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Protein Page:
FGFR3 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR3 a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with thanatophoric dysplasia (TD), craniosynostosis Adelaide type, many craniosynostotic syndromes and bone malformations. Three splice-variant isoforms have been described. Activating point mutations cause dwarfism, including achondroplasia, hypochrondroplasia and thanatophoric dysplasia, and facial and other morphogenetic disorders, including Crouzon syndrome, craniosynostosis Adelaide type, San Diego skeletal displasia and Muenke syndrome. Translocations t(4;14) involving the IgH region are common in multiple myeloma and frequently involve FGFR3. Activated FGFR3 found in 30% of bladder cancers and several cervical cancers, but not in other tumors. Two mutations found in colorectal cancer. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; Kinase, protein; TK group; FGFR family
Cellular Component: internal side of plasma membrane; cell surface; membrane; lysosome; endoplasmic reticulum; perinuclear region of cytoplasm; integral to plasma membrane; cytoplasm; plasma membrane; integral to membrane; cytoplasmic vesicle; nucleus
Molecular Function: transferase activity; protein binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity
Biological Process: peptidyl-tyrosine phosphorylation; somatic stem cell maintenance; apoptosis; protein amino acid autophosphorylation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; bone mineralization; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of cell proliferation; substantia nigra development; inner ear receptor cell differentiation; positive regulation of MAPKKK cascade; cell-cell signaling; positive regulation of neuron apoptosis; forebrain development; positive regulation of cell proliferation; morphogenesis of an epithelium; response to axon injury; cell differentiation; oligodendrocyte development; inner ear development; skeletal development; negative regulation of epithelial cell proliferation; negative regulation of developmental growth; fibroblast growth factor receptor signaling pathway; myelination in the central nervous system; MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; digestive tract morphogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein ubiquitination; negative regulation of smoothened signaling pathway; cartilage development; negative regulation of astrocyte differentiation; negative regulation of mitosis; positive regulation of endothelial cell proliferation; lens morphogenesis in camera-type eye; positive regulation of cell differentiation; phosphorylation
Reference #:  Q61851 (UniProtKB)
Alt. Names/Synonyms: FGFR-3; Fgfr3; Fibroblast growth factor receptor 3; HBGFR; Heparin-binding growth factor receptor; Mfr3; Sam3
Gene Symbols: Fgfr3
Molecular weight: 87,758 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Select Structure to View Below

FGFR3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S402 PPKKGLGSPTVHKVS
0 1 S418-p FPLKRQVsLESNSSM
0 1 S424 VsLESNSSMNSNTPL
0 1 T429 NSSMNSNTPLVRIAR
0 8 S438-p LVRIARLssGEGPVL
0 9 S439-p VRIARLssGEGPVLA
0 1 K524 VSEMEMMKMIGKHKN
0 2 Y546-p CTQGGPLyVLVEYAA
1 9 Y571 RRPPGMDYSFDACRL
0 1 S572 RPPGMDYSFDACRLP
0 12 Y593-p KDLVSCAyQVARGME
0 2 Y601 QVARGMEYLASQKCI
0 1 K626 VTEDNVMKIADFGLA
1 47 Y641-p RDVHNLDyyKKTTNG
1 18 Y642-p DVHNLDyyKKTTNGR
2 3 Y719 ASCTHDLYMIMRECW
2 0 Y755 TVTSTDEYLDLSVPF
1 0 Y765 LSVPFEQYSPGGQDT
0 2 T772 YSPGGQDTPSSSSSG
0 2 S782 SSSSGDDSVFTHDLL
  human

► Hide Isoforms
 
S408-p PPKKGLGsPTVHKIS
S424 FPLKRQVSLESNASM
S430 VSLESNASMSSNTPL
T435 NASMSSNTPLVRIAR
S444-p LVRIARLssGEGPTL
S445-p VRIARLssGEGPTLA
K530-ac VSEMEMMkMIGKHKN
Y552 CTQGGPLYVLVEYAA
Y577-p RRPPGLDysFDTCKP
S578-p RPPGLDysFDTCKPP
Y599-p KDLVSCAyQVARGME
Y607-p QVARGMEyLASQKCI
K632-ub VTEDNVMkIADFGLA
Y647-p RDVHNLDyyKKTTNG
Y648-p DVHNLDyyKKTTNGR
Y724-p ANCTHDLyMIMRECW
Y760-p TVTSTDEyLDLSAPF
Y770-p LSAPFEQySPGGQDt
T777-p ySPGGQDtPSSSSSG
S787-p SSSSGDDsVFAHDLL
  FGFR3 iso3  
- gap
S312 YVTVLKVSLESNAsM
S318-p VSLESNAsMSSNtPL
T323-p NAsMSSNtPLVRIAR
S332 LVRIARLSSGEGPTL
S333 VRIARLSSGEGPTLA
K418 VSEMEMMKMIGKHKN
Y440 CTQGGPLYVLVEYAA
Y465 RRPPGLDYSFDTCKP
S466 RPPGLDYSFDTCKPP
Y487 KDLVSCAYQVARGME
Y495 QVARGMEYLASQKCI
K520 VTEDNVMKIADFGLA
Y535 RDVHNLDYYKKTTNG
Y536 DVHNLDYYKKTTNGR
Y612 ANCTHDLYMIMRECW
Y648 TVTSTDEYLDLSAPF
Y658 LSAPFEQYSPGGQDT
T665 YSPGGQDTPSSSSSG
S675 SSSSGDDSVFAHDLL
  rat

 
S402 PPKKGLGSPTVHKVS
S418 FPLKRQVSLESNSSM
S424 VSLESNSSMNSNTPL
T429 NSSMNSNTPLVRIAR
S438 LVRIARLSSGEGPVL
S439 VRIARLSSGEGPVLA
K524 VSEMEMMKMIGKHKN
Y546 CTQGGPLYVLVEYAA
Y571 RRPPGMDYSFDACRL
S572 RPPGMDYSFDACRLP
Y593 KDLVSCAYQVARGME
Y601 QVARGMEYLASQKCI
K626 VTEDNVMKIADFGLA
Y641-p RDVHNLDyyKKTTNG
Y642-p DVHNLDyyKKTTNGR
Y718 ANCTHDLYMIMRECW
Y754 TVTSTDEYLDLSVPF
Y764 LSVPFEQYSPGGQDT
T771 YSPGGQDTPSSSSSG
S781 SSSSGDDSVFTHDLL
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