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Protein Page:
TXNDC3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

TXNDC3 Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Defects in NME8 are the cause of primary ciliary dyskinesia type 6 (CILD6). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Kinase, nucleoside diphosphate; Other group; NDK family
Cellular Component: cytoplasm
Molecular Function: nucleoside diphosphate kinase activity; ATP binding
Biological Process: GTP biosynthetic process; CTP biosynthetic process; cell redox homeostasis; UTP biosynthetic process; multicellular organismal development; spermatogenesis; cell differentiation
Reference #:  Q8N427 (UniProtKB)
Alt. Names/Synonyms: CILD6; NM23-H8; NME8; sperm-specific thioredoxin 2; Spermatid-specific thioredoxin-2; Sptrx-2; SPTRX2; thioredoxin domain containing 3 (spermatozoa); Thioredoxin domain-containing protein 3; TXND3; TXNDC3
Gene Symbols: NME8
Molecular weight: 67,270 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


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  TXNDC3 iso3  
  TXNDC3 iso5  

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