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Protein Page:
FOXK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXK2 Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; magnesium ion binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q01167 (UniProtKB)
Alt. Names/Synonyms: Cellular transcription factor ILF-1; forkhead box K2; Forkhead box protein K2; FOXK1; FOXK2; ILF; ILF-1; ILF1; interleukin enhancer binding factor 1; Interleukin enhancer-binding factor 1
Gene Symbols: FOXK2
Molecular weight: 69,062 Da
Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXK2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S373‑p, S428‑p
transcription, altered: S373‑p, S428‑p
protein stabilization: S373‑p, S428‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 T13-p AALSGAGtPPAGGGA
0 8 S30-p GGAGGGGsPPGGWAV
0 4 S61-p VTIGRNSsQGSVDVS
0 2 R144-m1 LPRVCTFrFPSTNIK
0 3 S170-p EKQEASEsPVKAVQP
0 1 S199-p HLISPLPsPTGTISA
0 5 S239-p LNLMADNsQPENEKE
0 1 Y295-p ITKNYPYyRTADKGW
0 2 K328-ac RSQEEPGkGSFWRID
0 20 S369-p LGPLSSRsAPAsPNH
0 1 S369 LGPLSSRSAPAsPNH
1 34 S373-p SSRsAPAsPNHAGVL
0 10 S381-p PNHAGVLsAHssGAQ
0 5 S384-p AGVLsAHssGAQtPE
0 10 S385-p GVLsAHssGAQtPES
1 26 T389-p AHssGAQtPESLsRE
0 2 S392 sGAQtPESLsREGsP
0 16 S394-p AQtPESLsREGsPAP
1 60 S398-p ESLsREGsPAPLEPE
0 1 A409 LEPEPGAAQPKLAVI
0 17 S424-p QEARFAQsAPGsPLs
0 1 S424 QEARFAQSAPGsPLs
1 25 S428-p FAQsAPGsPLsSQPV
0 2 S431-p sAPGsPLsSQPVLIT
0 2 S432 APGsPLsSQPVLITV
0 1 G535 VEPIPAIGHATLGTA
0 1 S543 HATLGTASRIIQTAQ
0 1 T552-p IIQTAQTtPVQTVtI
0 1 T558-p TtPVQTVtIVQQAPL
0 1 S584-p QNGTHVAsVPtAVHG
0 2 T587-p THVAsVPtAVHGQVN
0 3 S599-p QVNNAAAsPLHMLAT
0 90 T634-p PELKRIKtEDGEGIV
0 4 T648-p VIALSVDtPPAAVRE
  mouse

 
A12 AALSGAGAPPAGGGA
S24-p GGAGGGGsPPGGWAV
S55 VTIGRNSSQGSVDVS
R135 LPRVCTFRFPSTNIK
S161 EKQEAPESPVKPVQP
S190 HLISPLPSPTGTISA
S230-p LSLMADNsQPENEKE
Y286 ITKNYPYYRTADKGW
K319 RSQEEPGKGSFWRID
S360-p LGPLSSRsAPAsPNH
S360-gl LGPLSSRsAPAsPNH
S364-p SSRsAPAsPNHAGVL
S372-p PNHAGVLsAHssGAQ
S375-p AGVLsAHssGAQtPE
S376-p GVLsAHssGAQtPEs
T380-p AHssGAQtPEsLsRE
S383-p sGAQtPEsLsREGsP
S385-p AQtPEsLsREGsPAP
S389-p EsLsREGsPAPLEPE
S400-p LEPEPGAsQPKLAVI
S415-p QEARFAQsAPGsPLs
S415-gl QEARFAQsAPGsPLs
S419-p FAQsAPGsPLssQPV
S422-p sAPGsPLssQPVLIT
S423-p APGsPLssQPVLITV
S526-p VEPVPAIsPATLGAA
S534-p PATLGAAsRIIQTSQ
T543 IIQTSQGTPVQTVTI
T549 GTPVQTVTIVQQAPL
P575 QNGAHVVPMPTAVHS
T578 AHVVPMPTAVHSQVN
S590-p QVNNAAAsPLHMLAT
A625 PELKRVKAEDGESIV
A639 VIALSVDAPPAAVRE
  rat

 
- gap
- gap
- gap
- gap
S25 EKQEAPESPVKPVQP
S54 HLISPLPSPTGTISA
S94 LNLMADNSQPENEKE
Y150 ITKNYPYYRTADKGW
K183 RSQEEPGKGSFWRID
S224 LGPLSSRSAPASPNH
S224 LGPLSSRSAPASPNH
S228 SSRSAPASPNHAGVL
S236 PNHAGVLSAHSSGAQ
S239 AGVLSAHSSGAQTPE
S240 GVLSAHSSGAQTPES
T244 AHSSGAQTPESLSRE
S247 SGAQTPESLSREGsP
S249 AQTPESLSREGsPAP
S253-p ESLSREGsPAPLEPE
S264 LEPEPGASQPKLAVI
S279 QEARFAQSAPGsPLS
S279 QEARFAQSAPGsPLS
S283-p FAQSAPGsPLSSQPV
S286 SAPGsPLSSQPVLIT
S287 APGsPLSSQPVLITV
S389 VEPVPAISPATLGAA
S397 PATLGAASRIIQTSQ
T406 IIQTSQGTPVQTVTI
T412 GTPVQTVTIVQQAPL
P438 QNGTHVVPMPTAVHS
T441 THVVPMPTAVHSQVN
S453 QVNNAVASPLHMLAT
A488 PELKRVKAEDGESIV
A502 VIALSVDAPPAAVRE
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