PAX3 (human)

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Protein Page:

PAX3 (human)

p	Phosphorylation
a	Acetylation
m	Methylation
m1	Mono-methylation
m2	Di-methylation
m3	Tri-methylation
u	Ubiquitination
s	Sumoylation
n	Neddylation
g	O-GlcNAc
h	Palmitoylation
ad	Adenylylation
sn	S-Nitrosylation
ca	Caspase cleavage

Overview

PAX3 Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.

Protein type: DNA binding protein; Transcription factor

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; organ morphogenesis; sensory perception of sound; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Reference #: P23760 (UniProtKB)

Alt. Names/Synonyms: CDHS; HUP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; paired box 3; paired box homeotic gene 3; Paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; PAX3; WS1; WS3

Gene Symbols: PAX3

Molecular weight: 52,968 Da

Basal Isoelectric point: 8.92 Predict pI for various phosphorylation states

Protein-Specific Antibodies or siRNAs from Cell Signaling Technology^®

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	PAX3

Modification Sites and Domains

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Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment

SS SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.		human ► Hide Isoforms

0	1	T2-p	______MttLAGAVP
0	1	T3-p	_____MttLAGAVPR
0	1	K107-a	AIGGSKPkQVTTPDV
0	1	K116-a	VTTPDVEkKIEEyKR
0	1	Y121-p	VEkKIEEyKRENPGM
0	2	K182-a	KEAEESEkkAKHSID
0	2	K183-a	EAEESEkkAKHSIDG
2	0	S201	ERASAPQSDEGsDID
4	0	S205-p	APQSDEGsDIDSEPD
2	0	S209	DEGsDIDSEPDLPLK
1	0	K437-a	SQRLDHMkSLDSLPT
1	0	K475-a	YGQYGQSkPWTF___
0	1	-	gap
0	1	-	gap

	PAX3 iso3

T2	______MTTLAGAVP
T3	_____MTTLAGAVPR
K107	AIGGSKPKQVTTPDV
K116	VTTPDVEKKIEEyKR
Y121-p	VEKKIEEyKRENPGM
K182	KEAEESEKKAKHSID
K183	EAEESEKKAKHSIDG
S201	ERGKALVSGVSSH__
S205	ALVSGVSSH______
-	gap
-	gap
-	gap
-	gap
-	gap

	PAX3 iso5

T2	______MTTLAGAVP
T3	_____MTTLAGAVPR
K107	AIGGSKPKQVTTPDV
K116	VTTPDVEKKIEEYKR
Y121	VEKKIEEYKRENPGM
K182	KEAEESEKKAKHSID
K183	EAEESEKKAKHSIDG
S201	ERASAPQSDEGSDID
S205	APQSDEGSDIDSEPD
S209	DEGSDIDSEPDLPLK
K437	SQRLDHMKSLDSLPT
K480	QSAFHYLKPDIAWFQ
S496-p	LLNTFDKssGEEEDL
S497-p	LNTFDKssGEEEDLE

	mouse

T2	______MTTLAGAVP
T3	_____MTTLAGAVPR
K107	AIGGSKPKQVTTPDV
K116	VTTPDVEKKIEEYKR
Y121	VEKKIEEYKRENPGM
K182	KEAEESEKKAKHSID
K183	EAEESEKKAKHSIDG
S201-p	ERASAPQsDEGsDID
S205-p	APQsDEGsDIDsEPD
S209-p	DEGsDIDsEPDLPLK
K437	SQRLEHMKNVDSLPT
-	gap
-	gap
-	gap

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