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ORC6L (human)

Overview ORC6L Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family. Note: This description may include information from UniProtKB. Protein type: DNA replication Cellular Component: nucleoplasm; nuclear origin of replication recognition complex; origin recognition complex Molecular Function: protein binding; DNA binding Biological Process: M/G1 transition of mitotic cell cycle; mitotic cell cycle; DNA replication; S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle Reference #:  Q9Y5N6 (UniProtKB) Alt. Names/Synonyms: ORC6; ORC6L; Origin recognition complex subunit 6; origin recognition complex, subunit 6 homolog-like; origin recognition complex, subunit 6 like (yeast) Gene Symbols: ORC6 Molecular weight: 28,107 Da Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ORC6L 3M03 - A/C/B=94-187 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		D19	RLGLAEPDMLRKAEE
0	2		Y67-p	KCPLDRAyLIKLSGL
0	1		T78-p	LSGLNKEtyQsCLKS
0	1		Y79-p	SGLNKEtyQsCLKSF
0	1		S81-p	LNKEtyQsCLKSFEC
0	1		K160	KLKVDKNKMVATSGV
0	1		K168-a	MVATSGVkKAIFDRL
0	1		K168-u	MVATSGVkKAIFDRL
0	1		K169	VATSGVkKAIFDRLC
1	48		T195-p	REPGDVAtPPRKRKK
0	2		-	gap
0	1		-	gap
0	1		K214-a	APAKEMEkVEEMPHk
0	1		K221-a	kVEEMPHkPQKDEDL
0	1		T229-p	PQKDEDLtQDyEEWK
0	5		Y232-p	DEDLtQDyEEWKRKI
0	1		K248-u	ENAASAQkATAE___

	mouse
S19-p	RLGLAEPsVLRKAEE
Y67	KCPLDRAYLIRLSGL
M78	LSGLNKMMYQSCLKS
Y79	SGLNKMMYQSCLKSF
S81	LNKMMYQSCLKSFEC
K160-a	KIKVDKTkMITTSGV
K168	MITTSGVKkAILDRL
K168	MITTSGVKkAILDRL
K169-a	ITTSGVKkAILDRLC
R195	RDSADLARPALKRKK
S206-p	KRKKPEFsPtLKKKE
T208-p	KKPEFsPtLKKKEPG
V225	PPAKEIEVIETLHKL
K231	EVIETLHKLPKDEDL
T239	LPKDEDLTQDYEEWK
Y242	DEDLTQDYEEWKRKI
T258	ENAAKAQTATAE___

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