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Protein Page:
FZD6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FZD6 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, Fz/Smo family; Receptor, GPCR
Cellular Component: apicolateral plasma membrane; integral to plasma membrane; apical part of cell; cytoplasm; plasma membrane
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; protein binding; ubiquitin protein ligase binding; PDZ domain binding
Biological Process: platelet activation; inner ear morphogenesis; gonad development; axonogenesis; hair follicle development; Wnt receptor signaling pathway, planar cell polarity pathway; negative regulation of transcription factor activity; neural tube closure; establishment of planar polarity; G-protein signaling, coupled to cGMP nucleotide second messenger; angiogenesis; cell proliferation in midbrain
Reference #:  O60353 (UniProtKB)
Alt. Names/Synonyms: frizzled homolog 6 (Drosophila); Frizzled-6; Fz-6; FZ6; FZD6; hFz6
Gene Symbols: FZD6
Molecular weight: 79,292 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FZD6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T5-p ___MEMFtFLLTCIF
0 1 T150-ga FLGPQKKtEQVQRDI
0 1 K191-ub PCPNMYFkSDELEFA
0 1 S496-p SAVFWVGsKKTCTEW
0 1 S526-p SRRVLQEsCEFFLKH
0 4 S606-p EVKADGAstPRLREQ
0 4 T607-p VKADGAstPRLREQD
0 11 S620-p QDCGEPAsPAAsIsR
0 4 S624-p EPAsPAAsIsRLsGE
0 1 S626-p AsPAAsIsRLsGEQV
0 3 S629-p AAsIsRLsGEQVDGk
0 1 K636-ub sGEQVDGkGQAGsVS
0 1 S641-p DGkGQAGsVSESARS
0 3 S653-p ARSEGRIsPKSDITD
0 1 S673 SNNLQVPSSSEPSSL
0 1 S674 NNLQVPSSSEPSSLK
  mouse

 
S4 ____MERSPFLLACI
S150 LSGPQKKSDQVPRDI
K191 PCPNMYFKSDELDFA
S496 SAVFWVGSKKTCTEW
S526 SRRVLQESCEFFLKH
N606 EGRADRANTPSAKDR
T607 GRADRANTPSAKDRD
- gap
- gap
- gap
- gap
- gap
N644 GGLKERSNGSEGAPS
S656-p APSEGRVsPKSSVPE
S676-p CSTSQAAssPEPTSL
S677-p STSQAAssPEPTSLK
  rat

 
S4 ____MEASPFLSACI
T150 LFGPQKKTDQVPRDI
K191 PCPNMYFKSDELDFA
S496 SAVFWVGSKKTCTEW
S526 SRRVLQESCEFFLKH
N606 EGRADRANTPRAKGP
T607 GRADRANTPRAKGPD
S620 PDCGEPASTAASNSK
S624 EPASTAASNSKFSGD
S626 ASTAASNSKFSGDQI
S629 AASNSKFSGDQIDRK
K636 SGDQIDRKSRAGSVK
- under review  
S659-p APSEGRVsPKGVPGT
S677 ECTLQIPSSPEPNSL
S678 CTLQIPSSPEPNSLK
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