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Protein Page:
M-CSF (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
M-CSF Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cytokine
Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; integral to membrane; plasma membrane; receptor complex
Molecular Function: protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding
Biological Process: positive regulation of monocyte differentiation; ossification; macrophage differentiation; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; reproductive developmental process; positive regulation of odontogenesis of dentine-containing teeth; osteoclast differentiation; positive regulation of multicellular organism growth; odontogenesis; cell proliferation; monocyte activation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; positive regulation of cell proliferation; innate immune response; hemopoiesis; positive regulation of Ras protein signal transduction; cell differentiation; positive regulation of cell-matrix adhesion; regulation of ossification; inflammatory response; positive regulation of macrophage differentiation; positive regulation of cell migration
Reference #:  P09603 (UniProtKB)
Alt. Names/Synonyms: colony stimulating factor 1 (macrophage); CSF-1; CSF1; Lanimostim; M-CSF; macrophage colony stimulating factor; Macrophage colony-stimulating factor 1; MCSF; MGC31930; Processed macrophage colony-stimulating factor 1
Gene Symbols: CSF1
Molecular weight: 60,179 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Select Structure to View Below

M-CSF

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S30 VCLLASRSITEEVSE
0 1 S256-ga AKQRPPRstCQSFEP
0 1 T257-ga KQRPPRstCQSFEPP
0 1 T266-ga QSFEPPEtPVVKDST
0 1 T363-ga GQQPADVtGtALPRV
0 1 T365-ga QPADVtGtALPRVGP
0 1 T376-ga RVGPVRPtGQDWNHt
0 1 T383-ga tGQDWNHtPQKtDHP
0 1 T387-ga WNHtPQKtDHPsALL
0 1 S391-ga PQKtDHPsALLRDPP
0 1 S428-ga AQPQLSRsHssGsVL
0 1 S430-ga PQLSRsHssGsVLPL
0 1 S431-ga QLSRsHssGsVLPLG
0 1 S433-ga SRsHssGsVLPLGEL
0 1 S451-ga RSTRDRRsPAEPEGG
0 1 S461-ga EPEGGPAsEGAARPL
0 1 S473-ga RPLPRFNsVPLtDTG
0 1 T477-ga RFNsVPLtDTGHERQ
0 1 S533-p QEPQRADsPLEQPEG
  mouse

 
S30-p VCLLMSRsIAKEVSE
S256 AKQRPPRSTCQTLES
T257 KQRPPRSTCQTLEST
Q266 QTLESTEQPNHGDRL
T360 DQKPVDITDRPLTEV
R362 KPVDITDRPLTEVNP
I373 EVNPMRPIGQTQNNT
T380 IGQTQNNTPEKTDGT
T384 QNNTPEKTDGTSTLR
S388 PEKTDGTSTLREDHQ
S425 AQLLLPKSHSWGIVL
S427 LLLPKSHSWGIVLPL
W428 LLPKSHSWGIVLPLG
I430 PKSHSWGIVLPLGEL
S448 RSTRDRRSPAELEGG
S458 ELEGGSASEGAARPV
S470 RPVARFNSIPLTDTG
T474 RFNSIPLTDTGHVEQ
S530 RDPQTLDSSVGRPED
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