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Protein Page:
FOXO1A (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXO1A a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Nuclear receptor co-regulator; DNA binding protein
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein binding; DNA binding; protein phosphatase 2A binding; sequence-specific DNA binding; ubiquitin protein ligase binding; protein kinase binding; DNA bending activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; tissue development; positive regulation of apoptosis; apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; organ development; positive regulation of autophagy; blood vessel development; transcription, DNA-dependent; negative regulation of fat cell differentiation; negative regulation of stress-activated MAPK cascade; cellular response to starvation; pattern specification process; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; embryonic development; cellular response to insulin stimulus; positive regulation of protein catabolic process; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; negative regulation of apoptosis
Reference #:  Q9R1E0 (UniProtKB)
Alt. Names/Synonyms: Afxh; AI876417; Fkhr; Fkhr1; forkhead box O1; forkhead box O1a; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead protein 1; Foxo1; Foxo1a; OTTMUSP00000023486
Gene Symbols: Foxo1
Molecular weight: 69,518 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  G1/S Checkpoint  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXO1A

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: T24‑p, S253‑p, S316‑p, S319‑p, S499‑p
intracellular localization: T24‑p, S253‑p, S316‑p
phosphorylation: S253‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
46 42 T24-p LPRQRSCtWPLPRPE
3 0 S209-p SSAGWKNsIRHNLSL
1 0 S215 NsIRHNLSLHSKFIR
1 0 K219 HNLSLHSKFIRVQNE
1 0 S231 QNEGTGKSSWWMLNP
1 0 S232 NEGTGKSSWWMLNPE
5 0 K242 MLNPEGGKSGKsPRR
5 0 K245 PEGGKSGKsPRRRAA
11 2 S246-p EGGKSGKsPRRRAAs
1 0 R248 GKSGKsPRRRAAsMD
1 0 R250 SGKsPRRRAAsMDNN
68 41 S253-p sPRRRAAsMDNNSKF
3 0 K259 AsMDNNSKFAKSRGR
5 0 K262 DNNSKFAKSRGRAAK
2 0 K271 RGRAAKKKASLQSGQ
4 14 S284-p GQEGPGDsPGSQFSK
0 1 S290 DsPGSQFSKWPAsPG
1 0 K291 sPGSQFSKWPAsPGS
6 35 S295-p QFSKWPAsPGSHsND
0 8 S298 KWPAsPGSHsNDDFD
0 7 S300-p PAsPGSHsNDDFDNW
1 0 T314 WSTFRPRTSsNAstI
1 0 S315 STFRPRTSsNAstIs
21 29 S316-p TFRPRTSsNAstIsG
7 0 S319-p PRTSsNAstIsGRLs
0 2 T320-p RTSsNAstIsGRLsP
6 0 S322-p SsNAstIsGRLsPIM
8 25 S326-p stIsGRLsPIMtEQD
0 2 T330-p GRLsPIMtEQDDLGD
2 0 S380-p DNLNLLSsPTSLTVS
1 0 S391-p LTVSTQSsPGSMMQQ
1 0 T399-p PGSMMQQtPCYSFAP
4 0 S413-p PPNTSLNsPsPNYSK
4 0 S415-p NTSLNsPsPNYSKYT
2 2 S429-p TYGQSSMsPLPQMPM
0 1 S465-p LLKELLTsDsPPHND
3 4 S467-p KELLTsDsPPHNDIM
3 0 S475-p PPHNDIMsPVDPGVA
1 0 S499-p NVMMGPNsVMPAYGS
0 1 P502 MGPNsVMPAYGSQAS
0 1 S506 sVMPAYGSQASHNKM
1 0 S547 VNTMPHTSAMNRLtP
1 0 T553-p TSAMNRLtPVKtPLQ
1 0 T557-p NRLtPVKtPLQVPLS
0 1 K594 MGVLHQEKLPSDLDG
1 0 T645 FPHSVKTTTHSWVSG
1 0 T646 PHSVKTTTHSWVSG_
0 1 S648 SVKTTTHSWVSG___
1 0 S651 TTTHSWVSG______
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9461 : Phospho-FoxO1 (Ser256) Antibody
2486 : Phospho-FoxO1 (Ser319) Antibody
  human

 
T24-p LPRPRSCtWPLPRPE
S212-p SSAGWKNsIRHNLsL
S218-p NsIRHNLsLHSkFIR
K222-ac HNLsLHSkFIRVQNE
S234-p QNEGTGKssWWMLNP
S235-p NEGTGKssWWMLNPE
K245-ac MLNPEGGkSGksPrR
K248-ac PEGGkSGksPrRrAA
S249-p EGGkSGksPrRrAAs
R251-me GkSGksPrRrAAsMD
R253-me SGksPrRrAAsMDNN
S256-p sPrRrAAsMDNNSkF
K262-ac AsMDNNSkFAkSRSR
K265-ac DNNSkFAkSRSRAAK
K274-ac RSRAAKKkASLQSGQ
S287-p GQEGAGDsPGSQFsk
S293-p DsPGSQFskWPAsPG
K294-ac sPGSQFskWPAsPGs
S298-p QFskWPAsPGsHsND
S301-p kWPAsPGsHsNDDFD
S303-p PAsPGsHsNDDFDNW
T317-gl WSTFRPRtssNAstI
S318-gl STFRPRtssNAstIs
S319-p TFRPRtssNAstIsG
S322-p PRtssNAstIsGRLs
T323-p RtssNAstIsGRLsP
S325-p ssNAstIsGRLsPIM
S329-p stIsGRLsPIMtEQD
T333-p GRLsPIMtEQDDLGE
S383-p DNLNLLSsPTSLTVS
S394-p LTVSTQSsPGTMMQQ
T402-p PGTMMQQtPCYSFAP
S416-p PPNTSLNsPsPNYQK
S418-p NTSLNsPsPNYQKYT
S432-p TYGQSSMsPLPQMPI
S468-p LLKELLTsDsPPHND
S470-p KELLTsDsPPHNDIM
T478 PPHNDIMTPVDPGVA
S502 NVMMGPNSVMsTYGs
S505-p MGPNSVMsTYGsQAS
S509-p SVMsTYGsQASHNKM
S550-gl VSTMPHTsGMNRLTQ
T556 TsGMNRLTQVKTPVQ
T560 NRLTQVKTPVQVPLP
K597-ac MGLLHQEkLPSDLDG
T648-gl FPHSVKTttHsWVsG
T649-p PHSVKTttHsWVsG_
S651-p SVKTttHsWVsG___
S654-gl TttHsWVsG______
2599 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32)/FoxO4 (Thr28) (4G6) Rabbit mAb
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9461 : Phospho-FoxO1 (Ser256) Antibody
2486 : Phospho-FoxO1 (Ser319) Antibody
  rat

 
T24-p LPRQRSCtWPLPRPE
S206-p SSAGWKNsIRHNLSL
S212 NsIRHNLSLHSKFIR
K216 HNLSLHSKFIRVQNE
S228 QNEGTGKSSWWMLNP
S229 NEGTGKSSWWMLNPE
K239 MLNPEGGKSGKsPRR
K242 PEGGKSGKsPRRRAA
S243-p EGGKSGKsPRRRAAs
R245 GKSGKsPRRRAAsMD
R247 SGKsPRRRAAsMDNN
S250-p sPRRRAAsMDNNSkF
K256-ac AsMDNNSkFAKSRGR
K259 DNNSkFAKSRGRAAK
K268 RGRAAKKKASLQSGQ
S281-p GQEGPGDsPGSQFSK
S287 DsPGSQFSKWPASPG
K288 sPGSQFSKWPASPGS
S292 QFSKWPASPGSHSND
S295 KWPASPGSHSNDDFD
S297 PASPGSHSNDDFDNW
T311 WSTFRPRTSsNAsTI
S312 STFRPRTSsNAsTIs
S313-p TFRPRTSsNAsTIsG
S316-p PRTSsNAsTIsGRLs
T317 RTSsNAsTIsGRLsP
S319-p SsNAsTIsGRLsPIM
S323-p sTIsGRLsPIMTEQD
T327 GRLsPIMTEQDDLGD
S377 DNLNLLSSPTSLTVS
S388 LTVSTQSSPGSMMQQ
T396 PGSMMQQTPCYSFAP
S410 PPNTSLNSPSPNYAK
S412 NTSLNSPSPNYAKYT
S426 TYGQSSMSPVPQMPM
S462 LLKELLTSDSPPHND
S464 KELLTSDSPPHNDIM
S472 PPHNDIMSPVDPGVA
S496 NVLMGPNSVMPAYGS
P499 MGPNSVMPAYGSQAP
S503 SVMPAYGSQAPHNKM
S544 VNTMPHTSAMNRLTP
T550 TSAMNRLTPVKTPLQ
T554 NRLTPVKTPLQVPLS
K591 MGVLHQEKLPSDLDG
T642 FPHSVKTTTHSWVSG
T643 PHSVKTTTHSWVSG_
S645 SVKTTTHSWVSG___
S648 TTTHSWVSG______
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
2486 : Phospho-FoxO1 (Ser319) Antibody
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