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Protein Page:
USP28 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
USP28 a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.2.15; EC 3.4.19.12; Ubiquitin-specific protease; Protease
Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus
Molecular Function: ubiquitin thiolesterase activity; protein binding; ubiquitin-specific protease activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein deubiquitination; DNA damage checkpoint; response to ionizing radiation; DNA repair; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to DNA damage stimulus
Reference #:  Q96RU2 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 28; KIAA1515; Ubiquitin carboxyl-terminal hydrolase 28; ubiquitin specific peptidase 28; ubiquitin specific protease 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28; UBP28; USP28
Gene Symbols: USP28
Molecular weight: 122,491 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

USP28

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S67‑p, S714‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T32 LNQLREITGIQDPSF
0 1 S38 ITGIQDPSFLHEALk
0 8 K45-ub SFLHEALkASNGDIT
0 19 K64-ub LLTDERVkEPsQDtV
1 4 S67-p DERVkEPsQDtVATE
0 1 T70-p VkEPsQDtVATEPSE
0 1 N84 EVEGSAANKEVLAKV
0 1 T130-p LNRMHEAtsAEtKRS
0 1 S131-p NRMHEAtsAEtKRSK
0 1 T134-p HEAtsAEtKRSKRKR
0 11 K243-ub SAALDLLkGAFRSSE
0 3 S375-p SRFEFNQsLGQPEKI
0 1 K425 EIKILQQKLERYVKY
0 1 Y447-p PLPDMLKyVIEFAST
0 1 K455 VIEFASTKPASESCP
0 2 S493-p KESTSTEsSsQDVES
1 1 S495-p STSTEsSsQDVESTF
0 1 S503-p QDVESTFssPEDSLP
0 1 S504-p DVESTFssPEDSLPK
0 1 K542 DEEINFVKtCLQRWR
0 1 T543-p EEINFVKtCLQRWRs
0 3 S550-p tCLQRWRsEIEQDIQ
0 1 Y654-p YINDKLPyFNAEAAP
2 3 S714-p ESSTNSSsQDYSTsQ
1 1 S720-p SsQDYSTsQEPSVAS
0 1 T753-p TAQAIANtARAYEKS
0 1 K839-ub FFQNEAPkRVVERTL
0 1 S863 SYDERSISIMKVAQA
0 1 K866 ERSISIMKVAQAKLK
0 1 K897-ub EDYSLFRkVSVyLLT
0 1 Y901-p LFRkVSVyLLTGLEL
0 2 T1048-p IVLKEPPtIRPNsPY
0 6 S1053-p PPtIRPNsPYDLCsR
0 1 S1059-p NsPYDLCsRFAAVME
  mouse

 
T32-p LNQLREItGIQDPsF
S38-p ItGIQDPsFLHEALk
K45-ub sFLHEALkASNGDIT
K64-ub LLTDQRVkEPSHDTT
S67 DQRVkEPSHDTTAAE
T70 VkEPSHDTTAAEPSE
S84-p EVEESATsKDLLAKV
N130 LNRAHEANSAETKRS
S131 NRAHEANSAETKRSK
T134 HEANSAETKRSKRKR
K243-ub SAALDLLkGAFRSSE
S376 SRFEFNQSLGQPEKI
K426-ub EIQVLQQkLERYVKY
Y448 PLPDMLKYVIEFAST
K456-ac VIEFASTkPASESCL
S494 KESSSPESCSQNAGS
S496 SSSPESCSQNAGSTF
S504 QNAGSTFSSPEDALP
S505 NAGSTFSSPEDALPS
K547-ub DEEMNFVkTCLQRWR
T548 EEMNFVkTCLQRWRs
S555-p TCLQRWRsEIEQDIQ
H659 YINDNLPHFSAEASS
S720 ESSPNSSSQDFSTSQ
S726 SSQDFSTSQESPAVS
T759 TAQAIANTAHAYEKS
K813 FFQNEAPKRVVERTL
S837-p SYDERSIsIMkVAQA
K840-ac ERSIsIMkVAQAKLM
K871 EDYSLFRKVSVYLLT
Y875 LFRKVSVYLLTGLEL
T1022-p IVLKEPPtIRPNsPY
S1027-p PPtIRPNsPYDLCNR
N1033 NsPYDLCNRFAAVME
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