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Protein Page:
NR2F1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NR2F1 Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2. Inhibited by gonadotropin in granulosa cells. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Nuclear receptor; DNA binding protein
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; neuron migration; positive regulation of transcription from RNA polymerase II promoter; gene expression; cerebral cortex regionalization; negative regulation of transcription from RNA polymerase II promoter; signal transduction
Reference #:  P10589 (UniProtKB)
Alt. Names/Synonyms: COT1; COUP transcription factor 1; COUP transcription factor I; COUP-TF I; COUP-TF1; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F1; NR2F2; Nuclear receptor subfamily 2 group F member 1; nuclear receptor subfamily 2, group F, member 1; SVP44; TCFCOUP1; TFCOUP1; transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3); V-erbA-related protein 3
Gene Symbols: NR2F1
Molecular weight: 46,156 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NR2F1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 9 T51-p AGSGAPHtPQtPGQP
0 7 T54-p GAPHtPQtPGQPGAP
0 9 T63-p GQPGAPAtPGTAGDK
0 2 Y355-p SQCALEEyVRSQYPN
0 3 K396-u FFVRLVGkTPIETLI
  mouse

► Hide Isoforms
 
T50 AGSGAPHTPQTPGQP
T53 GAPHTPQTPGQPGAP
T62 GQPGAPATPGTQGDK
Y354-p SQCALEEyVRSQYPN
K395-u FFVRLVGkTPIETLI
  NR2F1 iso2  
T48-p AGSGAPHtPQtPGQP
T51-p GAPHtPQtPGQPGAP
T60-p GQPGAPAtPGTAGDK
Y352 SQCALEEYVRSQYPN
K393 FFVRLVGKTPIETLI
  rat

 
T48 AGSGAPHTPQTPGQP
T51 GAPHTPQTPGQPGAP
T60 GQPGAPATPGTAGDK
Y351 SQCALEEYVRSQYPN
K392 FFVRLVGKTPIETLI
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