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Protein Page:
RGS4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RGS4 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs, RGS; GAPs
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: protein complex; cytoplasm; plasma membrane; cytosol
Molecular Function: calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity
Biological Process: regulation of G-protein coupled receptor protein signaling pathway; inactivation of MAPK activity; positive regulation of GTPase activity
Reference #:  P49798 (UniProtKB)
Alt. Names/Synonyms: DKFZp761F1924; MGC2124; MGC60244; Regulator of G-protein signaling 4; regulator of G-protein signalling 4; RGP4; RGS4; schizophrenia disorder 9; SCZD9
Gene Symbols: RGS4
Molecular weight: 23,256 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RGS4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 R22 SAKDMKHRLGFLLQK
1 0 S52 VVICQRVSQEEVKKW
1 0 S103 EEYKKIKSPSKLSPK
1 1 S108 IKSPSKLSPKAKKIY
  RGS4 iso3  
S78-p AKYAQSRsHsssCRI
S80-p YAQSRsHsssCRISF
S81-p AQSRsHsssCRISFL
S82-p QSRsHsssCRISFLL
S92-p ISFLLANsKLLNKMC
R119 SAKDMKHRLGFLLQK
S149 VVICQRVSQEEVKKW
S200 EEYKKIKSPSKLSPK
S205 IKSPSKLSPKAKKIY
  mouse

 
- gap
- gap
- gap
- gap
- gap
R22-m2 SAKDMKHrLGFLLQK
S52 VVTCQRVSQEEVKKW
S103 EEYKKIKSPSKLsPK
S108-p IKSPSKLsPKAKKIY
  rat

 
- gap
- gap
- gap
- gap
- gap
R22 SAKDMKHRLGFLLQK
S52 VVTCQRVSQEEVKKW
S103 EEYKKIKSPSKLSPK
S108 IKSPSKLSPKAKKIY
  rabbit

 
- gap
- gap
- gap
- gap
- gap
R22 SAKDMKHRLGFLLQK
S52-p VVVCQRVsQEEVKKW
S103-p EEYKKIKsPSKLsPK
S108-p IKsPSKLsPKAKKIY
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