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FZD6 (human)

Overview FZD6 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB. Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Receptor, GPCR Cellular Component: apical part of cell; integral to plasma membrane; apicolateral plasma membrane; cytoplasm; plasma membrane Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; protein binding; ubiquitin protein ligase binding; PDZ domain binding Biological Process: platelet activation; inner ear morphogenesis; gonad development; axonogenesis; hair follicle development; Wnt receptor signaling pathway, planar cell polarity pathway; negative regulation of transcription factor activity; neural tube closure; G-protein signaling, coupled to cGMP nucleotide second messenger; establishment of planar polarity; angiogenesis; cell proliferation in midbrain Reference #:  O60353 (UniProtKB) Alt. Names/Synonyms: frizzled homolog 6 (Drosophila); Frizzled-6; Fz-6; FZ6; FZD6; hFz6; seven transmembrane helix receptor Gene Symbols: FZD6 Molecular weight: 79,292 Da Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FZD6

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K191-u	PCPNMYFkSDELEFA
0	2		S606-p	EVKADGAstPRLREQ
0	2		T607-p	VKADGAstPRLREQD
0	9		S620-p	QDCGEPAsPAAsIsR
0	2		S624-p	EPAsPAAsIsRLsGE
0	1		S626-p	AsPAAsIsRLsGEQV
0	2		S629-p	AAsIsRLsGEQVDGk
0	1		K636-u	sGEQVDGkGQAGSVS
0	2		S653-p	ARSEGRIsPKSDITD
0	1		S673	SNNLQVPSSSEPSSL
0	1		S674	NNLQVPSSSEPSSLK

	mouse
K191	PCPNMYFKSDELDFA
N606	EGRADRANTPSAKDR
T607	GRADRANTPSAKDRD
G620	RDCGESAGPSSKLSG
K624	ESAGPSSKLSGNRNG
S626	AGPSSKLSGNRNGRE
G631	KLSGNRNGRESRAGG
K640	ESRAGGLKERSNGSE
S656-p	APSEGRVsPKSSVPE
S676-p	CSTSQAAssPEPTSL
S677-p	STSQAAssPEPTSLK

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