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Protein Page:
UBE1L2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBE1L2 Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Belongs to the ubiquitin-activating E1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; FAT10 activating enzyme activity; ATP binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; protein ubiquitination
Reference #:  A0AVT1 (UniProtKB)
Alt. Names/Synonyms: FLJ10808; FLJ23367; Monocyte protein 4; MOP-4; MOP4; UBA6; UBA6, ubiquitin-activating enzyme E1; UBE1L2; Ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1-like 2; Ubiquitin-activating enzyme E1-like protein 2; ubiquitin-like modifier activating enzyme 6; Ubiquitin-like modifier-activating enzyme 6
Gene Symbols: UBA6
Molecular weight: 117,970 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UBE1L2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S16-p AHQGEEAsCSSWGTG
0 2 S36-p LPIMSTAsVEIDDAL
0 2 Y44-p VEIDDALySRQRYVL
0 1 T54-p QRYVLGDtAMQKMAK
0 1 T136 LNPYVHVTSSSVPFN
0 1 T146-p SVPFNETtDLsFLDK
0 1 S149-p FNETtDLsFLDKYQC
0 2 K238-ub CLENHPHkLEtGQFL
0 1 T241-p NHPHkLEtGQFLtFR
0 1 T246-p LEtGQFLtFREINGM
0 1 K295-ub AVQVKTPkTVFFEsL
0 1 S301-p PkTVFFEsLERQLKH
0 1 T494 SKEKGMITVTDPDLI
0 1 T496 EKGMITVTDPDLIEk
0 2 K503-ub TDPDLIEkSNLNRQF
0 1 S504 DPDLIEkSNLNRQFL
0 3 K544-ac KIDAHLNkVCPTTET
0 42 K544-ub KIDAHLNkVCPTTET
0 1 K628-ub EIPFCTLkSFPAAIE
0 1 T637-p FPAAIEHtIQWARDk
0 1 K644-ub tIQWARDkFESSFSH
0 2 K652-ub FESSFSHkPSLFNKF
0 1 K687-ub EGCFQVIkLLSRRPR
0 1 K729-ub FPLDIRLkDGSLFWQ
0 4 S737-p DGSLFWQsPkRPPsP
0 6 K739-ub SLFWQsPkRPPsPIK
0 19 S743-p QsPkRPPsPIKFDLN
0 1 S779 PFAEEDLSADALLNI
0 2 K830-ub NAIFQLEkAILSNEA
0 1 E836 EkAILSNEATKSDLQ
0 1 K839 ILSNEATKSDLQMAV
0 1 K882 IEPADRFKTKRIAGk
0 17 K889-ub KTKRIAGkIIPAIAT
0 1 Y979-p INAVKEKyGIEPTMV
0 1 Y994-p VQGVKMLyVPVMPGH
0 2 K1003-ac PVMPGHAkRLKLTMH
  mouse

 
S16 VLSCEEASCSSWGAC
S36 LPTMTTESLEIDDGL
Y44 LEIDDGLYSRQRYVL
T54 QRYVLGDTAMQKMAK
S136-p LNPYVQVsSSSAPLD
T146 SAPLDETTDLSFLEK
S149 LDETTDLSFLEKYQC
K238 CLESHPHKLETGQFL
T241 SHPHKLETGQFLTFR
T246 LETGQFLTFREIHGM
K295 AVQVKTPKTFCFEPL
P301 PKTFCFEPLESQIKH
T494 GREKGMVTVTDPDLI
T496 EKGMVTVTDPDLIEk
K503-ub TDPDLIEkSNLNRQF
S504 DPDLIEkSNLNRQFL
K544 KIDAHLNKVCPATES
K544-ub KIDAHLNkVCPATES
K628 EIPFCTLKSFPAAIE
T637 FPAAIEHTIQWARDK
K644 TIQWARDKFESSFSH
K652-ub FESSFSHkPSLFNKF
K687 EGCFQVIKLLSRRPR
K729 FPLETRLKDGSLFWQ
S737 DGSLFWQSPkRPPsP
K739-ub SLFWQSPkRPPsPIK
S743-p QSPkRPPsPIKFDLN
S779-p PFSEKDLsVNSLMDI
E830 NAVFQLEEALSSNkA
K836-ub EEALSSNkATkSDLQ
K839-ub LSSNkATkSDLQMTV
K882-ub IEPADRFkTKRIAGk
K889-ub kTKRIAGkIIPAIAT
Y979 INAVKENYGIEPTMV
Y994 VQGVKMLYVPVMPGH
K1003 PVMPGHAKRLKLTMH
  rat

 
S16 VLSCEEASCSSWGAC
S36 LPTMTTESLEIDDGL
Y44 LEIDDGLYSRQRYVL
T54 QRYVLGDTAMQKMAK
S136 LNPYVQVSSSSAPFD
T146 SAPFDETTDLSFLEK
S149 FDETTDLSFLEKYQC
K238 CLENHPHKLETGQFL
T241 NHPHKLETGQFLTFR
T246 LETGQFLTFREINGM
K295 AVQVKTPKIFNFEPL
P301 PKIFNFEPLESQIKH
T494-p GREKGMVtVtDPDLI
T496-p EKGMVtVtDPDLIEK
K503 tDPDLIEKsNLNRQF
S504-p DPDLIEKsNLNRQFL
K544 KIDAHLNKVCPATES
K544 KIDAHLNKVCPATES
K628 EIPFCTLKSFPAAVE
T637 FPAAVEHTIQWARDK
K644 TIQWARDKFESSFSH
K652 FESSFSHKPSLFNKF
K687 EGCFQVIKLLSRRPR
K729 FPLDTRLKDGSLFWQ
S737 DGSLFWQSPKRPPSP
K739 SLFWQSPKRPPSPIK
S743 QSPKRPPSPIKFDLN
S779-p PFSEKDLsVDSLMDI
K830 NAVFQLEKALSSNKA
K836 EKALSSNKATKSDLQ
K839 LSSNKATKSDLQMAV
K882 IEPADRFKTKRIAGK
K889 KTKRIAGKIIPAIAT
Y979 INAVKEKYGIEPTMV
Y994 VQGVKMLYVPVMPGH
K1003-ac PVMPGHAkRLKLTMH
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