Home

AMPKG3 (human)

Overview AMPKG3 AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Skeletal muscle, with weak expression in heart and pancreas. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, regulatory subunit; Kinase, protein Cellular Component: cytosol; AMP-activated protein kinase complex Molecular Function: AMP-activated protein kinase activity; protein kinase binding; ATP binding Biological Process: glycogen biosynthetic process; insulin receptor signaling pathway; protein kinase cascade; regulation of fatty acid oxidation; glucose transport; cell cycle arrest; fatty acid biosynthetic process Reference #:  Q9UGI9 (UniProtKB) Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-3; 5'-AMP-activated protein kinase, gamma-3 subunit; AAKG3; AMPK gamma-3 chain; AMPK gamma3; AMPK subunit gamma-3; AMPKG3; PRKAG3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit Gene Symbols: PRKAG3 Molecular weight: 54,258 Da Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AMPKG3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T323-p	GNVLHILtHKRLLKF
0	1		T92	ESTGLEATFPKTTPL
0	1		S336-p	KFLHIFGsLLPRPSF

	mouse
T323	GTVLYILTHKRLLKF
T91-p	ESTRQEAtFPKATPL
A336	KFLHIFGALLPRPSF

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.