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Protein Page:
5-HT(1A) (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
5-HT(1A) This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; serotonin receptor activity
Biological Process: vasoconstriction; cell proliferation; G-protein coupled receptor protein signaling pathway; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of serotonin secretion; regulation of hormone secretion; serotonin receptor signaling pathway; serotonin metabolic process; regulation of behavior
Reference #:  P08908 (UniProtKB)
Alt. Names/Synonyms: 5-HT-1A; 5-HT1A; 5-HT1a receptor; 5-hydroxytryptamine (serotonin) receptor 1A; 5-hydroxytryptamine receptor 1A; 5HT1a; ADRB2RL1; ADRBRL1; G protein coupled receptor; G-21; guanine nucleotide-binding regulatory protein-coupled receptor; HTR1A; Serotonin receptor 1A
Gene Symbols: HTR1A
Molecular weight: 46,107 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

5-HT(1A)

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S66 AAIALERSLQNVANY
0 1 S86 AVTDLMVSVLVLPMA
2 0 T149 IDYVNKRTPRRAAAL
0 1 T177 PPMLGWRTPEDRSDP
0 1 T196-p ISKDHGYtIYsTFGA
0 1 S199-p DHGYtIYsTFGAFyI
0 2 Y205-p YsTFGAFyIPLLLML
0 1 Y215-p LLLMLVLyGRIFRAA
0 1 T240-p VEKTGADtRHGASPA
0 1 S301 EVHRVGNSKEHLPLP
0 1 K324-ac APASFERkNERNAEA
0 1 K334-ub RNAEAKRkMALARER
  mouse

 
S66-p AAIALERsLQNVANY
S86-p AVTDLMVsVLVLPMA
T149 IDYVNKRTPRRAAAL
T177 PPMLGWRTPEDRSNP
T196 ISKDHGYTIYSTFGA
S199 DHGYTIYSTFGAFYI
Y205 YSTFGAFYIPLLLML
Y215 LLLMLVLYGRIFRAA
T240 VEKKGAGTSFGTSSA
S301 EVHRVGNSKGHLPLP
K324 VPACLERKNERTAEA
K334 RTAEAKRKMALARER
  rat

 
S66 AAIALERSLQNVANY
S86 AVTDLMVSVLVLPMA
T149-p IDYVNKRtPRRAAAL
T177-p PPMLGWRtPEDRSDP
T196 ISKDHGYTIYSTFGA
S199 DHGYTIYSTFGAFYI
Y205 YSTFGAFYIPLLLML
Y215 LLLMLVLYGRIFRAA
T240 VEKKGAGTSLGTSSA
S301-p EVHRVGNsKEHLPLP
K324 APACLERKNERNAEA
K334 RNAEAKRKMALARER
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