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Protein Page:
PSEN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSEN1 probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function. Five alternative splice isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Mitochondrial; EC 3.4.23.-; Membrane protein, integral; Protease; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: Golgi apparatus; centrosome; nuclear outer membrane; smooth endoplasmic reticulum; cell surface; mitochondrion; lysosomal membrane; integral to plasma membrane; integral to membrane; lipid raft; kinetochore; ciliary rootlet; cell soma; membrane; perinuclear region of cytoplasm; apical plasma membrane; mitochondrial inner membrane; cytoplasmic vesicle; dendritic shaft; neuromuscular junction; endoplasmic reticulum membrane; nuclear membrane; rough endoplasmic reticulum; endoplasmic reticulum; cell cortex; Z disc; Golgi membrane; growth cone; axon
Molecular Function: protein binding; cadherin binding; calcium channel activity; endopeptidase activity; beta-catenin binding; aspartic-type endopeptidase activity; PDZ domain binding
Biological Process: positive regulation of catalytic activity; extracellular matrix organization and biogenesis; activation of MAPKK activity; positive regulation of apoptosis; beta-amyloid formation; regulation of synaptic plasticity; positive regulation of coagulation; Wnt receptor signaling pathway through beta-catenin; choline transport; T cell receptor signaling pathway; post-embryonic development; T cell activation during immune response; mitochondrial transport; extracellular matrix disassembly; positive regulation of MAP kinase activity; cell-cell adhesion; epithelial cell proliferation; negative regulation of axonogenesis; negative regulation of neuron apoptosis; autophagic vacuole formation; embryonic limb morphogenesis; somitogenesis; regulation of phosphorylation; skin morphogenesis; Notch receptor processing; negative regulation of ubiquitin-protein ligase activity; neuron development; hemopoietic progenitor cell differentiation; Cajal-Retzius cell differentiation; response to oxidative stress; anagen; negative regulation of apoptosis; regulation of synaptic transmission, glutamatergic; neuron migration; protein amino acid glycosylation; cell fate specification; negative regulation of transcription from RNA polymerase II promoter; protein transport; amyloid precursor protein catabolic process; beta-amyloid metabolic process; regulation of resting membrane potential; brain morphogenesis; heart looping; positive regulation of receptor recycling; dorsoventral neural tube patterning; blood vessel development; Notch signaling pathway; L-glutamate transport; thymus development; membrane protein ectodomain proteolysis; memory; negative regulation of epidermal growth factor receptor activity; smooth endoplasmic reticulum calcium ion homeostasis; neuron apoptosis; endoplasmic reticulum calcium ion homeostasis; cerebral cortex cell migration; skeletal morphogenesis; regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid leukocyte differentiation; protein processing; synaptic vesicle targeting; response to DNA damage stimulus
Reference #:  P49768 (UniProtKB)
Alt. Names/Synonyms: AD3; FAD; presenilin 1; Presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS-1; PS1; PS1-CTF12; PSEN1; PSN1; PSNL1; S182
Gene Symbols: PSEN1
Molecular weight: 52,668 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSEN1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S346‑p
cell growth, altered: S353‑p, S357‑p
enzymatic activity, induced: S319‑p, T320‑p, T354‑p
intracellular localization: S353‑p, S357‑p
molecular association, regulation: S353‑p, S357‑p
protein conformation: S353‑p, S357‑p
protein stabilization: S319‑p, T320‑p, T354‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 8 S43-p QEHNDRRsLGHPEPL
0 3 S51-p LGHPEPLsNGRPQGN
0 1 S102-p VVVATIKsVsFYTRk
0 1 S104-p VATIKsVsFYTRkDG
0 2 K109-ub sVsFYTRkDGQLIYT
0 1 Y154-p TILLVVLyKYRCYKV
1 0 S310-p PEAQRRVsKNSkYNA
0 1 K314-ub RRVsKNSkYNAEstE
1 0 S319-p NSkYNAEstEREsQD
1 0 T320-p SkYNAEstEREsQDT
0 3 S324-p AEstEREsQDTVAEN
0 1 T327 tEREsQDTVAENDDG
0 6 A329 REsQDTVAENDDGGF
0 1 N331 sQDTVAENDDGGFSE
1 0 S346-p EWEAQRDsHLGPHRs
3 3 S353-p sHLGPHRstPEsRAA
2 14 T354-p HLGPHRstPEsRAAV
3 3 S357-p PHRstPEsRAAVQEL
0 11 S365-p RAAVQELsssILAGE
0 6 S366-p AAVQELsssILAGED
0 32 S367-p AVQELsssILAGEDP
0 21 A370 ELsssILAGEDPEER
0 14 G371 LsssILAGEDPEERG
0 1 - gap
  PSEN1 iso3  
S39 QEHNDRRSLGHPEPL
S47 LGHPEPLSNGRPQGN
S98 VVVATIKSVSFYTRK
S100 VATIKSVSFYTRKDG
K105 SVSFYTRKDGQLIYT
Y150 TILLVVLYKYRCYKV
S306 PEAQRRVSKNSKYNA
K310 RRVSKNSKYNAERAC
R315 NSKYNAERACLPPAA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S363-p QRMMMAGsVRNGKPR
  mouse

 
R43 QQQHDRQRLDNPEPI
S51 LDNPEPISNGRPQSN
S102 VVVATIKSVSFYTRK
S104 VATIKSVSFYTRKDG
K109 SVSFYTRKDGQLIYT
Y154 TILLVVLYKYRCYKV
P310 PEAQRRVPKNPKYNT
K314 RRVPKNPKYNTQRAE
R319 NPKYNTQRAEREtQD
A320 PKYNTQRAEREtQDs
T324-p TQRAEREtQDsGsGN
S327-p AEREtQDsGsGNDDG
S329-p REtQDsGsGNDDGGF
N331 tQDsGsGNDDGGFSE
S346 EWEAQRDSHLGPHRS
S353 SHLGPHRStPESRAA
T354-p HLGPHRStPESRAAV
S357 PHRStPESRAAVQEL
S365-p RAAVQELsGsILtsE
G366 AAVQELsGsILtsED
S367-p AVQELsGsILtsEDP
T370-p ELsGsILtsEDPEER
S371-p LsGsILtsEDPEERG
- gap
  rat

 
R42 QQHHDRQRLDNPESI
S50-p LDNPESIsNGRPQSN
S102 VVVATIKSVSFYTRK
S104 VATIKSVSFYTRKDG
K109 SVSFYTRKDGQLIYT
Y154 TILLVVLYKYRCYKV
P310 PEAQRRVPKNPKYST
K314 RRVPKNPKYSTQGTE
G319 NPKYSTQGTEREETQ
T320 PKYSTQGTEREETQD
T325 QGTEREETQDTGtGs
T328 EREETQDTGtGsDDG
T330-p EETQDTGtGsDDGGF
S332-p TQDTGtGsDDGGFSE
S347 EWEAQRDSHLGPHRS
S354 SHLGPHRSTPESRAA
T355 HLGPHRSTPESRAAV
S358 PHRSTPESRAAVQEL
S366 RAAVQELSGsILtsE
G367 AAVQELSGsILtsED
S368-p AVQELSGsILtsEDP
T371-p ELSGsILtsEDPEER
S372-p LSGsILtsEDPEERG
- gap
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