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Protein Page:
M-CSF (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
M-CSF Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cytokine
Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; plasma membrane; extracellular region; integral to membrane; receptor complex
Molecular Function: protein binding; protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding
Biological Process: positive regulation of monocyte differentiation; ossification; macrophage differentiation; immune system process; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; reproductive developmental process; positive regulation of odontogenesis of dentine-containing teeth; positive regulation of multicellular organism growth; osteoclast differentiation; odontogenesis; cell proliferation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; positive regulation of cell proliferation; innate immune response; positive regulation of Ras protein signal transduction; inflammatory response; positive regulation of macrophage differentiation; regulation of ossification; positive regulation of cell-matrix adhesion; positive regulation of cell migration
Reference #:  P07141 (UniProtKB)
Alt. Names/Synonyms: C87615; colony stimulating factor 1 (macrophage); CSF-1; Csf1; Csfm; Macrophage colony-stimulating factor 1; MCSF; op; osteopetrosis; Processed macrophage colony-stimulating factor 1
Gene Symbols: Csf1
Molecular weight: 60,649 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
Select Structure to View Below

M-CSF

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S30-p VCLLMSRsIAKEVSE
0 1 R181-m2 SFAKCSSrDVVTKPD
0 1 S256 AKQRPPRSTCQTLES
0 1 T257 KQRPPRSTCQTLEST
0 1 Q266 QTLESTEQPNHGDRL
0 1 S343 TDRPRALSASPFPKS
0 1 S345 RPRALSASPFPKSTE
0 1 S350 SASPFPKSTEDQKPV
0 1 T360 DQKPVDITDRPLTEV
0 1 R362 KPVDITDRPLTEVNP
0 1 I373 EVNPMRPIGQTQNNT
0 1 T380 IGQTQNNTPEKTDGT
0 1 T384 QNNTPEKTDGTSTLR
0 1 S388 PEKTDGTSTLREDHQ
0 1 V417 VSNSATPVAQLLLPK
0 1 P423 PVAQLLLPKSHSWGI
0 1 S425 AQLLLPKSHSWGIVL
0 1 S427 LLLPKSHSWGIVLPL
0 1 W428 LLPKSHSWGIVLPLG
0 1 I430 PKSHSWGIVLPLGEL
0 1 S448 RSTRDRRSPAELEGG
0 1 S458 ELEGGSASEGAARPV
0 1 S470 RPVARFNSIPLTDTG
0 1 T474 RFNSIPLTDTGHVEQ
0 1 S530 RDPQTLDSSVGRPED
  human

 
S30 VCLLASRSITEEVSE
Q181 SFAECSSQDVVTKPD
S256-ga AKQRPPRstCQSFEP
T257-ga KQRPPRstCQSFEPP
T266-ga QSFEPPEtPVVKDST
S345-p ARPSNFLsASsPLPA
S348-p SNFLsASsPLPAsAK
S353-p ASsPLPAsAKGQQPA
T363-ga GQQPADVtGtALPRV
T365-ga QPADVtGtALPRVGP
T376-ga RVGPVRPtGQDWNHt
T383-ga tGQDWNHtPQKtDHP
T387-ga WNHtPQKtDHPsALL
S391-ga PQKtDHPsALLRDPP
S420-p LSNPSTLsAQPQLsR
S426-p LsAQPQLsRsHssGs
S428-ga AQPQLsRsHssGsVL
S430-ga PQLsRsHssGsVLPL
S431-ga QLsRsHssGsVLPLG
S433-ga sRsHssGsVLPLGEL
S451-ga RSTRDRRsPAEPEGG
S461-ga EPEGGPAsEGAARPL
S473-ga RPLPRFNsVPLtDTG
T477-ga RFNsVPLtDTGHERQ
S533-p QEPQRADsPLEQPEG
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