a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; DNA binding; protein phosphatase 2A binding; sequence-specific DNA binding; ubiquitin protein ligase binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; blood vessel development; transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; glucose homeostasis; negative regulation of stress-activated MAPK cascade; cellular response to starvation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; cellular response to insulin stimulus; positive regulation of protein catabolic process; insulin receptor signaling pathway; autophagy; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; response to DNA damage stimulus; positive regulation of autophagy; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.