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Protein Page:
DRD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DRD2 Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Cellular Component: synaptic vesicle membrane; axon; endocytic vesicle; integral to plasma membrane; dendrite; postsynaptic density; acrosome; dendritic spine; plasma membrane; perikaryon; nerve terminal; lateral plasma membrane
Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein homodimerization activity; potassium channel regulator activity; protein heterodimerization activity; dopamine binding; drug binding
Biological Process: response to nicotine; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); prepulse inhibition; positive regulation of dopamine uptake; response to toxin; positive regulation of receptor internalization; regulation of phosphoprotein phosphatase activity; positive regulation of multicellular organism growth; thermoregulation; adult walking behavior; dopamine metabolic process; negative regulation of insulin secretion; dopamine receptor, adenylate cyclase inhibiting pathway; protein localization; phosphatidylinositol metabolic process; negative regulation of blood pressure; response to drug; response to light stimulus; positive regulation of neuroblast proliferation; response to inactivity; cerebral cortex GABAergic interneuron migration; negative regulation of synaptic transmission, glutamatergic; regulation of sodium ion transport; arachidonic acid secretion; regulation of synaptic transmission, GABAergic; positive regulation of growth hormone secretion; G-protein coupled receptor internalization; reduction of cytosolic calcium ion concentration; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; peristalsis; branching morphogenesis of a nerve; negative regulation of circadian sleep/wake cycle, sleep; response to morphine; locomotory behavior; behavioral response to ethanol; orbitofrontal cortex development; negative regulation of cell proliferation; synaptogenesis; behavioral response to cocaine; adenohypophysis development; visual learning; nerve-nerve synaptic transmission; feeding behavior; circadian regulation of gene expression; response to axon injury; negative regulation of dopamine secretion; negative regulation of cell migration; response to iron ion; associative learning; grooming behavior; positive regulation of cytokinesis; negative regulation of protein secretion; negative regulation of protein kinase B signaling cascade; Wnt receptor signaling pathway; striatum development; regulation of cAMP metabolic process; regulation of potassium ion transport; regulation of heart rate; sensory perception of smell; negative regulation of adenylate cyclase activity; response to amphetamine; auditory behavior; regulation of dopamine uptake; response to cocaine; cellular calcium ion homeostasis; regulation of systemic arterial blood pressure by neurological process; negative regulation of dopamine receptor signaling pathway; pigmentation; long-term memory; axonogenesis; positive regulation of G-protein coupled receptor protein signaling pathway; release of sequestered calcium ion into cytosol; response to hypoxia; regulation of synapse structural plasticity; dopamine receptor, phospholipase C activating pathway
Reference #:  P14416 (UniProtKB)
Alt. Names/Synonyms: D(2) dopamine receptor; D2DR; D2R; Dopamine D2 receptor; dopamine receptor D2; dopamine receptor D2 isoform; DRD2
Gene Symbols: DRD2
Molecular weight: 50,619 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Select Structure to View Below

DRD2

Protein Structure Not Found.


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Sites Implicated In
signaling pathway regulation: S321‑p
activity, inhibited: S354‑p
intracellular localization: S354‑p
molecular association, regulation: S354‑p
receptor desensitization, inhibited: S321‑p
receptor internalization, altered: T225‑p
receptor internalization, induced: S321‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
2 0 T134-p AISIDRYtAVAMPML
1 0 T144-p AMPMLYNtRYssKRR
1 0 S147-p MLYNtRYssKRRVTV
1 0 S148-p LYNtRYssKRRVTVM
2 0 T225-p RRRKRVNtKRssRAF
2 0 S228-p KRVNtKRssRAFRAH
2 0 S229-p RVNtKRssRAFRAHL
1 0 K241 AHLRAPLKGNCTHPE
1 0 S321-p GLHSTPDsPAkPEKN
0 1 K324-m1 STPDsPAkPEKNGHA
0 1 K332-m1 PEKNGHAkDHPkIAK
0 1 K336-m1 GHAkDHPkIAKIFEI
2 0 S354-p PNGKTRTsLKTMsRR
0 1 S359-p RTsLKTMsRRKLSQQ
  DRD2 iso2  
T134-p AISIDRYtAVAMPML
T144 AMPMLYNTRYSSKRR
S147 MLYNTRYSSKRRVTV
S148 LYNTRYSSKRRVTVM
T225-p RRRKRVNtKRssRAF
S228-p KRVNtKRssRAFRAH
S229-p RVNtKRssRAFRAHL
K241 AHLRAPLKEAARRAQ
S292 GLHSTPDSPAKPEKN
K295 STPDSPAKPEKNGHA
K303 PEKNGHAKDHPKIAK
K307 GHAKDHPKIAKIFEI
S325-p PNGKTRTsLKTMSRR
S330 RTsLKTMSRRKLSQQ
  mouse

 
T134 AISIDRYTAVAMPML
T144 AMPMLYNTRYSSKRR
S147 MLYNTRYSSKRRVTV
S148 LYNTRYSSKRRVTVM
T225 KRRKRVNTKRSSRAF
S228 KRVNTKRSSRAFRAN
S229 RVNTKRSSRAFRANL
K241 ANLKTPLKGNCTHPE
S321 GLHSNPDSPAKPEKN
K324 SNPDSPAKPEKNGHA
K332 PEKNGHAKIVNPRIA
R337 HAKIVNPRIAKFFEI
S355 PNGKTRTSLKTMSRR
S360 RTSLKTMSRRKLSQQ
  rat

 
T134 AISIDRYTAVAMPML
T144 AMPMLYNTRYSSKRR
S147 MLYNTRYSSKRRVTV
S148 LYNTRYSSKRRVTVM
T225 KRRKRVNTKRSSRAF
S228 KRVNTKRSSRAFRAN
S229 RVNTKRSSRAFRANL
K241-ub ANLKTPLkGNCTHPE
S321 GLHSNPDSPAKPEKN
K324 SNPDSPAKPEKNGHA
K332 PEKNGHAKIVNPRIA
R337 HAKIVNPRIAKFFEI
S355 PNGKTRTSLKTMSRR
S360 RTSLKTMSRRKLSQQ
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