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Protein Page:
TTK (frog)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TTK a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, dual-specificity (non-receptor); Protein kinase, Other; EC 2.7.12.1; Kinase, protein; Cancer Testis Antigen (CTA); Other group; TTK family
Reference #:  AAK27843 (GenPept)
Alt. Names/Synonyms: CT96; LOC398219; Mps1
Molecular weight: 99,079 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Select Structure to View Below

TTK

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       frog

 
0 1 D3 _____MDDEDISERK
0 3 S7 _MDDEDISERKLKIA
2 1 K12 DISERKLKIASILDR
2 2 S15 ERKLKIASILDRVKS
0 1 R19 KIASILDRVKSFKTK
2 15 T34 YGTDDNWTDELTFSK
2 3 T38 DNWTDELTFSKSSAD
2 4 I80 ENTGLPQIDPQLLNK
0 4 K87 IDPQLLNKLIDNYSQ
0 3 T215 SSHINQGTASFQNLA
0 1 S217 HINQGTASFQNLALG
0 1 Q219 NQGTASFQNLALGNP
0 11 P262 FEDIGRKPLLNMSAK
1 14 S283 VPVQPATSPDTRTRK
2 0 S291 PDTRTRKSDGSGSSS
0 1 A345 ILPHEEQANEDSLDM
0 4 S349 EEQANEDSLDMKTPS
0 1 S379 NEDLILGSTSTAVLN
0 1 - gap
2 1 - gap
1 0 - gap
2 1 S391 VLNPQENSKPSESAP
0 2 S396 ENSKPSESAPPLLPN
0 1 R407 LLPNINARLSDTTKP
0 83 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 5 - gap
0 4 - gap
2 11 S459 NPGSRRVSPPAPSLS
1 10 T476 DPVFVCGTPVNKSQE
0 6 - gap
0 61 Y485 VNKSQEDYMNCFRTP
0 1 R490 EDYMNCFRTPVVKTN
1 3 T491 DYMNCFRTPVVKTNL
0 1 K559 IGTGGSSKVFQVMDD
0 1 K567 VFQVMDDKKHLYAIK
1 0 T585 LEEADQQTIESYQNE
1 0 - gap
4 0 - gap
7 2 T697 NQIQPDVTSIVKDSQ
2 0 S698 QIQPDVTSIVKDSQV
6 1 T707 VKDSQVGTINYMPPE
0 1 R717 YMPPESIRDTTSYAE
1 0 - gap
1 0 - gap
1 0 T828 DQQVQKETTEEMKRI
1 0 T829 QQVQKETTEEMKRIL
0 6 K833 KETTEEMKRILGQLI
1 7 R834 ETTEEMKRILGQLIG
7 15 S844-p GQLIGLNsPNSISRA
1 0 S847 IGLNsPNSISRAAKN
0 1 R850 NsPNSISRAAKNLYD
0 75 Y856 SRAAKNLYDQFNSGR
0 84 - gap
1 0 - gap
1 0 - gap
0 1 - gap
1 0 T872 LDLSTLGTTVSQNTR
  human

 
S3-p _____MEsEDLsGRE
S7-p _MEsEDLsGRELtID
T12-p DLsGRELtIDsIMNk
S15-p GRELtIDsIMNkVRD
K19-m1 tIDsIMNkVRDIKNK
T33-p KFKNEDLtDELsLNK
S37-p EDLtDELsLNKISAD
S80-p EKNSVPLsDALLNkL
K86-u LsDALLNkLIGRYSQ
S214-p TVLTAQEsFsGsLGH
S216-p LTAQEsFsGsLGHLQ
S218-p AQEsFsGsLGHLQNR
S258-p AEIGYRNsLRQTNKT
S281-p VPVNLLNsPDCDVKt
T288-p sPDCDVKtDDSVVPC
S317-p VVPGSKPsGNDsCEL
S321-p SKPsGNDsCELRNLK
T351-p KSSELIItDsITLKN
S353-p SELIItDsITLKNKt
T360-p sITLKNKtEssLLAK
S362-p TLKNKtEssLLAKLE
S363-p LKNKtEssLLAKLEE
T371-p LLAKLEEtkEyQEPE
K372-u LAKLEEtkEyQEPEV
Y374-p KLEEtkEyQEPEVPE
S382-p QEPEVPEsNQkQWQS
K385-m1 EVPEsNQkQWQSKRK
K385-u EVPEsNQkQWQSKRK
S393-p QWQSKRKsECINQNP
- gap
S436-p VFSVSKQsPPISTSK
T453-p DPKSICKtPsSNTLD
S455-p KSICKtPsSNTLDDy
Y462-p sSNTLDDyMSCFrtP
R467-m2 DDyMSCFrtPVVKND
T468-p DyMSCFrtPVVKNDF
K538-u IGSGGSSkVFQVLNE
K546-u VFQVLNEkKQIYAIK
T564-p LEEADNQtLDSYRNE
S582-p LNKLQQHsDKIIRLY
T675-p ANQMQPDttsVVKDS
T676-p NQMQPDttsVVKDSQ
S677-p QMQPDttsVVKDSQV
T686-p VKDSQVGtVNYMPPE
K696-u YMPPEAIkDMSSSRE
S742-p QQIINQIsKLHAIID
T795-p HPYVQIQtHPVNQMA
T805-p VNQMAKGttEEMkyV
T806-p NQMAKGttEEMkyVL
K810-u KGttEEMkyVLGQLV
Y811-p GttEEMkyVLGQLVG
S821-p GQLVGLNsPNsILkA
S824-p VGLNsPNsILkAAKT
K827-u NsPNsILkAAKTLyE
Y833-p LkAAKTLyEHySGGE
Y836-p AKTLyEHySGGESHN
S845-p GGESHNSsSsktFEK
S847-p ESHNSsSsktFEKKR
K848-u SHNSsSsktFEKKRG
T849-p HNSsSsktFEKKRGK
  mouse

► Hide Isoforms
 
A3 _____MEAEELIGSS
I7 _MEAEELIGSSVTID
T12 ELIGSSVTIDSIMSK
S15 GSSVTIDSIMSKMRD
K19 TIDSIMSKMRDIKNK
T32-p NKINEDCtDELSLSK
S36 EDCtDELSLSKICAD
N76 EKNSSPLNDDLLNKL
K82 LNDDLLNKLIGRYSQ
P210 TVLSAQEPFSSSLGN
S212 LSAQEPFSSSLGNVQ
S214 AQEPFSSSLGNVQNR
P254 AEVRHQNPFKQTHAA
S277-p VPVNLLNsPDFYVKT
T284 sPDFYVKTDSSAVTQ
R338 ILPGSRPRGSDSYEL
S342 SRPRGSDSYELRGLK
S371 EKSSELMSDLIALKS
- gap
T380 LIALKSKTDSSLTKL
S382 ALKSKTDSSLTKLEE
S383 LKSKTDSSLTKLEET
T390 SLTKLEETKPEIAER
K391 LTKLEETKPEIAERR
- gap
- gap
- gap
- gap
- gap
T428-p LRHVPDVtPKADKES
S435 tPKADKESPPISVPK
T452 DPKSACETPSSSSLD
S454 KSACETPSSSSLDDY
Y461 SSSSLDDYMKCFKTP
K466 DDYMKCFKTPVVKND
T467 DYMKCFKTPVVKNDF
K537 IGSGGSSKVFQVLNE
K545 VFQVLNEKKQINAIK
T563 LEDADSQTIESYRNE
S581 LNKLQQHSDKIIRLY
T674 ANQMQPDTTSIVKDS
T675 NQMQPDTTSIVKDSQ
S676 QMQPDTTSIVKDSQV
T685 VKDSQVGTVNYMAPE
R695 YMAPEAIRDMSSSRE
S741 QHIINQVSKLHAIIN
- gap
- gap
T805 SQMARGATDEMkYVL
K809-u RGATDEMkYVLGQLV
Y810 GATDEMkYVLGQLVG
S820-p GQLVGLNsPNSILKT
S823 VGLNsPNSILKTAKT
K826 NsPNSILKTAKTLYE
Y832 LKTAKTLYERYNCGE
Y835 AKTLYERYNCGEGQD
S844 CGEGQDSSSSKTFDK
S846 EGQDSSSSKTFDKKR
K847 GQDSSSSKTFDKKRE
T848 QDSSSSKTFDKKRER
  TTK iso2  
A3 _____MEAEELIGSS
I7 _MEAEELIGSSVTID
T12 ELIGSSVTIDSIMSK
S15 GSSVTIDSIMSKMRD
K19 TIDSIMSKMRDIKNK
T32 NKINEDCTDELSLSK
S36 EDCTDELSLSKICAD
N76 EKNSSPLNDDLLNKL
K82 LNDDLLNKLIGRYSQ
P210 TVLSAQEPFSSSLGN
S212 LSAQEPFSSSLGNVQ
S214 AQEPFSSSLGNVQNR
P254 AEVRHQNPFKQTHAA
S277 VPVNLLNSPDFYVKT
T284 SPDFYVKTDSSAVTQ
R312 ILPGSRPRGSDSYEL
S316 SRPRGSDSYELRGLK
S345 EKSSELMSDLIALKS
- gap
T354 LIALKSKTDSSLTKL
S356 ALKSKTDSSLTKLEE
S357 LKSKTDSSLTKLEET
T364 SLTKLEETKPEIAER
K365 LTKLEETKPEIAERR
- gap
- gap
- gap
- gap
- gap
T402 LRHVPDVTPKADKES
S409 TPKADKESPPISVPK
T426 DPKSACETPSSSSLD
S428 KSACETPSSSSLDDY
Y435 SSSSLDDYMKCFKTP
K440 DDYMKCFKTPVVKND
T441 DYMKCFKTPVVKNDF
K511 IGSGGSSKVFQVLNE
K519 VFQVLNEKKQINAIK
T537 LEDADSQTIESYRNE
S555 LNKLQQHSDKIIRLY
T648 ANQMQPDTTSIVKDS
T649 NQMQPDTTSIVKDSQ
S650 QMQPDTTSIVKDSQV
T659 VKDSQVGTVNYMAPE
R669 YMAPEAIRDMSSSRE
S715 QHIINQVSKLHAIIN
- gap
- gap
T779 SQMARGATDEMKYVL
K783 RGATDEMKYVLGQLV
Y784 GATDEMKYVLGQLVG
S794-p GQLVGLNsPNSILKT
S797 VGLNsPNSILKTAKV
K800 NsPNSILKTAKVSAC
- gap
- gap
- gap
- gap
- gap
- gap
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