a nuclear type-III RNase that, along with the DGCR8, executes the initial step of microRNA (miRNA) processing in the nucleus. Cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) into pre-miRNAs. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Interacts with Sp1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; RNA binding protein; Ribonuclease; RNA processing
Cellular Component: nucleoplasm; nucleolus
Molecular Function: protein binding; ribonuclease III activity; lipopolysaccharide binding; metal ion binding
Biological Process: defense response to Gram-positive bacterium; pre-microRNA processing; rRNA catabolic process; ribosome biogenesis and assembly; gene expression; primary microRNA processing; defense response to Gram-negative bacterium
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.