a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Nuclear receptor co-regulator; DNA binding protein
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; DNA binding; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor activity; DNA bending activity
Biological Process: transcription from RNA polymerase II promoter; blood vessel development; tissue development; transcription, DNA-dependent; apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; glucose homeostasis; negative regulation of stress-activated MAPK cascade; pattern specification process; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of gluconeogenesis; embryonic development; regulation of transcription, DNA-dependent; cellular response to insulin stimulus; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.