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Protein Page:
TTK (frog)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TTK a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, dual-specificity (non-receptor); Cancer Testis Antigen (CTA); EC 2.7.12.1; Kinase, protein; Protein kinase, Other; Other group; TTK family
Reference #:  AAK27843 (GenPept)
Alt. Names/Synonyms: CT96; LOC398219; Mps1
Molecular weight: 99,079 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Select Structure to View Below

TTK

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       frog

 
0 1 D3 _____MDDEDISERK
0 3 S7 _MDDEDISERKLKIA
2 1 K12 DISERKLKIASILDR
2 2 S15 ERKLKIASILDRVKS
0 1 R19 KIASILDRVKSFKTK
2 23 T34 YGTDDNWTDELTFSK
2 4 T38 DNWTDELTFSKSSAD
2 4 I80 ENTGLPQIDPQLLNK
0 4 K87 IDPQLLNKLIDNYSQ
0 1 Q132 DLDEAREQFQFARLN
0 1 K201 QLISDEDKENLAVSS
0 3 T215 SSHINQGTASFQNLA
0 1 S217 HINQGTASFQNLALG
0 1 Q219 NQGTASFQNLALGNP
0 1 G259 PEDFEDIGRKPLLNM
0 10 P262 FEDIGRKPLLNMSAK
1 15 S283 VPVQPATSPDTRTRK
4 0 S291 PDTRTRKSDGSGSSS
0 1 S294 RTRKSDGSGSSSVVK
0 2 A345 ILPHEEQANEDSLDM
0 5 S349 EEQANEDSLDMKTPS
0 1 S379 NEDLILGSTSTAVLN
0 1 - gap
2 2 - gap
1 0 - gap
2 2 S391 VLNPQENSKPSESAP
0 2 S396 ENSKPSESAPPLLPN
0 1 R407 LLPNINARLSDTTKP
0 68 - gap
0 2 - gap
0 1 - gap
0 1 - gap
0 5 - gap
0 4 - gap
0 1 - gap
2 13 S459 NPGSRRVSPPAPSLS
0 1 S464 RVSPPAPSLSKCDPV
1 11 T476 DPVFVCGTPVNKSQE
0 7 - gap
0 1 S481 CGTPVNKSQEDYMNC
0 59 Y485 VNKSQEDYMNCFRTP
0 1 N487 KSQEDYMNCFRTPVV
0 1 R490 EDYMNCFRTPVVKTN
1 4 T491 DYMNCFRTPVVKTNL
0 1 K559 IGTGGSSKVFQVMDD
0 1 K567 VFQVMDDKKHLYAIK
1 0 T585 LEEADQQTIESYQNE
1 0 - gap
0 1 T639 TWLRKKKTINPWERK
4 0 - gap
7 2 T697 NQIQPDVTSIVKDSQ
2 0 S698 QIQPDVTSIVKDSQV
6 1 T707 VKDSQVGTINYMPPE
0 1 R717 YMPPESIRDTTSYAE
1 0 - gap
1 0 - gap
1 0 T828 DQQVQKETTEEMKRI
1 0 T829 QQVQKETTEEMKRIL
0 6 K833 KETTEEMKRILGQLI
1 18 R834 ETTEEMKRILGQLIG
7 16 S844-p GQLIGLNsPNSISRA
1 1 S847 IGLNsPNSISRAAKN
0 1 R850 NsPNSISRAAKNLYD
0 62 Y856 SRAAKNLYDQFNSGR
0 66 - gap
0 1 - gap
1 0 - gap
1 0 - gap
0 1 - gap
1 0 T872 LDLSTLGTTVSQNTR
0 1 S875 STLGTTVSQNTRTTK
0 1 Q876 TLGTTVSQNTRTTK_
  human

 
S3-p _____MEsEDLsGRE
S7-p _MEsEDLsGRELtID
T12-p DLsGRELtIDsIMNk
S15-p GRELtIDsIMNkVRD
K19-m1 tIDsIMNkVRDIKNK
T33-p KFKNEDLtDELsLNK
S37-p EDLtDELsLNKISAD
S80-p EKNSVPLsDALLNkL
K86-ub LsDALLNkLIGRYSQ
Y131-p EPDDARDyFQMARAN
K200 QLLSEEEKKNLSAST
S214-p TVLTAQEsFsGsLGH
S216-p LTAQEsFsGsLGHLQ
S218-p AQEsFsGsLGHLQNR
Y255-p PQDAEIGyRNsLRQT
S258-p AEIGyRNsLRQTNKT
S281-p VPVNLLNsPDCDVKt
T288-p sPDCDVKtDDsVVPC
S291-p CDVKtDDsVVPCFMK
S317-p VVPGSKPsGNDsCEL
S321-p SKPsGNDsCELRNLK
T351-p KSSELIItDsITLKN
S353-p SELIItDsITLKNKt
T360-p sITLKNKtEssLLAK
S362-p TLKNKtEssLLAKLE
S363-p LKNKtEssLLAKLEE
T371-p LLAKLEEtkEyQEPE
K372-ub LAKLEEtkEyQEPEV
Y374-p KLEEtkEyQEPEVPE
S382-p QEPEVPEsNQkQWQS
K385-m1 EVPEsNQkQWQSKRK
K385-ub EVPEsNQkQWQSKRK
S393-p QWQSKRKsECINQNP
- gap
S433-p EQPVFSVsKQsPPIs
S436-p VFSVsKQsPPIsTSK
S440-p sKQsPPIsTSKWFDP
T453-p DPKSICKtPsSNtLD
S455-p KSICKtPsSNtLDDy
T458-p CKtPsSNtLDDyMsC
Y462-p sSNtLDDyMsCFrtP
S464-p NtLDDyMsCFrtPVV
R467-m2 DDyMsCFrtPVVKND
T468-p DyMsCFrtPVVKNDF
K538-ub IGSGGSSkVFQVLNE
K546-ub VFQVLNEkKQIYAIK
T564-p LEEADNQtLDSYRNE
S582-p LNKLQQHsDKIIRLY
S618-p SWLKKKKsIDPWERK
T675-p ANQMQPDttsVVKDS
T676-p NQMQPDttsVVKDSQ
S677-p QMQPDttsVVKDSQV
T686-p VKDSQVGtVNYMPPE
K696-ub YMPPEAIkDMSSSRE
S742-p QQIINQIsKLHAIID
T795-p HPYVQIQtHPVNQMA
T805-p VNQMAKGttEEMkyV
T806-p NQMAKGttEEMkyVL
K810-ub KGttEEMkyVLGQLV
Y811-p GttEEMkyVLGQLVG
S821-p GQLVGLNsPNsILkA
S824-p VGLNsPNsILkAAKT
K827-ub NsPNsILkAAKTLyE
Y833-p LkAAKTLyEHysGGE
Y836-p AKTLyEHysGGESHN
S837-p KTLyEHysGGESHNS
S845-p GGESHNSsSsktFEk
S847-p ESHNSsSsktFEkkR
K848-ub SHNSsSsktFEkkRG
T849-p HNSsSsktFEkkRGK
K852-ac sSsktFEkkRGKK__
K853-ac SsktFEkkRGKK___
  mouse

► Hide Isoforms
 
A3 _____MEAEELIGSS
I7 _MEAEELIGSSVTID
T12 ELIGSSVTIDSIMSK
S15 GSSVTIDSIMSKMRD
K19 TIDSIMSKMRDIKNK
T32-p NKINEDCtDELSLSK
S36 EDCtDELSLSKICAD
N76 EKNSSPLNDDLLNKL
K82 LNDDLLNKLIGRYSQ
Y127 EPDDARDYFQMAREN
K196-ac QLLPEEDkKSVSAST
P210 TVLSAQEPFSSSLGN
S212 LSAQEPFSSSLGNVQ
S214 AQEPFSSSLGNVQNR
H251 PQDAEVRHQNPFKQT
P254 AEVRHQNPFKQTHAA
S277-p VPVNLLNsPDFYVKT
T284 sPDFYVKTDSSAVTQ
S287 FYVKTDSSAVTQLTT
R338 ILPGSRPRGSDSYEL
S342 SRPRGSDSYELRGLK
S371 EKSSELMSDLIALKS
- gap
T380 LIALKSKTDSSLTKL
S382 ALKSKTDSSLTKLEE
S383 LKSKTDSSLTKLEET
T390 SLTKLEETKPEIAER
K391 LTKLEETKPEIAERR
- gap
- gap
- gap
- gap
- gap
T428-p LRHVPDVtPKADKES
- gap
S435 tPKADKESPPISVPK
S439 DKESPPISVPKWLDP
T452 DPKSACETPSSSSLD
S454 KSACETPSSSSLDDY
S457 CETPSSSSLDDYMKC
Y461 SSSSLDDYMKCFKTP
K463 SSLDDYMKCFKTPVV
K466 DDYMKCFKTPVVKND
T467 DYMKCFKTPVVKNDF
K537 IGSGGSSKVFQVLNE
K545 VFQVLNEKKQINAIK
T563 LEDADSQTIESYRNE
S581 LNKLQQHSDKIIRLY
S617 SWLKKKKSINPWERK
T674 ANQMQPDTTSIVKDS
T675 NQMQPDTTSIVKDSQ
S676 QMQPDTTSIVKDSQV
T685 VKDSQVGTVNYMAPE
R695 YMAPEAIRDMSSSRE
S741 QHIINQVSKLHAIIN
- gap
- gap
T805 SQMARGATDEMkYVL
K809-ub RGATDEMkYVLGQLV
Y810 GATDEMkYVLGQLVG
S820-p GQLVGLNsPNSILKT
S823 VGLNsPNSILKTAKT
K826 NsPNSILKTAKTLYE
Y832 LKTAKTLYERYNCGE
Y835 AKTLYERYNCGEGQD
- gap
S844 CGEGQDSSSSKTFDK
S846 EGQDSSSSKTFDKKR
K847 GQDSSSSKTFDKKRE
T848 QDSSSSKTFDKKRER
K851 SSSKTFDKKRERK__
K852 SSKTFDKKRERK___
  TTK iso2  
A3 _____MEAEELIGSS
I7 _MEAEELIGSSVTID
T12 ELIGSSVTIDSIMSK
S15 GSSVTIDSIMSKMRD
K19 TIDSIMSKMRDIKNK
T32 NKINEDCTDELSLSK
S36 EDCTDELSLSKICAD
N76 EKNSSPLNDDLLNKL
K82 LNDDLLNKLIGRYSQ
Y127 EPDDARDYFQMAREN
K196 QLLPEEDKKSVSAST
P210 TVLSAQEPFSSSLGN
S212 LSAQEPFSSSLGNVQ
S214 AQEPFSSSLGNVQNR
H251 PQDAEVRHQNPFKQT
P254 AEVRHQNPFKQTHAA
S277 VPVNLLNSPDFYVKT
T284 SPDFYVKTDSSAVTQ
S287 FYVKTDSSAVTQLTT
R312 ILPGSRPRGSDSYEL
S316 SRPRGSDSYELRGLK
S345 EKSSELMSDLIALKS
- gap
T354 LIALKSKTDSSLTKL
S356 ALKSKTDSSLTKLEE
S357 LKSKTDSSLTKLEET
T364 SLTKLEETKPEIAER
K365 LTKLEETKPEIAERR
- gap
- gap
- gap
- gap
- gap
T402 LRHVPDVTPKADKES
- gap
S409 TPKADKESPPISVPK
S413 DKESPPISVPKWLDP
T426 DPKSACETPSSSSLD
S428 KSACETPSSSSLDDY
S431 CETPSSSSLDDYMKC
Y435 SSSSLDDYMKCFKTP
K437 SSLDDYMKCFKTPVV
K440 DDYMKCFKTPVVKND
T441 DYMKCFKTPVVKNDF
K511 IGSGGSSKVFQVLNE
K519 VFQVLNEKKQINAIK
T537 LEDADSQTIESYRNE
S555 LNKLQQHSDKIIRLY
S591 SWLKKKKSINPWERK
T648 ANQMQPDTTSIVKDS
T649 NQMQPDTTSIVKDSQ
S650 QMQPDTTSIVKDSQV
T659 VKDSQVGTVNYMAPE
R669 YMAPEAIRDMSSSRE
S715 QHIINQVSKLHAIIN
- gap
- gap
T779 SQMARGATDEMKYVL
K783 RGATDEMKYVLGQLV
Y784 GATDEMKYVLGQLVG
S794-p GQLVGLNsPNSILKT
S797 VGLNsPNSILKTAKV
K800 NsPNSILKTAKVSAC
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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