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Protein Page:
Drosha (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Drosha a nuclear type-III RNase that, along with the DGCR8, executes the initial step of microRNA (miRNA) processing in the nucleus. Cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) into pre-miRNAs. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Interacts with Sp1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.26.3; Ribonuclease; RNA binding protein; RNA processing
Cellular Component: nucleoplasm; nucleolus
Molecular Function: protein binding; ribonuclease III activity; metal ion binding
Biological Process: pre-microRNA processing; rRNA catabolic process; ribosome biogenesis and assembly; gene expression; primary microRNA processing
Reference #:  Q9NRR4 (UniProtKB)
Alt. Names/Synonyms: Drosha; drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ETOHI2; HSA242976; nuclear RNase III Drosha; p241; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; RANSE3L; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RN3; RNase III; RNASE3L; RNASEN; RNC
Gene Symbols: DROSHA
Molecular weight: 159,316 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Drosha

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S300‑p, S302‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y228-p SPERLKHyDDHRHRD
0 1 S237-p DHRHRDHsHGRGERH
2 8 S300-p RHRDNRRsPsLERSy
2 5 S302-p RDNRRsPsLERSyKK
0 1 Y307-p sPsLERSyKKEYKRS
0 1 S355-p LEIVNHRsPsREKKR
0 1 S357-p IVNHRsPsREKKRAR
0 3 S373-p EEEKDRWsDNQSSGK
0 1 S796-p QYQKLWKsYVKLRHL
0 1 S807-p LRHLLANsPKVKQTD
0 1 K1250-u VCFFPRLkEFILNQD
  mouse

 
Y226 SPERLKHYDDHRHRD
S235 DHRHRDHSHGRGERH
S299-p RHREARRsPsLERSY
S301-p REARRsPsLERSYKK
Y306 sPsLERSYKKEYKRS
S354 PENVNHRSPSREKKR
S356 NVNHRSPSREKKRAR
S372 EEEKDRWSDSQGSGK
S795 QYQKLWKSYVKLRHL
S806 LRHLLANSPKVKQTD
K1249 VCFFPRLKEFILNQD
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