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LEF-1
a transcription factor of the TCF/LEF family. Participates in the Wnt signaling pathway and regulates T-cell receptor alpha-C enhancer function. Activates transcription of target genes in the presence of CTNNB1 and EP300. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. Deletions in LEF1 have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Four human isoforms produced by alternative promoter usage and alternative splicing have been described. Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription factor |
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Cellular Component: transcription factor complex; cytoplasm; nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; estrogen receptor activity; histone binding; caspase inhibitor activity; beta-catenin binding; transcription factor binding; protein binding; DNA binding; sequence-specific DNA binding; gamma-catenin binding; estrogen receptor binding; chromatin binding; transcription factor activity; DNA bending activity
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Biological Process: skin development; radial glial cell differentiation in the forebrain; hypothalamus development; positive regulation of transcription, DNA-dependent; T-helper 1 cell differentiation; Wnt receptor signaling pathway through beta-catenin; forebrain neuroblast division; forebrain neuron differentiation; BMP signaling pathway; negative regulation of interleukin-13 production; kidney development; neural crest cell migration; embryonic limb morphogenesis; regulation of striated muscle development; somitogenesis; organ regeneration; dentate gyrus development; sensory perception of taste; negative regulation of striated muscle development; positive regulation of cell growth; patterning of blood vessels; neurogenesis; negative regulation of interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; B cell proliferation; negative regulation of interleukin-4 production; tongue development; paraxial mesoderm formation; response to lithium ion; positive regulation of granulocyte differentiation; alpha-beta T cell differentiation; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; palate development; anatomical structure regression; regulation of cell-cell adhesion; mammary gland development; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; muscle fiber development; Wnt receptor signaling pathway; neutrophil differentiation; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; formation of radial glial scaffolds; osteoblast differentiation; generation of neurons; induction of apoptosis; T cell receptor V(D)J recombination; epithelial to mesenchymal transition; negative regulation of cell-cell adhesion; sprouting angiogenesis; brain development; eye pigmentation; positive regulation of cell migration
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Reference #:
Q9UJU2 (UniProtKB)
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| Alt. Names/Synonyms: DKFZp586H0919; FLJ46390; LEF-1; LEF1; Lymphoid enhancer-binding factor 1; T cell-specific transcription factor 1-alpha; TCF1-alpha; TCF1ALPHA |
| Gene Symbols: LEF1 |
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Molecular weight: 44,201 Da
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Basal Isoelectric point: 6.9
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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