Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
M-CSF (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
M-CSF Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cytokine
Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; integral to membrane; plasma membrane; receptor complex
Molecular Function: protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding
Biological Process: positive regulation of monocyte differentiation; macrophage differentiation; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; positive regulation of multicellular organism growth; osteoclast differentiation; odontogenesis; monocyte activation; positive regulation of cell proliferation; hemopoiesis; cell differentiation; positive regulation of macrophage differentiation; inflammatory response; positive regulation of cell-matrix adhesion; ossification; positive regulation of odontogenesis of dentine-containing teeth; reproductive developmental process; cell proliferation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; innate immune response; positive regulation of Ras protein signal transduction; regulation of ossification; positive regulation of cell migration
Reference #:  P09603 (UniProtKB)
Alt. Names/Synonyms: colony stimulating factor 1 (macrophage); CSF-1; CSF1; Lanimostim; M-CSF; macrophage colony stimulating factor; Macrophage colony-stimulating factor 1; MCSF; MGC31930; Processed macrophage colony-stimulating factor 1
Gene Symbols: CSF1
Molecular weight: 60,179 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Select Structure to View Below

M-CSF

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S30 VCLLASRSITEEVSE
0 1 Q181 SFAECSSQDVVTKPD
0 1 S256-ga AKQRPPRstCQSFEP
0 1 T257-ga KQRPPRstCQSFEPP
0 1 T266-ga QSFEPPEtPVVKDST
0 1 S345-p ARPSNFLsASsPLPA
0 1 S348-p SNFLsASsPLPAsAK
0 1 S353-p ASsPLPAsAKGQQPA
0 1 T363-ga GQQPADVtGtALPRV
0 1 T365-ga QPADVtGtALPRVGP
0 1 T376-ga RVGPVRPtGQDWNHt
0 1 T383-ga tGQDWNHtPQKtDHP
0 1 T387-ga WNHtPQKtDHPsALL
0 1 S391-ga PQKtDHPsALLRDPP
0 1 S420-p LSNPSTLsAQPQLsR
0 1 S426-p LsAQPQLsRsHssGs
0 1 S428-ga AQPQLsRsHssGsVL
0 1 S430-ga PQLsRsHssGsVLPL
0 1 S431-ga QLsRsHssGsVLPLG
0 1 S433-ga sRsHssGsVLPLGEL
0 1 S451-ga RSTRDRRsPAEPEGG
0 1 S461-ga EPEGGPAsEGAARPL
0 1 S473-ga RPLPRFNsVPLtDTG
0 1 T477-ga RFNsVPLtDTGHERQ
0 1 S533-p QEPQRADsPLEQPEG
  mouse

 
S30-p VCLLMSRsIAKEVSE
R181-m2 SFAKCSSrDVVTKPD
S256 AKQRPPRSTCQTLES
T257 KQRPPRSTCQTLEST
Q266 QTLESTEQPNHGDRL
S343 TDRPRALSASPFPKS
S345 RPRALSASPFPKSTE
S350 SASPFPKSTEDQKPV
T360 DQKPVDITDRPLTEV
R362 KPVDITDRPLTEVNP
I373 EVNPMRPIGQTQNNT
T380 IGQTQNNTPEKTDGT
T384 QNNTPEKTDGTSTLR
S388 PEKTDGTSTLREDHQ
V417 VSNSATPVAQLLLPK
P423 PVAQLLLPKSHSWGI
S425 AQLLLPKSHSWGIVL
S427 LLLPKSHSWGIVLPL
W428 LLPKSHSWGIVLPLG
I430 PKSHSWGIVLPLGEL
S448 RSTRDRRSPAELEGG
S458 ELEGGSASEGAARPV
S470 RPVARFNSIPLTDTG
T474 RFNSIPLTDTGHVEQ
S530 RDPQTLDSSVGRPED
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.