|
Fyn
a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Src family |
|
Cellular Component: membrane; intracellular membrane-bound organelle; mitochondrion; postsynaptic density; plasma membrane; endosome
|
|
Molecular Function: tubulin binding; CD8 receptor binding; ephrin receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase activity; transferase activity; protein binding; peptide hormone receptor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein complex binding; T cell receptor binding; phosphoinositide 3-kinase binding; kinase activity; glycoprotein binding; CD4 receptor binding; ATP binding; receptor binding
|
|
Biological Process: myelination; peptidyl-tyrosine phosphorylation; dendrite morphogenesis; protein amino acid autophosphorylation; multicellular organismal development; activated T cell proliferation; neuron migration; T cell receptor signaling pathway; protein amino acid phosphorylation; detection of mechanical stimulus involved in sensory perception of pain; regulation of cell shape; response to ethanol; cell surface receptor linked signal transduction; forebrain development; negative regulation of protein catabolic process; phosphorylation
|
|
Reference #:
P39688 (UniProtKB)
|
| Alt. Names/Synonyms: AI448320; AW552119; Fyn; Fyn proto-oncogene; MGC115870; p59-Fyn; Proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; Src Kinase p59; Tyrosine-protein kinase Fyn |
| Gene Symbols: Fyn |
|
Molecular weight: 60,656 Da
|
|
Basal Isoelectric point: 6.35
Predict pI for various phosphorylation states
|
|
CST Pathways:
Adherens Junction Dynamics
|
GPCRs Signaling to MAPK/Erk
|
Insulin Receptor Signaling
|
MAPK/Erk in Growth and Differentiation
|
Tyrosine Kinases
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
