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Protein Page:
ANKRD15 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ANKRD15 Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Defects in KANK1 are the cause of cerebral palsy spastic quadriplegic type 2 (CPSQ2). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly. 2 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 9p24.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; beta-catenin binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of Rho protein signal transduction; negative regulation of actin filament polymerization; negative regulation of insulin receptor signaling pathway; negative regulation of cell migration; positive regulation of Wnt receptor signaling pathway
Reference #:  Q14678 (UniProtKB)
Alt. Names/Synonyms: ANKRD15; ankyrin repeat domain 15; Ankyrin repeat domain-containing protein 15; DKFZp451G231; KANK; KANK1; KIAA0172; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1; KN motif and ankyrin repeat domains 1; MGC43128
Gene Symbols: KANK1
Molecular weight: 147,289 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
Select Structure to View Below

ANKRD15

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S20-p GKAGDILsGDQDKEQ
0 5 S70-p IQKRRKPsVPCPEPR
0 1 R110 CPNFLIARSQVTStP
0 1 T116-p ARSQVTStPISKPPP
0 1 K120 VTStPISKPPPPLET
0 2 S128-p PPPPLETsLPFLtIP
0 1 T133-p ETsLPFLtIPENRQL
0 1 T175-p ERATMQMtPGEFRRP
0 20 S186-p FRRPRLAsFGGMGTT
0 1 S194-p FGGMGTTsSLPSFVG
0 2 S242-p MGSSIRHsPLSSGIS
0 1 S246 IRHsPLSSGISTPVT
0 1 T253 SGISTPVTNVsPMHL
0 1 S256-p STPVTNVsPMHLQHI
0 1 T283-p ELEEQVRtIPVLQVK
0 1 S312-p LKNQRAAsQINVCGV
0 8 S323-p VCGVRKRsysAGNAs
0 3 Y324-p CGVRKRsysAGNAsQ
0 23 S325-p GVRKRsysAGNAsQL
0 4 S330-p sysAGNAsQLEQLSR
0 2 S341-p QLSRARRsGGELYID
0 1 A405 CRSVAVGAEENMNDI
0 1 T429-p CKDAAVGtLVEMRNC
0 1 T479-p LEVQLREttHDREMT
0 1 T480-p EVQLREttHDREMTK
0 2 T505-p RKKVDKAtMAQPLVF
0 1 S513-p MAQPLVFsKVVEAVV
0 1 T522-p VVEAVVQtRDQMVGs
0 1 S529-p tRDQMVGsHMDLVDT
0 1 T544-p CVGTSVEtNsVGISC
0 1 S546-p GTSVEtNsVGISCQP
0 1 S585-p HDRCAGRsVEMCDKs
0 1 S592-p sVEMCDKsVSVEVSV
0 1 T756-p DRPSAVKtKESGVGQ
0 1 Y770-p QININDNyLVGLKMR
0 1 S879-p SINSVMKsAstEELR
0 5 S881-p NSVMKsAstEELRNP
0 1 T882-p SVMKsAstEELRNPD
0 1 K892-ub LRNPDFQkTSLGKIT
0 1 K935 EVGTSEGKPISSLDA
0 1 S1331 VNFAKAQSPGTPRLG
0 1 G1333 FAKAQSPGTPRLGRK
0 2 T1341-p TPRLGRKtsPGPtHR
0 2 S1342-p PRLGRKtsPGPtHRG
0 1 T1346-p RKtsPGPtHRGsFD_
0 6 S1350-p PGPtHRGsFD_____
  mouse

 
N20 EKADGVLNGDHNKEK
S70-p IQKRRKPsVPCPEVR
R110 CPSFLLARSHVTSTP
T116 ARSHVTSTPIPrPPA
R120-m1 VTSTPIPrPPAPLET
S128-p PPAPLETsPTFAVSE
S134 TsPTFAVSENRQLLP
A175 ERVTMQMAPGDFRRP
S186 FRRPRLASFGGMGST
S194 FGGMGSTSSLPSFVG
S242-p MGSSVRHsPLSsGIS
S246-p VRHsPLSsGISTPVt
T253-p sGISTPVtNVSPMHL
S256 STPVtNVSPMHLQHI
T283 ELEEQVRTIPVLQVK
S312 LKSQRASSQNEACGV
S323-p ACGVRKRsysAGNAs
Y324-p CGVRKRsysAGNAsQ
S325-p GVRKRsysAGNAsQL
S330-p sysAGNAsQLELLAR
G341 LLARARRGGGELYID
S410-p CKSVAVGsDENMNDV
T434 CKDTAVGTVTETRNV
T484 LEVQLKETTHDREMT
T485 EVQLKETTHDREMTK
T510 RKKVDKATMAQPLVF
S518 MAQPLVFSKLVEALV
T527 LVEALVPTRDQMVGS
S534 TRDQMVGSHVDTRES
T549 CVGTSVQTSSVGTSC
S551 GTSVQTSSVGTSCHP
S590 HDQCVGRSVETCDRS
S597 SVETCDRSVGVEVSV
T761 DRPCAVKTKESGVGQ
Y775 QINIQDNYLVGLKMR
S885 SINSVMKSAsTEELR
S887-p NSVMKSAsTEELRNS
T888 SVMKSAsTEELRNSD
K898 LRNSDFQKASLGKTT
K941-ub EAETAEGkHSRGHEQ
S1339-p LNFSKAQsPsTPRLG
S1341-p FSKAQsPsTPRLGRK
T1349 TPRLGRKTsPGPTHR
S1350-p PRLGRKTsPGPTHRG
T1354 RKTsPGPTHRGsFD_
S1358-p PGPTHRGsFD_____
  rat

 
N20 ENADGVLNGDRNKEK
S70 IQKRRKPSGPCAEVR
R110-m1 CPSFLLArSHVTSTP
T116 ArSHVTSTPIPRPPA
R120 VTSTPIPRPPAPLET
S128 PPAPLETSPTFAISE
S134 TSPTFAISENRQLLP
A175 ERVTMQMAPGEFRRP
S186 FRRPRLASFGGMGST
S194 FGGMGSTSSLPSFMG
S242 MGSSVRHSPLSSGIS
S246 VRHSPLSSGISTPVT
T253 SGISTPVTNVSPMHL
S256 STPVTNVSPMHLQHI
T283 ELEEQVRTIPVLQVK
S312 LKNQRAASQNEACGV
S323-p ACGVRKRsYsAGNAS
Y324 CGVRKRsYsAGNASQ
S325-p GVRKRsYsAGNASQL
S330 sYsAGNASQLELLSR
G341 LLSRARRGGGELYID
S410 RKSVAVGSDENMNDI
T434 RKDTAVGTVTETRNF
T484 LEVQLKETTHDQEMT
T485 EVQLKETTHDQEMTK
I510 RKKVDKAIMAQPLVF
S518 MAQPLVFSKLVEALV
T527 LVEALVPTREQMVGS
S534 TREQMVGSHVDTMDS
T549 CVGTSVQTSSVGTSC
S551 GTSVQTSSVGTSCHP
S590 HDRCVGRSVETCNRS
S597 SVETCNRSVGVEVSV
T761 DKPCAVKTKESGVGQ
Y775 QINIHDNYLVGLKMR
S885 SINSVMKSAsTEELR
S887-p NSVMKSAsTEELRNP
T888 SVMKSAsTEELRNPD
K898 LRNPDFQKSSLGKIA
K941 ETETTEGKRGCEQFL
S1339 LNFSKAQSPSTPRLG
S1341 FSKAQSPSTPRLGRK
T1349-p TPRLGRKtSPGPTHR
S1350 PRLGRKtSPGPTHRG
T1354 RKtSPGPTHRGsFD_
S1358-p PGPTHRGsFD_____
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