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TTK (frog)

Overview TTK a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint. Note: This description may include information from UniProtKB. Protein type: Protein kinase, dual-specificity; EC 2.7.12.1; Cancer Testis Antigen (CTA); Protein kinase, Other; Kinase, protein; Other group; TTK family Reference #:  AAK27843 (GenPept) Alt. Names/Synonyms: CT96; LOC398219; Mps1 Molecular weight: 99,079 Da Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states

Select Structure to View Below TTK 2X9E - A=514-828 (human) 2ZMC - A=510-857 (human) 2ZMD - A=510-857 (human) 3CEK - A=519-808 (human) 3DBQ - A=515-857 (human) 3GFW - A=519-808 (human) 3H9F - A=519-808 (human) 3HMN - A=510-809 (human) 3HMO - A=510-809 (human) 3HMP - A=510-809 (human) 3VQU - A=516-820 (human) 4H7X - A/B=55-210 (human) 4H7Y - A/D/C/B=55-210 (human) Substrate Sequence Logo

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			frog
0	1		D3	_____MDDEDISERK
0	2		S7	_MDDEDISERKLKIA
2	1		K12	DISERKLKIASILDR
2	2		S15	ERKLKIASILDRVKS
2	12		T34	YGTDDNWTDELTFSK
2	3		T38	DNWTDELTFSKSSAD
2	4		I80	ENTGLPQIDPQLLNK
0	4		K87	IDPQLLNKLIDNYSQ
0	1		Q132	DLDEAREQFQFARLN
0	1		K201	QLISDEDKENLAVSS
0	3		T215	SSHINQGTASFQNLA
0	1		S217	HINQGTASFQNLALG
0	1		Q219	NQGTASFQNLALGNP
0	1		G259	PEDFEDIGRKPLLNM
0	11		P262	FEDIGRKPLLNMSAK
1	12		S283	VPVQPATSPDTRTRK
2	0		S291	PDTRTRKSDGSGSSS
0	1		A345	ILPHEEQANEDSLDM
0	3		S349	EEQANEDSLDMKTPS
0	1		S379	NEDLILGSTSTAVLN
0	1		S381	DLILGSTSTAVLNPQ
2	1		Q388	STAVLNPQENSKPSE
1	0		N390	AVLNPQENSKPSESA
2	1		S391	VLNPQENSKPSESAP
0	2		S396	ENSKPSESAPPLLPN
0	1		A397	NSKPSESAPPLLPNI
0	83		P399	KPSESAPPLLPNINA
0	1		T412	NARLSDTTKPNNIEA
0	1		N415	LSDTTKPNNIEAEWK
0	1		N415	LSDTTKPNNIEAEWK
0	5		-	gap
0	4		-	gap
2	10		S459	NPGSRRVSPPAPSLS
1	10		T476	DPVFVCGTPVNKSQE
0	5		V478	VFVCGTPVNKSQEDY
0	1		S481	CGTPVNKSQEDYMNC
0	61		Y485	VNKSQEDYMNCFRTP
0	1		R490	EDYMNCFRTPVVKTN
1	3		T491	DYMNCFRTPVVKTNL
0	1		K559	IGTGGSSKVFQVMDD
0	1		K567	VFQVMDDKKHLYAIK
1	0		T585	LEEADQQTIESYQNE
1	0		C603	LNKLQQHCDKIIRLF
0	1		T639	TWLRKKKTINPWERK
4	0		V696	ANQIQPDVTSIVKDS
7	2		T697	NQIQPDVTSIVKDSQ
2	0		S698	QIQPDVTSIVKDSQV
6	1		T707	VKDSQVGTINYMPPE
0	1		R717	YMPPESIRDTTSYAE
1	0		A763	QHITNQIAKLHSILD
1	0		P816	HPYVQIQPHTQPDQQ
1	0		T828	DQQVQKETTEEMKRI
1	0		T829	QQVQKETTEEMKRIL
0	6		K833	KETTEEMKRILGQLI
1	7		R834	ETTEEMKRILGQLIG
7	14		S844-p	GQLIGLNsPNSISRA
1	0		S847	IGLNsPNSISRAAKN
0	1		R850	NsPNSISRAAKNLYD
0	75		Y856	SRAAKNLYDQFNSGR
0	84		F859	AKNLYDQFNSGRSLD
0	1		N860	KNLYDQFNSGRSLDL
1	0		S868	SGRSLDLSTLGTTVS
1	0		L870	RSLDLSTLGTTVSQN
0	1		G871	SLDLSTLGTTVSQNT
1	0		T872	LDLSTLGTTVSQNTR
0	1		S875	STLGTTVSQNTRTTK
0	1		Q876	TLGTTVSQNTRTTK_

	human
S3-p	_____MEsEDLsGRE
S7-p	_MEsEDLsGRELtID
T12-p	DLsGRELtIDsIMNK
S15-p	GRELtIDsIMNKVRD
T33-p	KFKNEDLtDELsLNK
S37-p	EDLtDELsLNKISAD
S80-p	EKNSVPLsDALLNkL
K86-u	LsDALLNkLIGRYSQ
Y131-p	EPDDARDyFQMARAN
K200	QLLSEEEKKNLSAST
S214-p	TVLTAQEsFsGsLGH
S216-p	LTAQEsFsGsLGHLQ
S218-p	AQEsFsGsLGHLQNR
Y255-p	PQDAEIGyRNsLRQT
S258-p	AEIGyRNsLRQTNKT
S281-p	VPVNLLNsPDCDVKt
T288-p	sPDCDVKtDDSVVPC
S317-p	VVPGSKPsGNDsCEL
S321-p	SKPsGNDsCELRNLK
T351-p	KSSELIItDsITLKN
S353-p	SELIItDsITLKNKt
T360-p	sITLKNKtEssLLAK
S362-p	TLKNKtEssLLAKLE
S363-p	LKNKtEssLLAKLEE
T371-p	LLAKLEEtkEyQEPE
K372-u	LAKLEEtkEyQEPEV
Y374-p	KLEEtkEyQEPEVPE
S382-p	QEPEVPEsNQkQWQS
K385-m1	EVPEsNQkQWQSKRK
K385-u	EVPEsNQkQWQSKRK
S393-p	QWQSKRKsECINQNP
-	gap
S436-p	VFSVSKQsPPISTSK
T453-p	DPKSICKtPsSNtLD
S455-p	KSICKtPsSNtLDDy
T458-p	CKtPsSNtLDDyMSC
Y462-p	sSNtLDDyMSCFrtP
R467-m2	DDyMSCFrtPVVKND
T468-p	DyMSCFrtPVVKNDF
K538-u	IGSGGSSkVFQVLNE
K546-u	VFQVLNEkKQIYAIK
T564-p	LEEADNQtLDSYRNE
S582-p	LNKLQQHsDKIIRLY
S618-p	SWLKKKKsIDPWERK
T675-p	ANQMQPDttsVVKDS
T676-p	NQMQPDttsVVKDSQ
S677-p	QMQPDttsVVKDSQV
T686-p	VKDSQVGtVNYMPPE
K696-u	YMPPEAIkDMSSSRE
S742-p	QQIINQIsKLHAIID
T795-p	HPYVQIQtHPVNQMA
T805-p	VNQMAKGttEEMkyV
T806-p	NQMAKGttEEMkyVL
K810-u	KGttEEMkyVLGQLV
Y811-p	GttEEMkyVLGQLVG
S821-p	GQLVGLNsPNsILkA
S824-p	VGLNsPNsILkAAKT
K827-u	NsPNsILkAAKTLyE
Y833-p	LkAAKTLyEHysGGE
Y836-p	AKTLyEHysGGESHN
S837-p	KTLyEHysGGESHNS
S845-p	GGESHNSsSsktFEk
S847-p	ESHNSsSsktFEkkR
K848-u	SHNSsSsktFEkkRG
T849-p	HNSsSsktFEkkRGK
K852-a	sSsktFEkkRGKK__
K853-a	SsktFEkkRGKK___

	mouse ► Hide Isoforms
A3	_____MEAEELIGSS
I7	_MEAEELIGSSVTID
T12	ELIGSSVTIDSIMSK
S15	GSSVTIDSIMSKMRD
T32-p	NKINEDCtDELSLSK
S36	EDCtDELSLSKICAD
N76	EKNSSPLNDDLLNKL
K82	LNDDLLNKLIGRYSQ
Y127	EPDDARDYFQMAREN
K196-a	QLLPEEDkKSVSAST
P210	TVLSAQEPFSSSLGN
S212	LSAQEPFSSSLGNVQ
S214	AQEPFSSSLGNVQNR
H251	PQDAEVRHQNPFKQT
P254	AEVRHQNPFKQTHAA
S277-p	VPVNLLNsPDFYVKT
T284	sPDFYVKTDSSAVTQ
R338	ILPGSRPRGSDSYEL
S342	SRPRGSDSYELRGLK
S371	EKSSELMSDLIALKS
L373	SSELMSDLIALKSKT
T380	LIALKSKTDSSLTKL
S382	ALKSKTDSSLTKLEE
S383	LKSKTDSSLTKLEET
T390	SLTKLEETKPEIAER
K391	LTKLEETKPEIAERR
-	gap
R397	TKPEIAERRPMQWQS
M400	EIAERRPMQWQSTRK
M400	EIAERRPMQWQSTRK
P408	QWQSTRKPECVFQNP
T428-p	LRHVPDVtPKADKES
S435	tPKADKESPPISVPK
T452	DPKSACETPSSSSLD
S454	KSACETPSSSSLDDY
S457	CETPSSSSLDDYMKC
Y461	SSSSLDDYMKCFKTP
K466	DDYMKCFKTPVVKND
T467	DYMKCFKTPVVKNDF
K537	IGSGGSSKVFQVLNE
K545	VFQVLNEKKQINAIK
T563	LEDADSQTIESYRNE
S581	LNKLQQHSDKIIRLY
S617	SWLKKKKSINPWERK
T674	ANQMQPDTTSIVKDS
T675	NQMQPDTTSIVKDSQ
S676	QMQPDTTSIVKDSQV
T685	VKDSQVGTVNYMAPE
R695	YMAPEAIRDMSSSRE
S741	QHIINQVSKLHAIIN
P794	HPYVQIQPHPGSQMA
A804	GSQMARGATDEMkYV
T805	SQMARGATDEMkYVL
K809-u	RGATDEMkYVLGQLV
Y810	GATDEMkYVLGQLVG
S820-p	GQLVGLNsPNSILKT
S823	VGLNsPNSILKTAKT
K826	NsPNSILKTAKTLYE
Y832	LKTAKTLYERYNCGE
Y835	AKTLYERYNCGEGQD
N836	KTLYERYNCGEGQDS
S844	CGEGQDSSSSKTFDK
S846	EGQDSSSSKTFDKKR
K847	GQDSSSSKTFDKKRE
T848	QDSSSSKTFDKKRER
K851	SSSKTFDKKRERK__
K852	SSKTFDKKRERK___

	TTK iso2
A3	_____MEAEELIGSS
I7	_MEAEELIGSSVTID
T12	ELIGSSVTIDSIMSK
S15	GSSVTIDSIMSKMRD
T32	NKINEDCTDELSLSK
S36	EDCTDELSLSKICAD
N76	EKNSSPLNDDLLNKL
K82	LNDDLLNKLIGRYSQ
Y127	EPDDARDYFQMAREN
K196	QLLPEEDKKSVSAST
P210	TVLSAQEPFSSSLGN
S212	LSAQEPFSSSLGNVQ
S214	AQEPFSSSLGNVQNR
H251	PQDAEVRHQNPFKQT
P254	AEVRHQNPFKQTHAA
S277	VPVNLLNSPDFYVKT
T284	SPDFYVKTDSSAVTQ
R312	ILPGSRPRGSDSYEL
S316	SRPRGSDSYELRGLK
S345	EKSSELMSDLIALKS
L347	SSELMSDLIALKSKT
T354	LIALKSKTDSSLTKL
S356	ALKSKTDSSLTKLEE
S357	LKSKTDSSLTKLEET
T364	SLTKLEETKPEIAER
K365	LTKLEETKPEIAERR
-	gap
R371	TKPEIAERRPMQWQS
M374	EIAERRPMQWQSTRK
M374	EIAERRPMQWQSTRK
P382	QWQSTRKPECVFQNP
T402	LRHVPDVTPKADKES
S409	TPKADKESPPISVPK
T426	DPKSACETPSSSSLD
S428	KSACETPSSSSLDDY
S431	CETPSSSSLDDYMKC
Y435	SSSSLDDYMKCFKTP
K440	DDYMKCFKTPVVKND
T441	DYMKCFKTPVVKNDF
K511	IGSGGSSKVFQVLNE
K519	VFQVLNEKKQINAIK
T537	LEDADSQTIESYRNE
S555	LNKLQQHSDKIIRLY
S591	SWLKKKKSINPWERK
T648	ANQMQPDTTSIVKDS
T649	NQMQPDTTSIVKDSQ
S650	QMQPDTTSIVKDSQV
T659	VKDSQVGTVNYMAPE
R669	YMAPEAIRDMSSSRE
S715	QHIINQVSKLHAIIN
P768	HPYVQIQPHPGSQMA
A778	GSQMARGATDEMKYV
T779	SQMARGATDEMKYVL
K783	RGATDEMKYVLGQLV
Y784	GATDEMKYVLGQLVG
S794-p	GQLVGLNsPNSILKT
S797	VGLNsPNSILKTAKV
K800	NsPNSILKTAKVSAC
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

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