Home

FOXK2 (human)

Overview FOXK2 Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: transcription factor complex; intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; sequence-specific DNA binding; double-stranded DNA binding; magnesium ion binding; transcription factor activity; transcription factor binding; DNA bending activity Biological Process: regulation of transcription from RNA polymerase II promoter; tissue development; embryonic development; regulation of transcription factor activity; regulation of transcription, DNA-dependent; pattern specification process Reference #:  Q01167 (UniProtKB) Alt. Names/Synonyms: Cellular transcription factor ILF-1; forkhead box K2; Forkhead box protein K2; FOXK1; FOXK2; ILF; ILF-1; ILF1; interleukin enhancer binding factor 1; Interleukin enhancer-binding factor 1 Gene Symbols: FOXK2 Molecular weight: 69,062 Da Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXK2 1JXS - A=251-348 (human) 2C6Y - A/B=251-348 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1JXS 2C6Y  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S373‑p, S428‑p transcription, altered: S373‑p, S428‑p protein stabilization: S373‑p, S428‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S30-p	GGAGGGGsPPGGWAV
0	1		S61-p	VTIGRNSsQGSVDVS
0	1		R144-m1	LPRVCTFrFPSTNIK
0	2		S170-p	EKQEASEsPVKAVQP
0	2		S239-p	LNLMADNsQPENEKE
0	1		Y295-p	ITKNYPYyRTADKGW
0	2		K328-a	RSQEEPGkGSFWRID
0	18		S369-p	LGPLSSRsAPAsPNH
0	1		S369	LGPLSSRSAPAsPNH
1	30		S373-p	SSRsAPAsPNHAGVL
0	9		S381-p	PNHAGVLsAHssGAQ
0	5		S384-p	AGVLsAHssGAQtPE
0	7		S385-p	GVLsAHssGAQtPES
1	27		T389-p	AHssGAQtPESLsRE
0	2		S392	sGAQtPESLsREGsP
0	15		S394-p	AQtPESLsREGsPAP
1	47		S398-p	ESLsREGsPAPLEPE
0	1		A409	LEPEPGAAQPKLAVI
0	11		S424-p	QEARFAQsAPGsPLs
0	1		S424	QEARFAQSAPGsPLs
1	18		S428-p	FAQsAPGsPLsSQPV
0	1		S431-p	sAPGsPLsSQPVLIT
0	1		S432	APGsPLsSQPVLITV
0	1		S543	HATLGTASRIIQTAQ
0	1		S584-p	QNGTHVAsVPtAVHG
0	2		T587-p	THVAsVPtAVHGQVN
0	1		S599	QVNNAAASPLHMLAT
0	89		T634-p	PELKRIKtEDGEGIV
0	4		T648-p	VIALSVDtPPAAVRE

	mouse
S24-p	GGAGGGGsPPGGWAV
S55	VTIGRNSSQGSVDVS
R135	LPRVCTFRFPSTNIK
S161	EKQEAPESPVKPVQP
S230-p	LSLMADNsQPENEKE
Y286	ITKNYPYYRTADKGW
K319	RSQEEPGKGSFWRID
S360-p	LGPLSSRsAPAsPNH
S360-gl	LGPLSSRsAPAsPNH
S364-p	SSRsAPAsPNHAGVL
S372-p	PNHAGVLsAHssGAQ
S375-p	AGVLsAHssGAQtPE
S376-p	GVLsAHssGAQtPEs
T380-p	AHssGAQtPEsLsRE
S383-p	sGAQtPEsLsREGsP
S385-p	AQtPEsLsREGsPAP
S389-p	EsLsREGsPAPLEPE
S400-p	LEPEPGAsQPKLAVI
S415-p	QEARFAQsAPGsPLs
S415-gl	QEARFAQsAPGsPLs
S419-p	FAQsAPGsPLssQPV
S422-p	sAPGsPLssQPVLIT
S423-p	APGsPLssQPVLITV
S534-p	PATLGAAsRIIQTSQ
P575	QNGAHVVPMPTAVHS
T578	AHVVPMPTAVHSQVN
S590-p	QVNNAAAsPLHMLAT
A625	PELKRVKAEDGESIV
A639	VIALSVDAPPAAVRE

	rat
S24	GGAGGGGSPPGGWAV
S55	VTIGRNSSQGSVDVS
R135	LPRVCTFRFPSTNIK
S161	EKQEAPESPVKPVQP
S230	LNLMADNSQPENEKE
Y286	ITKNYPYYRTADKGW
K319	RSQEEPGKGSFWRID
S360	LGPLSSRSAPASPNH
S360	LGPLSSRSAPASPNH
S364	SSRSAPASPNHAGVL
S372	PNHAGVLSAHSSGAQ
S375	AGVLSAHSSGAQTPE
S376	GVLSAHSSGAQTPES
T380	AHSSGAQTPESLSRE
S383	SGAQTPESLSREGSP
S385	AQTPESLSREGSPAP
S389	ESLSREGSPAPLEPE
S400	LEPEPGASQPKLAVI
S415	QEARFAQSAPGSPLS
S415	QEARFAQSAPGSPLS
S419	FAQSAPGSPLSSQPV
S422	SAPGSPLSSQPVLIT
S423	APGSPLSSQPVLITV
-	gap
-	gap
-	gap
S519	REVRAVASPLHMLAT
A554	PELKRVKAEDGESIV
A568	VIALSVDAPPAAVRE

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.