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Drosha (human)

Overview Drosha a nuclear type-III RNase that, along with the DGCR8, executes the initial step of microRNA (miRNA) processing in the nucleus. Cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) into pre-miRNAs. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Interacts with Sp1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: RNA processing; Ribonuclease; RNA binding protein; EC 3.1.26.3 Cellular Component: nucleoplasm; nucleolus Molecular Function: protein binding; ribonuclease III activity; metal ion binding; double-stranded RNA binding Biological Process: pre-microRNA processing; rRNA catabolic process; ribosome biogenesis and assembly; gene expression Reference #:  Q9NRR4 (UniProtKB) Alt. Names/Synonyms: Drosha; drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ETOHI2; HSA242976; nuclear RNase III Drosha; p241; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; RANSE3L; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RN3; RNase III; RNASE3L; RNASEN; RNC Gene Symbols: DROSHA Molecular weight: 159,316 Da Basal Isoelectric point: 8  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Drosha 2KHX - A=1259-1337 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S300‑p, S302‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S221-p	KAPSERRsPERLKHy
0	2		Y228-p	sPERLKHyDDHRHRD
0	1		S237-p	DHRHRDHsHGRGERH
0	1		S267-p	RQDSRYRsDyDRGRt
0	1		Y269-p	DSRYRsDyDRGRtPs
0	1		T274-p	sDyDRGRtPsRHRSY
0	1		S276-p	yDRGRtPsRHRSYER
2	7		S300-p	RHRDNRRsPsLERSy
2	5		S302-p	RDNRRsPsLERSyKK
0	1		Y307-p	sPsLERSyKKEYKRS
0	2		S373-p	EEEKDRWsDNQSSGK
0	1		S491-p	ECESDEDsTCSSSSD
0	1		S698-p	DGGKEVLsMHQILLy
0	1		Y705-p	sMHQILLyLLRCSKA
0	1		T747-p	MIVTNPGtKPSSVRI
0	1		S796-p	QYQKLWKsYVKLRHL
0	1		K1250-u	VCFFPRLkEFILNQD
0	1		S1293-p	TLQTVGPsHARTYTV

	mouse
S219	KAQNERRSPERLKHY
Y226	SPERLKHYDDHRHRD
S235	DHRHRDHSHGRGERH
S265	RPESRYRSDYDRGRT
Y267	ESRYRSDYDRGRTPP
T272	SDYDRGRTPPPRHRS
P275	DRGRTPPPRHRSYER
S299-p	RHREARRsPsLERSY
S301-p	REARRsPsLERSYKK
Y306	sPsLERSYKKEYKRS
S372	EEEKDRWSDSQGSGK
S490	ECETDDDSTCSSSSD
S697	DGGKEVLSMHQILLY
Y704	SMHQILLYLLRCSKA
T746	MIVTNPGTKPSSVRI
S795	QYQKLWKSYVKLRHL
K1249	VCFFPRLKEFILNQD
S1292	TLQTVGPSHARTYTV

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