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Protein Page:
PAX3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PAX3 Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; muscle development; apoptosis; positive regulation of transcription, DNA-dependent; heart development; pigmentation during development; neuron fate commitment; negative regulation of transcription from RNA polymerase II promoter; cell proliferation; organ morphogenesis; sensory perception of sound; positive regulation of cell proliferation; neural tube closure; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis; neural crest cell migration
Reference #:  P23760 (UniProtKB)
Alt. Names/Synonyms: CDHS; HUP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; paired box 3; paired box homeotic gene 3; Paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; PAX3; WS1; WS3
Gene Symbols: PAX3
Molecular weight: 52,968 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAX3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K182-a KEAEESEkkAKHSID
0 2 K183-a EAEESEkkAKHSIDG
2 0 S201 ERASAPQSDEGsDID
4 0 S205-p APQSDEGsDIDSEPD
2 0 S209 DEGsDIDSEPDLPLK
1 0 K437-a SQRLDHMkSLDSLPT
1 0 K475-a YGQYGQSkPWTF___
  PAX3 iso3  
K182 KEAEESEKKAKHSID
K183 EAEESEKKAKHSIDG
S201 ERGKALVSGVSSH__
S205 ALVSGVSSH______
- gap
- gap
- gap
  PAX3 iso8  
K182 KEAEESEKKAKHSID
K183 EAEESEKKAKHSIDG
S201 ERASAPQSDEGSDID
S205 APQSDEGSDIDSEPD
S209 DEGSDIDSEPDLPLK
K437 SQRLDHMKSLDSLPT
K480 QSAFHYLKPDIAWFQ
  mouse

 
K182 KEAEESEKKAKHSID
K183 EAEESEKKAKHSIDG
S201-p ERASAPQsDEGsDID
S205-p APQsDEGsDIDsEPD
S209-p DEGsDIDsEPDLPLK
K437 SQRLEHMKNVDSLPT
- gap
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