expression; primary microRNA processing; defense response to Gram-negative bacterium
Reference #:  Q9NRR4 (UniProtKB)
Alt. Names/Synonyms: Drosha; drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ETOHI2; HSA242976; nuclear RNase III Drosha; p241; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; RANSE3L; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RN3; RNase III; RNASE3L; RNASEN; RNC
Gene Symbols: DROSHA
Molecular weight: 159,316 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Drosha

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S300‑p, S302‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S221-p KAPSERRsPERLKHy
0 5 Y228-p sPERLKHyDDHRHRD
0 1 S237-p DHRHRDHsHGRGERH
0 1 S267-p RQDSRYRsDyDRGRt
0 1 Y269-p DSRYRsDyDRGRtPs
0 1 T274-p sDyDRGRtPsRHRSY
0 1 S276-p yDRGRtPsRHRSYER
2 9 S300-p RHRDNRRsPsLERSy
2 6 S302-p RDNRRsPsLERSyKK
0 1 S306 RsPsLERSyKKEYKR
0 1 Y307-p sPsLERSyKKEYKRS
0 2 S355-p LEIVNHRsPsREKKR
0 2 S357-p IVNHRsPsREKKRAR
0 4 S373-p EEEKDRWsDNQSSGK
0 1 S491-p ECESDEDsTCSSSSD
0 1 S698-p DGGKEVLsMHQILLy
0 1 Y705-p sMHQILLyLLRCSKA
0 1 T747-p MIVTNPGtKPSSVRI
0 1 S796-p QYQKLWKsYVKLRHL
0 1 S807-p LRHLLANsPKVKQTD
0 1 K1250-ub VCFFPRLkEFILNQD
0 1 S1293-p TLQTVGPsHARTYTV
  mouse

 
S219 KAQNERRSPERLKHY
Y226 SPERLKHYDDHRHRD
S235 DHRHRDHSHGRGERH
S265 RPESRYRSDYDRGRT
Y267 ESRYRSDYDRGRTPP
T272 SDYDRGRTPPPRHRS
P275 DRGRTPPPRHRSYER
S299-p RHREARRsPsLERsY
S301-p REARRsPsLERsYKK
S305-p RsPsLERsYKKEYKR
Y306 sPsLERsYKKEYKRS
S354 PENVNHRSPSREKKR
S356 NVNHRSPSREKKRAR
S372 EEEKDRWSDSQGSGK
S490 ECETDDDSTCSSSSD
S697 DGGKEVLSMHQILLY
Y704 SMHQILLYLLRCSKA
T746 MIVTNPGTKPSSVRI
S795 QYQKLWKSYVKLRHL
S806 LRHLLANSPKVKQTD
K1249 VCFFPRLKEFILNQD
S1292 TLQTVGPSHARTYTV
  rat

 
S213 KAQSERRSPERLKHY
Y220 SPERLKHYDDHRHRD
S229 DHRHRDHSHGRGERH
S259 RPESRYRSEYDRGRT
Y261 ESRYRSEYDRGRTPP
- under review  
- under review  
S293 RHRENRRSPSLERAY
S295 RENRRSPSLERAYKK
A299 RSPSLERAYKKEYKR
Y300 SPSLERAYKKEYKRS
S348 QENVNHRSPSREKKR
S350 NVNHRSPSREKKRAR
S366 EEEKDRWSDSQSSGK
S484 ECETDEDSTCSSSSD
S691 DGGKEVLSMHQILLY
Y698 SMHQILLYLLRCSKA
T740 MIVTNPGTKPSSVRI
S789 QYQKLWKSYVKLRHL
S800 LRHLLANSPKVKQTD
- under review  
- under review  
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