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USP28 (human)

Overview USP28 a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Protease; EC 3.1.2.15 Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus Molecular Function: ubiquitin thiolesterase activity; protein binding; ubiquitin-specific protease activity Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein deubiquitination; DNA damage checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis Reference #:  Q96RU2 (UniProtKB) Alt. Names/Synonyms: Deubiquitinating enzyme 28; KIAA1515; Ubiquitin carboxyl-terminal hydrolase 28; ubiquitin specific peptidase 28; ubiquitin specific protease 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28; UBP28; USP28 Gene Symbols: USP28 Molecular weight: 122,491 Da Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below USP28 2LVA - A=22-132 (human)

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	Sites Implicated In
apoptosis, altered: S67‑p, S714‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T32	LNQLREITGIQDPSF
0	1		S38	ITGIQDPSFLHEALk
0	8		K45-u	SFLHEALkASNGDIT
0	19		K64-u	LLTDERVkEPsQDtV
1	2		S67-p	DERVkEPsQDtVATE
0	1		T70-p	VkEPsQDtVATEPSE
0	1		N84	EVEGSAANKEVLAKV
0	1		T130-p	LNRMHEAtsAEtKRS
0	1		S131-p	NRMHEAtsAEtKRSK
0	1		T134-p	HEAtsAEtKRSKRKR
0	11		K243-u	SAALDLLkGAFRSSE
0	1		K425	EIKILQQKLERYVKY
0	1		Y447-p	PLPDMLKyVIEFAST
0	1		K455	VIEFASTKPASESCP
0	2		S493-p	KESTSTEsSsQDVES
1	1		S495-p	STSTEsSsQDVESTF
0	1		K542	DEEINFVKtCLQRWR
0	1		T543-p	EEINFVKtCLQRWRs
0	3		S550-p	tCLQRWRsEIEQDIQ
0	1		Y654-p	YINDKLPyFNAEAAP
2	3		S714-p	ESSTNSSsQDYSTsQ
1	1		S720-p	SsQDYSTsQEPSVAS
0	1		K839-u	FFQNEAPkRVVERTL
0	1		K866	ERSISIMKVAQAKLK
0	1		K897-u	EDYSLFRkVSVyLLT
0	1		Y901-p	LFRkVSVyLLTGLEL
0	1		T1048	IVLKEPPTIRPNsPY
0	4		S1053-p	PPTIRPNsPYDLCsR
0	1		S1059-p	NsPYDLCsRFAAVME

	mouse
T32-p	LNQLREItGIQDPsF
S38-p	ItGIQDPsFLHEALk
K45-u	sFLHEALkASNGDIT
K64-u	LLTDQRVkEPSHDTT
S67	DQRVkEPSHDTTAAE
T70	VkEPSHDTTAAEPSE
S84-p	EVEESATsKDLLAKV
N130	LNRAHEANSAETKRS
S131	NRAHEANSAETKRSK
T134	HEANSAETKRSKRKR
K243-u	SAALDLLkGAFRSSE
K426-u	EIQVLQQkLERYVKY
Y448	PLPDMLKYVIEFAST
K456-a	VIEFASTkPASESCL
S494	KESSSPESCSQNAGS
S496	SSSPESCSQNAGSTF
K547-u	DEEMNFVkTCLQRWR
T548	EEMNFVkTCLQRWRs
S555-p	TCLQRWRsEIEQDIQ
H659	YINDNLPHFSAEASS
S720	ESSPNSSSQDFSTSQ
S726	SSQDFSTSQESPAVS
K813	FFQNEAPKRVVERTL
K840-a	ERSISIMkVAQAKLM
K871	EDYSLFRKVSVYLLT
Y875	LFRKVSVYLLTGLEL
T1022-p	IVLKEPPtIRPNsPY
S1027-p	PPtIRPNsPYDLCNR
N1033	NsPYDLCNRFAAVME

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