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Protein Page:
SIRT3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SIRT3 a soluble mitochondrial NAD-dependent protein deacetylase. Can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase. Mitochondrial proteins are hyperacetylated in SIRT3-deficient mice, but not in SIRT4 or SIRT5 deficient mice. SIRT3-deficient mice have no obvious metabolic phenotype, and the process of adaptive thermogenesis is normal. Can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that participates in regulation of the citric acid cycle and the regeneration of antioxidants. Inhibited by nicotinamide, but not by trichostatin A. Its unprocessed form is enzymatically inactive. It is processed by mitochondrial processing peptidase (MPP) in the mitochondrial matrix to give an enzymatically active 28 kDa product. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.1.-; Mitochondrial; Deacetylase
Cellular Component: mitochondrion; membrane; mitochondrial matrix
Molecular Function: protein binding; zinc ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD+ ADP-ribosyltransferase activity
Biological Process: protein amino acid ADP-ribosylation; protein amino acid deacetylation; aerobic respiration
Reference #:  Q9NTG7 (UniProtKB)
Alt. Names/Synonyms: hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; NAD-dependent deacetylase sirtuin-3, mitochondrial; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIR2L3; SIRT3; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin type 3
Gene Symbols: SIRT3
Molecular weight: 43,573 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SIRT3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R51-m1 DDVSAGLrGSHGArG
0 1 R57-m1 LrGSHGArGEPLDPA
0 1 S105-p GRRSISFsVGASsVV
0 1 S110-p SFsVGASsVVGSGGS
0 1 T284-p VPRCPVCtGVVKPDI
0 1 T391-p RDLVQREtGKLDGPD
  mouse

 
- gap
- gap
C41 GRRPISLCVGASGGF
G46 SLCVGASGGFGGGGS
T219 VPRCPVCTGVVKPDI
R326 LDLMQRERGKLDGQD
  rat

 
- gap
- gap
- under review  
- gap
T142 VPRCPVCTGVVKPDI
N249 QDLIQRENGKLDGQD
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