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5-HT(1A) (human)

Overview 5-HT(1A) This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR Cellular Component: axon hillock; integral to plasma membrane; plasma membrane Molecular Function: serotonin binding; serotonin receptor activity; drug binding Biological Process: G-protein coupled receptor protein signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; behavior; positive regulation of cell proliferation Reference #:  P08908 (UniProtKB) Alt. Names/Synonyms: 5-HT-1A; 5-HT1A; 5-HT1a receptor; 5-hydroxytryptamine (serotonin) receptor 1A; 5-hydroxytryptamine receptor 1A; 5HT1a; ADRB2RL1; ADRBRL1; G protein coupled receptor; G-21; guanine nucleotide-binding regulatory protein-coupled receptor; HTR1A; Serotonin receptor 1A Gene Symbols: HTR1A Molecular weight: 46,107 Da Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below 5-HT(1A)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S66	AAIALERSLQNVANY
0	1		S86	AVTDLMVSVLVLPMA
2	0		T149	IDYVNKRTPRRAAAL
0	1		T177	PPMLGWRTPEDRSDP
0	1		T196-p	ISKDHGYtIYsTFGA
0	1		S199-p	DHGYtIYsTFGAFyI
0	2		Y205-p	YsTFGAFyIPLLLML
0	1		Y215-p	LLLMLVLyGRIFRAA
0	1		T240-p	VEKTGADtRHGASPA
0	1		S301	EVHRVGNSKEHLPLP
0	1		C316	SEAGPTPCAPASFER
0	1		K324-a	APASFERkNERNAEA
0	1		K334-u	RNAEAKRkMALARER

	mouse
S66-p	AAIALERsLQNVANY
S86-p	AVTDLMVsVLVLPMA
T149	IDYVNKRTPRRAAAL
T177	PPMLGWRTPEDRSNP
T196	ISKDHGYTIYSTFGA
S199	DHGYTIYSTFGAFYI
Y205	YSTFGAFYIPLLLML
Y215	LLLMLVLYGRIFRAA
T240	VEKKGAGTSFGTSSA
S301	EVHRVGNSKGHLPLP
Y316	SESGATSYVPACLER
K324	VPACLERKNERTAEA
K334	RTAEAKRKMALARER

	rat
S66	AAIALERSLQNVANY
S86	AVTDLMVSVLVLPMA
T149-p	IDYVNKRtPRRAAAL
T177-p	PPMLGWRtPEDRSDP
T196	ISKDHGYTIYSTFGA
S199	DHGYTIYSTFGAFYI
Y205	YSTFGAFYIPLLLML
Y215	LLLMLVLYGRIFRAA
T240	VEKKGAGTSLGTSSA
S301-p	EVHRVGNsKEHLPLP
Y316-p	SESGSNSyAPACLER
K324	APACLERKNERNAEA
K334	RNAEAKRKMALARER

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