a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Protease; Ubiquitin-specific protease; EC 184.108.40.206
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus
Molecular Function: ubiquitin thiolesterase activity; protein binding; ubiquitin-specific protease activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein deubiquitination; DNA damage checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.