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Protein Page:
TXNDC3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TXNDC3 Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Defects in NME8 are the cause of primary ciliary dyskinesia type 6 (CILD6). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Kinase, nucleoside diphosphate; Other group; NDK family
Cellular Component: cytoplasm
Molecular Function: nucleoside diphosphate kinase activity; ATP binding
Biological Process: GTP biosynthetic process; CTP biosynthetic process; cell redox homeostasis; multicellular organismal development; UTP biosynthetic process; spermatogenesis; cell differentiation
Reference #:  Q8N427 (UniProtKB)
Alt. Names/Synonyms: CILD6; NM23-H8; NME8; sperm-specific thioredoxin 2; Spermatid-specific thioredoxin-2; Sptrx-2; SPTRX2; thioredoxin domain containing 3 (spermatozoa); Thioredoxin domain-containing protein 3; TXND3; TXNDC3
Gene Symbols: NME8
Molecular weight: 67,270 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Select Structure to View Below

TXNDC3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K81 TLQPFRDKCEPVFLF
  TXNDC3 iso3  
K26-m2 TLQPFRDkCEPVFLF
  TXNDC3 iso5  
K81 TLQPFRDKCEPVFLF
  mouse

 
K81 TLQPFRDKCEPVFLF
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