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Protein Page:
ORC6L (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ORC6L Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Cellular Component: nucleoplasm; nuclear origin of replication recognition complex; origin recognition complex
Molecular Function: protein binding; DNA binding
Biological Process: mitotic cell cycle; DNA replication; DNA-dependent DNA replication; G1/S transition of mitotic cell cycle
Reference #:  Q9Y5N6 (UniProtKB)
Alt. Names/Synonyms: ORC6; ORC6L; Origin recognition complex subunit 6; origin recognition complex, subunit 6 homolog-like; origin recognition complex, subunit 6 like (yeast)
Gene Symbols: ORC6
Molecular weight: 28,107 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ORC6L

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 D19 RLGLAEPDMLRKAEE
0 2 Y67-p KCPLDRAyLIKLSGL
1 51 T195-p REPGDVAtPPRKRKK
0 2 - gap
0 1 - gap
0 1 T229-p PQKDEDLtQDyEEWK
0 5 Y232-p DEDLtQDyEEWKRKI
0 1 K248-u ENAASAQkATAE___
  mouse

 
S19-p RLGLAEPsVLRKAEE
Y67 KCPLDRAYLIRLSGL
R195 RDSADLARPALKRKK
S206-p KRKKPEFsPtLKKKE
T208-p KKPEFsPtLKKKEPG
T239 LPKDEDLTQDYEEWK
Y242 DEDLTQDYEEWKRKI
T258 ENAAKAQTATAE___
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