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Protein Page:
SRCAP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SRCAP Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Acetyltransferase; Helicase; EC 3.6.1.-; Transcription, coactivator/corepressor; EC 3.6.4.-
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: Golgi apparatus; protein complex; nucleus
Molecular Function: histone acetyltransferase activity; DNA binding; transcription coactivator activity; helicase activity; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; histone acetylation
Reference #:  Q6ZRS2 (UniProtKB)
Alt. Names/Synonyms: domino homolog 1; Domino homolog 2; DOMO1; EAF1; FLJ44499; Helicase SRCAP; KIAA0309; Snf2-related CBP activator; Snf2-related CBP activator protein; Snf2-related CREBBP activator protein; SRCAP; Swi2/Snf2-related ATPase homolog, domino homolog 1; SWR1
Gene Symbols: SRCAP
Molecular weight: 343,555 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs
Select Structure to View Below

SRCAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S248-p EKYSDLLsQsLNQPL
0 3 S250-p YSDLLsQsLNQPLTS
0 2 S258-p LNQPLTSsKAGssPC
0 1 S262-p LTSsKAGssPCLGSS
0 3 S263-p TSsKAGssPCLGSSs
0 1 S269 ssPCLGSSsAASsPP
0 2 S270-p sPCLGSSsAASsPPP
0 1 S273 LGSSsAASsPPPPAS
0 4 S274-p GSSsAASsPPPPASR
0 2 T404-p DEDDEEFtANEEEAE
0 5 S562-p LARDEEQsEADAGsG
0 13 S568-p QsEADAGsGPPtPGP
0 13 T572-p DAGsGPPtPGPttLG
0 1 T576-p GPPtPGPttLGPKKE
0 1 T577-p PPtPGPttLGPKKEI
0 2 K752-ub LDEAQNIkNFKSQRW
0 4 K847-ac RVKVDVEkQMPKKYE
0 1 R866 CRLSKRQRCLYDDFM
0 1 T979-p RVLLEVAtAPDPPPR
0 1 T1008 VPKQEGRTVVVVNNP
0 1 N1014 RTVVVVNNPRAPLGP
0 4 S1172-p APQRLILsPDMQARL
0 1 S1186-p LPSGEVVsIGQLAsL
0 1 S1192-p VsIGQLAsLAQRPVA
0 1 K1205-ac VANAGGSkPLTFQIQ
0 1 R1224 TLTGAQVRQLAVGQP
0 2 R1224-m2 TLTGAQVrQLAVGQP
0 1 R1232-m2 QLAVGQPrPLQRNVV
0 1 S1826-p QASSLVVsAsGAAPL
0 1 S1828-p SSLVVsAsGAAPLPV
0 2 S1855-p PDTLTLRsGPPsPPS
0 5 S1859-p TLRsGPPsPPSTATS
0 3 S1882-p QPPPPPRsPFYLDSL
0 2 S1940-p ASPIGPRsPGPSHPT
0 1 T2258-p EEDIRAAtQAKAEQV
0 1 D2275-ca LAEFNENdGFPAGEG
0 1 T2374-p GDESSCGtGGGTHRR
0 1 T2406-p LRGARAEtQGANHtP
0 1 T2412-p EtQGANHtPVIsAHQ
0 1 S2416-gl ANHtPVIsAHQTRST
0 1 S2416-ga ANHtPVIsAHQTRST
0 1 T2424-p AHQTRSTttPPRCsP
0 3 T2425-p HQTRSTttPPRCsPA
0 19 S2430-p TttPPRCsPARERVP
0 1 T2682-p EELTEAKtPTSSPEK
0 1 T2724-p ARPPRRRtsADVEIR
0 3 S2725-p RPPRRRtsADVEIRG
0 6 S2787-p GVSETSAsPGsPSVR
0 8 S2790-p ETSAsPGsPSVRSMS
0 1 T2836-p RHIELGVtGGGsPEN
0 2 G2837 HIELGVtGGGsPENG
0 7 S2840-p LGVtGGGsPENGDGA
0 7 T2852-p DGALLAItPPAVKRR
0 13 S2869-p RPPKKNRsPADAGRG
0 3 S2956 PIPGTISSAGDGNSE
0 12 S3016-p RPPKNPPsPRPSQLP
0 1 S3020 NPPsPRPSQLPVLDR
0 1 S3031 VLDRDSTSVLESCGL
0 2 S3050-p QPQGQGEsEGsssDE
0 3 S3053-p GQGEsEGsssDEDGS
0 3 S3054-p QGEsEGsssDEDGSR
0 3 S3055-p GEsEGsssDEDGSRP
0 1 T3107-p GPGGLELtPPVVSLt
0 1 T3114-p tPPVVSLtPKLRSTR
0 7 S3126-p STRLRPGsLVPPLET
0 15 S3148-p AGAPVGGsPGLAKRG
0 6 S3161-p RGRLQPPsPLGPEGs
0 3 S3168-p sPLGPEGsVEEsEAE
0 2 S3172-p PEGsVEEsEAEAsGE
0 5 S3177-p EEsEAEAsGEEEEGD
  mouse

 
S248 EKYSDLLSQSLNQPP
S250 YSDLLSQSLNQPPAS
S258 LNQPPASSKAGssPC
S262-p PASSKAGssPCLGSs
S263-p ASSKAGssPCLGSss
S269-p ssPCLGSssAAssPP
S270-p sPCLGSssAAssPPP
S273-p LGSssAAssPPPPVS
S274-p GSssAAssPPPPVSR
T403-p DEDDEEFtANEDEAE
S573-p LARDDERsEVDGGsG
S579-p RsEVDGGsGPPtPGP
T583-p DGGsGPPtPGPTTTL
T587 GPPtPGPTTTLGPKK
T588 PPtPGPTTTLGPKKE
K764 LDEAQNIKNFKSQRW
K859-ac RVKVDVEkQMPKKYE
R878 CRLSKRQRCLYDDFM
T991 RILLEIATAPDPPPR
T1020 VPKQEGRTVVVVNSP
S1026 RTVVVVNSPRPPLGP
S1184 TPQRLILSPEMQARL
S1198 LPSGEVVSIGQLASL
S1204 VSIGQLASLAQRPVT
K1217 VTSAGGSKPLTFQIQ
R1236-m1 TLTGAQVrQLAVGQP
R1236 TLTGAQVRQLAVGQP
R1244 QLAVGQPRPLQRNVV
S1826 SQASSLVSASGAASL
S1828 ASSLVSASGAASLPV
S1855-p PETLTLRsGPPsPLP
S1859-p TLRsGPPsPLPTATS
S1882-p QPPPPPRsPFYLDSL
S1940-p ASPIGPRsPGPSHPI
T2258 EEDIRAATQAKAEQV
D2275 LAEFNENDGFPAGEG
S2376 GDEMSCGSSGASHRR
T2408 LRGARAETQGANHTP
T2414 ETQGANHTPVTSSHH
S2418 ANHTPVTSSHHTCNT
S2418 ANHTPVTSSHHTCNT
F2426 SHHTCNTFVPPQCSP
V2427 HHTCNTFVPPQCSPV
S2432 TFVPPQCSPVRERIP
I2694 GETREVQIPISNSEK
T2736 ARPPRRRTSADVEIR
S2737 RPPRRRTSADVEIRG
S2798-p GVSEVSAsPRSPSIH
S2801 EVSAsPRSPSIHSMS
T2847 RHNELGTTtGGsPEN
T2848-p HNELGTTtGGsPENG
S2851-p LGTTtGGsPENGEGT
T2863-p EGTELAItPPAVKRR
S2880-p RPPKKNRsPADAGRG
S2968-p PIPGTISsPGGGNLE
S3024-p RPPKNPPsPRPsQHP
S3028-p NPPsPRPsQHPVLDP
S3039-p VLDPDSSsILESCGL
S3058-p QPLGQAEsEGsssDE
S3061-p GQAEsEGsssDEDGS
S3062-p QAEsEGsssDEDGSR
S3063-p AEsEGsssDEDGSRP
T3115 GPSGLELTPPVVSLT
T3122 TPPVVSLTPKFRSTR
S3134 STRLRPGSLVPPLET
S3155 RSGAPVGSSGMAKRG
S3168-p RGRLQPPsPLGPEGs
S3175-p sPLGPEGsVEESEVE
S3179 PEGsVEESEVEAsGD
S3184-p EESEVEAsGDEEEGD
  rat

 
S248 EKYSDLLSQSLNQPL
S250 YSDLLSQSLNQPLAS
S258 LNQPLASSKAGSSPC
S262 LASSKAGSSPCLGSS
S263 ASSKAGSSPCLGSSS
S269 SSPCLGSSSAASSPP
S270 SPCLGSSSAASSPPP
S273 LGSSSAASSPPPPVS
S274 GSSSAASSPPPPVSR
T403 DEDDEEFTANEDEAE
S569-p LARDDERsEVDGGsG
S575-p RsEVDGGsGPPtPGP
T579-p DGGsGPPtPGPTTTL
T584 PPtPGPTTTLGPKKE
T585 PtPGPTTTLGPKKEI
K760 LDEAQNIKNFKSQRW
K855 RVKVDVEKQMPKKYE
R874-m1 CRLSKRQrCLYDDFM
T987 RILLEIATAPDPPPR
T1016-p VPKQEGRtVVVVNsP
S1022-p RtVVVVNsPRAPLGP
S1180 TPQRLILSPEMQARL
S1194 LPSGEVVSIGQLASL
S1200 VSIGQLASLAQRPVT
K1213 VTSAGGSKPLTFQIQ
R1232 TLTGAQVRQLAVGQP
R1232 TLTGAQVRQLAVGQP
R1240 QLAVGQPRPLQRNVV
S1817 SQASSLVSASGAASL
S1819 ASSLVSASGAASLPV
S1846 PETLTLRSGPPSPLP
S1850 TLRSGPPSPLPTATS
S1873 QPPPPPRSPFYLDSL
S1931 ASPIGPRSPGPSHPI
T2249 EEDIRAATQAKAEQV
E2266 LAEFNENEGFPAGEG
T2367 GDEMSCATSGVSHRR
T2399 LRGARAETQGANHTP
T2405 ETQGANHTPVTSSHQ
S2409 ANHTPVTSSHQTCNT
S2409 ANHTPVTSSHQTCNT
F2417 SHQTCNTFVPPRCSP
V2418 HQTCNTFVPPRCSPV
S2423 TFVPPRCSPVRERIP
- under review  
T2715 ARPPRRRTSADVEIR
S2716 RPPRRRTSADVEIRG
S2777 GVSEVSASPRSPSIH
S2780 EVSASPRSPSIHSMS
T2826 RHNELGITGGGsPEN
G2827 HNELGITGGGsPENG
S2830-p LGITGGGsPENGEGA
T2842-p EGAKLAItPPAVKRR
S2859 RPPKKNRSPADAGRG
S2943 PIPGTISSPGDGNLE
S2999 RPPKNPPSPRPSQHP
S3003 NPPSPRPSQHPVLDP
S3014 VLDPDSSSVLESCGL
S3033 QPLGQAESEGSSSDE
S3036 GQAESEGSSSDEDGS
S3037 QAESEGSSSDEDGSR
S3038 AESEGSSSDEDGSRP
T3090 GPSGLELTPPVVSLT
T3097 TPPVVSLTPKFRSTR
S3109 STRLRPGSLVPPLET
S3130 RSGAPVGSSGMAKRG
S3143 RGRLQPPSPLGPEGS
S3150 SPLGPEGSVEESEAE
S3154 PEGSVEESEAEASGD
S3159 EESEAEASGDEEEGD
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