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TMEM173
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Mitochondrial; Membrane protein, integral; Apoptosis |
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Cellular Component: mitochondrial outer membrane; endoplasmic reticulum membrane; perinuclear region of cytoplasm; integral to membrane; plasma membrane
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Molecular Function: protein binding; protein homodimerization activity; ubiquitin protein ligase binding; transcription factor binding; protein kinase binding
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Biological Process: positive regulation of protein import into nucleus, translocation; positive regulation of protein binding; apoptosis; positive regulation of transcription factor import into nucleus; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; activation of innate immune response; defense response to virus; interferon-beta production
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Reference #:
Q86WV6 (UniProtKB)
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| Alt. Names/Synonyms: endoplasmic reticulum IFN stimulator; ERIS; FLJ38577; hMITA; hSTING; Mediator of IRF3 activation; MITA; mitochondrial mediator of IRF3 activation; MPYS; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; NET23; Stimulator of interferon genes protein; STING; TM173; TMEM173; Transmembrane protein 173 |
| Gene Symbols: TMEM173 |
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Molecular weight: 42,193 Da
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Basal Isoelectric point: 6.6
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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