Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PSEN2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSEN2 probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.23.-; Membrane protein, multi-pass; Membrane protein, integral; Cell surface; Protease
Cellular Component: Golgi apparatus; centrosome; cell surface; lysosomal membrane; integral to plasma membrane; nuclear inner membrane; cytosol; lipid raft; ciliary rootlet; kinetochore; membrane; cell soma; perinuclear region of cytoplasm; mitochondrial inner membrane; apical plasma membrane; dendritic shaft; neuromuscular junction; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cell cortex; Z disc; Golgi membrane; growth cone; axon; plasma membrane
Molecular Function: protein binding; endopeptidase activity; aspartic-type endopeptidase activity
Biological Process: positive regulation of catalytic activity; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; regulation of synaptic plasticity; positive regulation of coagulation; cell fate specification; T cell receptor signaling pathway; T cell activation during immune response; protein transport; amyloid precursor protein catabolic process; negative regulation of protein amino acid phosphorylation; beta-amyloid metabolic process; calcium ion transport; forebrain development; brain morphogenesis; negative regulation of protein binding; locomotion; dorsoventral neural tube patterning; embryonic limb morphogenesis; cardiac muscle contraction; Notch signaling pathway; somitogenesis; membrane protein intracellular domain proteolysis; thymus development; regulation of epidermal growth factor receptor activity; membrane protein ectodomain proteolysis; Notch receptor processing; memory; endoplasmic reticulum calcium ion homeostasis; response to hypoxia; myeloid leukocyte differentiation; hemopoietic progenitor cell differentiation; protein processing; anagen; negative regulation of protein complex assembly; alveolus development; negative regulation of apoptosis
Reference #:  P49810 (UniProtKB)
Alt. Names/Synonyms: AD3L; AD3LP; AD4; AD5; Alzheimer's disease 3-like; E5-1; presenilin 2 (Alzheimer disease 4); Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PS2; PSEN2; PSN2; PSNL2; STM-2; STM2
Gene Symbols: PSEN2
Molecular weight: 50,140 Da
Basal Isoelectric point: 4.51  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSEN2

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, inhibited: S327‑p, S330‑p
protein stabilization: S327‑p, S330‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S7-p _MLTFMAsDsEEEVC
1 0 S9-p LTFMAsDsEEEVCDE
0 1 T18 EEVCDERTsLMsAEs
1 0 S19-p EVCDERTsLMsAEsP
0 10 S22-p DERTsLMsAEsPtPR
0 16 S25-p TsLMsAEsPtPRSCQ
0 2 T27-p LMsAEsPtPRSCQEG
0 1 P28 MsAEsPtPRSCQEGR
0 2 S30 AEsPtPRSCQEGRQG
0 3 S49-p ENTAQWRsQENEEDG
0 5 N52 AQWRsQENEEDGEED
0 1 K115-ub SVRFYTEkNGQLIYT
0 1 Y294-p PIFPALIySSAMVWT
0 1 K306-ac VWTVGMAkLDPSSQG
2 0 S327-p DPEMEEDsYDsFGEP
2 0 S330-p MEEDsYDsFGEPsYP
1 0 S335-p YDsFGEPsYPEVFEP
  mouse

 
S7 _MLAFMASDSEEEVC
S9 LAFMASDSEEEVCDE
T18-p EEVCDERtSLMsAEs
S19 EVCDERtSLMsAEsP
S22-p DERtSLMsAEsPtsR
S25-p tSLMsAEsPtsRsCQ
T27-p LMsAEsPtsRsCQEG
S28-p MsAEsPtsRsCQEGR
S30-p AEsPtsRsCQEGRPG
T49-p ESTAQWRtQEsEEDC
S52-p AQWRtQEsEEDCEED
K115 SVRFYTEKNGQLIYT
Y294 PIFPALIYSSAMVWT
K306 VWTVGMAKLDPSSQG
S327 DPEMEEDSYDSFGEP
S330 MEEDSYDSFGEPSYP
S335 YDSFGEPSYPEAFEA
  rat

 
S7 _MLTFMASDSEEEVC
S9 LTFMASDSEEEVCDE
T18 EEVCDERTSLMSAEs
S19 EVCDERTSLMSAEsP
S22 DERTSLMSAEsPTSR
S25-p TSLMSAEsPTSRSCQ
T27 LMSAEsPTSRSCQDS
S28 MSAEsPTSRSCQDSR
S30 AEsPTSRSCQDSRPG
S49 ENTAQWRSQENEDDC
N52 AQWRSQENEDDCEED
K115 SVRFYTEKNGQLIYT
Y294 PIFPALIYSSAMVWT
K306 VWTVGMAKLDPSSQG
S327 DPEMEEDSYDSFGEP
S330 MEEDSYDSFGEPSYP
S335 YDSFGEPSYPEAFEA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.