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Protein Page:
RGS4 (human)

Overview
RGS4 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs, RGS; GAPs
Cellular Component: protein complex; cytoplasm; plasma membrane; cytosol
Molecular Function: calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity
Biological Process: regulation of G-protein coupled receptor protein signaling pathway; inactivation of MAPK activity
Reference #:  P49798 (UniProtKB)
Alt. Names/Synonyms: DKFZp761F1924; MGC2124; MGC60244; Regulator of G-protein signaling 4; regulator of G-protein signalling 4; RGP4; RGS4; schizophrenia disorder 9; SCZD9
Gene Symbols: RGS4
Molecular weight: 23,256 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RGS4

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 S52 VVICQRVSQEEVKKW
1 0 S103 EEYKKIKSPSKLSPK
1 1 S108 IKSPSKLSPKAKKIY
  RGS4 iso3  
S149 VVICQRVSQEEVKKW
S200 EEYKKIKSPSKLSPK
S205 IKSPSKLSPKAKKIY
  mouse

 
S52 VVTCQRVSQEEVKKW
S103 EEYKKIKSPSKLsPK
S108-p IKSPSKLsPKAKKIY
  rat

 
S52 VVTCQRVSQEEVKKW
S103 EEYKKIKSPSKLSPK
S108 IKSPSKLSPKAKKIY
  rabbit

 
S52-p VVVCQRVsQEEVKKW
S103-p EEYKKIKsPSKLsPK
S108-p IKsPSKLsPKAKKIY
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