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RGS4
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: GTPase activating protein, RGS |
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Cellular Component: cytoplasm; plasma membrane; cytosol
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Molecular Function: calmodulin binding; GTPase activator activity
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Biological Process: regulation of G-protein coupled receptor protein signaling pathway; inactivation of MAPK activity; positive regulation of GTPase activity
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Reference #:
P49798 (UniProtKB)
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| Alt. Names/Synonyms: DKFZp761F1924; MGC2124; MGC60244; Regulator of G-protein signaling 4; regulator of G-protein signalling 4; RGP4; RGS4; schizophrenia disorder 9; SCZD9 |
| Gene Symbols: RGS4 |
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Molecular weight: 23,256 Da
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Basal Isoelectric point: 8.69
Predict pI for various phosphorylation states
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CST Pathways:
GPCRs Signaling to MAPK/Erk
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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