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P2X1
Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death. Belongs to the P2X receptor family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Channel, ligand-gated |
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Cellular Component: postsynaptic membrane; protein complex; integral to plasma membrane; plasma membrane; lipid raft
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Molecular Function: zinc ion binding; calcium channel activity; cation channel activity; drug binding; ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity
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Biological Process: caspase activation; platelet activation; synaptic transmission, glutamatergic; vasoconstriction; protein heterooligomerization; insemination; generation of action potential; regulation of calcium ion transport; signal transduction; response to ATP; transport; serotonin secretion by platelet; regulation of blood pressure; regulation of vascular smooth muscle contraction; ceramide biosynthetic process; ion transport; positive regulation of ion transport; blood coagulation; protein homooligomerization; cation transport
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Reference #:
P51575 (UniProtKB)
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| Alt. Names/Synonyms: ATP receptor; P2RX1; P2X purinoceptor 1; P2X receptor, subunit 1; P2X1; P2X1 receptor; Purinergic receptor; purinergic receptor P2X, ligand-gated ion channel, 1 |
| Gene Symbols: P2RX1 |
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Molecular weight: 44,980 Da
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Basal Isoelectric point: 8.75
Predict pI for various phosphorylation states
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