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Protein Page:
USP28 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
USP28 a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Ubiquitin-specific protease; EC 3.1.2.15; Protease
Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus
Molecular Function: ubiquitin thiolesterase activity; protein binding; ubiquitin-specific protease activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein deubiquitination; DNA damage checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
Reference #:  Q96RU2 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 28; KIAA1515; Ubiquitin carboxyl-terminal hydrolase 28; ubiquitin specific peptidase 28; ubiquitin specific protease 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28; UBP28; USP28
Gene Symbols: USP28
Molecular weight: 122,491 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

USP28

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S67‑p, S714‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 K45-u SFLHEALkASNGDIT
0 19 K64-u LLTDERVkEPsQDTV
1 3 S67-p DERVkEPsQDTVATE
0 11 K243-u SAALDLLkGAFRSSE
0 1 S375-p SRFEFNQsLGQPEKI
0 1 K425 EIKILQQKLERYVKY
0 2 S493-p KESTSTEsSsQDVES
1 1 S495-p STSTEsSsQDVESTF
0 1 K542 DEEINFVKTCLQRWR
0 3 S550-p TCLQRWRsEIEQDIQ
2 3 S714-p ESSTNSSsQDYSTsQ
1 1 S720-p SsQDYSTsQEPSVAS
0 1 K839-u FFQNEAPkRVVERTL
0 5 S1053-p PPTIRPNsPYDLCSR
  mouse

 
K45-u SFLHEALkASNGDIT
K64-u LLTDQRVkEPSHDTT
S67 DQRVkEPSHDTTAAE
K243-u SAALDLLkGAFRSSE
S376 SRFEFNQSLGQPEKI
K426-u EIQVLQQkLERYVKY
S494 KESSSPESCSQNAGS
S496 SSSPESCSQNAGSTF
K547-u DEEMNFVkTCLQRWR
S555-p TCLQRWRsEIEQDIQ
S720 ESSPNSSSQDFSTSQ
S726 SSQDFSTSQESPAVS
K813 FFQNEAPKRVVERTL
S1027-p PPTIRPNsPYDLCNR
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