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FOXO1A (mouse)

Overview FOXO1A a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor; Nuclear receptor co-regulator Cellular Component: transcription factor complex; cytoplasm; cytosol; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; protein phosphatase 2A binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding; protein kinase binding; transcription factor activity; DNA bending activity Biological Process: tissue development; blood vessel development; transcription, DNA-dependent; apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of stress-activated MAPK cascade; pattern specification process; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of gluconeogenesis; embryonic development; regulation of transcription, DNA-dependent; regulation of transcription factor activity; organ development; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; negative regulation of apoptosis Reference #:  Q9R1E0 (UniProtKB) Alt. Names/Synonyms: Afxh; AI876417; Fkhr; Fkhr1; forkhead box O1; forkhead box O1a; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead protein 1; Foxo1; Foxo1a; OTTMUSP00000023486 Gene Symbols: Foxo1 Molecular weight: 69,518 Da Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXO1A 3CO6 - C=150-249 (human) 3CO7 - C/F=150-266 (human) 3COA - C/F=150-266 (human)

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	Sites Implicated In
transcription, altered: T24‑p, S253‑p, S316‑p, S319‑p, S499‑p intracellular localization: T24‑p, S253‑p, S316‑p phosphorylation: S253‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
42	38		T24-p	LPRQRSCtWPLPRPE
2	0		S209	SSAGWKNSIRHNLSL
1	0		S215	NSIRHNLSLHSKFIR
1	0		K219	HNLSLHSKFIRVQNE
1	0		S231	QNEGTGKSSWWMLNP
1	0		S232	NEGTGKSSWWMLNPE
5	0		K242	MLNPEGGKSGKsPRR
5	0		K245	PEGGKSGKsPRRRAA
10	2		S246-p	EGGKSGKsPRRRAAs
1	0		R248	GKSGKsPRRRAAsMD
1	0		R250	SGKsPRRRAAsMDNN
65	37		S253-p	sPRRRAAsMDNNSKF
2	0		K259	AsMDNNSKFAKSRGR
4	0		K262	DNNSKFAKSRGRAAK
1	0		K271	RGRAAKKKASLQSGQ
4	7		S284-p	GQEGPGDsPGSQFSK
0	1		S290	DsPGSQFSKWPAsPG
1	0		K291	sPGSQFSKWPAsPGS
5	29		S295-p	QFSKWPAsPGSHsND
0	7		S298	KWPAsPGSHsNDDFD
0	6		S300-p	PAsPGSHsNDDFDNW
1	0		T314	WSTFRPRTSsNAsTI
1	0		S315	STFRPRTSsNAsTIs
20	19		S316-p	TFRPRTSsNAsTIsG
6	0		S319-p	PRTSsNAsTIsGRLs
5	0		S322-p	SsNAsTIsGRLsPIM
8	13		S326-p	sTIsGRLsPIMtEQD
0	1		T330-p	GRLsPIMtEQDDLGD
1	0		S380-p	DNLNLLSsPTSLTVS
1	0		S391-p	LTVSTQSsPGSMMQQ
1	0		T399-p	PGSMMQQtPCYSFAP
4	0		S413-p	PPNTSLNsPsPNYSK
4	0		S415-p	NTSLNsPsPNYSKYT
2	1		S429-p	TYGQSSMsPLPQMPM
0	1		S465-p	LLKELLTsDsPPHND
3	2		S467-p	KELLTsDsPPHNDIM
3	0		S475-p	PPHNDIMsPVDPGVA
1	0		S499-p	NVMMGPNsVMPAYGS
0	1		P502	MGPNsVMPAYGSQAS
0	1		S506	sVMPAYGSQASHNKM
1	0		S547	VNTMPHTSAMNRLtP
1	0		T553-p	TSAMNRLtPVKtPLQ
1	0		T557-p	NRLtPVKtPLQVPLS
0	1		K594	MGVLHQEKLPSDLDG
1	0		T645	FPHSVKTTTHSWVSG
0	1		S648	SVKTTTHSWVSG___
1	0		S651	TTTHSWVSG______

	human
T24-p	LPRPRSCtWPLPRPE
S212-p	SSAGWKNsIRHNLsL
S218-p	NsIRHNLsLHSkFIR
K222-a	HNLsLHSkFIRVQNE
S234-p	QNEGTGKssWWMLNP
S235-p	NEGTGKssWWMLNPE
K245-a	MLNPEGGkSGksPrR
K248-a	PEGGkSGksPrRrAA
S249-p	EGGkSGksPrRrAAs
R251-m	GkSGksPrRrAAsMD
R253-m	SGksPrRrAAsMDNN
S256-p	sPrRrAAsMDNNSkF
K262-a	AsMDNNSkFAkSRSR
K265-a	DNNSkFAkSRSRAAK
K274-a	RSRAAKKkASLQSGQ
S287-p	GQEGAGDsPGSQFsk
S293-p	DsPGSQFskWPAsPG
K294-a	sPGSQFskWPAsPGs
S298-p	QFskWPAsPGsHsND
S301-p	kWPAsPGsHsNDDFD
S303-p	PAsPGsHsNDDFDNW
T317-g	WSTFRPRtssNAsTI
S318-g	STFRPRtssNAsTIs
S319-p	TFRPRtssNAsTIsG
S322-p	PRtssNAsTIsGRLs
S325-p	ssNAsTIsGRLsPIM
S329-p	sTIsGRLsPIMTEQD
T333	GRLsPIMTEQDDLGE
S383-p	DNLNLLSsPTSLTVS
S394-p	LTVSTQSsPGTMMQQ
T402-p	PGTMMQQtPCYSFAP
S416-p	PPNTSLNsPsPNYQK
S418-p	NTSLNsPsPNYQKYT
S432-p	TYGQSSMsPLPQMPI
S468	LLKELLTSDsPPHND
S470-p	KELLTSDsPPHNDIM
T478	PPHNDIMTPVDPGVA
S502	NVMMGPNSVMsTYGs
S505-p	MGPNSVMsTYGsQAS
S509-p	SVMsTYGsQASHNKM
S550-g	VSTMPHTsGMNRLTQ
T556	TsGMNRLTQVKTPVQ
T560	NRLTQVKTPVQVPLP
K597-a	MGLLHQEkLPSDLDG
T648-g	FPHSVKTtTHsWVsG
S651-p	SVKTtTHsWVsG___
S654-g	TtTHsWVsG______

	rat
T24-p	LPRQRSCtWPLPRPE
S206-p	SSAGWKNsIRHNLSL
S212	NsIRHNLSLHSKFIR
K216	HNLSLHSKFIRVQNE
S228	QNEGTGKSSWWMLNP
S229	NEGTGKSSWWMLNPE
K239	MLNPEGGKSGKsPRR
K242	PEGGKSGKsPRRRAA
S243-p	EGGKSGKsPRRRAAs
R245	GKSGKsPRRRAAsMD
R247	SGKsPRRRAAsMDNN
S250-p	sPRRRAAsMDNNSKF
K256	AsMDNNSKFAKSRGR
K259	DNNSKFAKSRGRAAK
K268	RGRAAKKKASLQSGQ
S281-p	GQEGPGDsPGSQFSK
S287	DsPGSQFSKWPASPG
K288	sPGSQFSKWPASPGS
S292	QFSKWPASPGSHSND
S295	KWPASPGSHSNDDFD
S297	PASPGSHSNDDFDNW
T311	WSTFRPRTSsNAsTI
S312	STFRPRTSsNAsTIs
S313-p	TFRPRTSsNAsTIsG
S316-p	PRTSsNAsTIsGRLs
S319-p	SsNAsTIsGRLsPIM
S323-p	sTIsGRLsPIMTEQD
T327	GRLsPIMTEQDDLGD
S377	DNLNLLSSPTSLTVS
S388	LTVSTQSSPGSMMQQ
T396	PGSMMQQTPCYSFAP
S410	PPNTSLNSPSPNYAK
S412	NTSLNSPSPNYAKYT
S426	TYGQSSMSPVPQMPM
S462	LLKELLTSDSPPHND
S464	KELLTSDSPPHNDIM
S472	PPHNDIMSPVDPGVA
S496	NVLMGPNSVMPAYGS
P499	MGPNSVMPAYGSQAP
S503	SVMPAYGSQAPHNKM
S544	VNTMPHTSAMNRLTP
T550	TSAMNRLTPVKTPLQ
T554	NRLTPVKTPLQVPLS
K591	MGVLHQEKLPSDLDG
T642	FPHSVKTTTHSWVSG
S645	SVKTTTHSWVSG___
S648	TTTHSWVSG______

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